scholarly journals Amyloid-β positive individuals with subjective cognitive decline present increased CSF Neurofilament Light levels that relates to lower hippocampal volume

2021 ◽  
Author(s):  
Gonzalo Sánchez-Benavides ◽  
Marc Suárez-Calvet ◽  
Marta Milà-Alomà ◽  
Eider M. Arenaza-Urquijo ◽  
Oriol Grau-Rivera ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Amyloid Β ◽  
Hippocampal Volume ◽  
Subjective Cognitive Decline ◽  
Neurofilament Light ◽  
Light Levels

scholarly journals Amyloid‐positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to hippocampal volume

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Gonzalo Sánchez‐Benavides ◽  
Marc Suárez‐Calvet ◽  
Marta Milà‐Alomà ◽  
Eider M. Arenaza‐Urquijo ◽  
Oriol Grau‐Rivera ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Hippocampal Volume ◽  
Subjective Cognitive Decline ◽  
Neurofilament Light ◽  
Light Levels

scholarly journals Postoperative delirium is associated with increased plasma neurofilament light

Brain ◽  
2019 ◽  
Vol 143 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Cameron P Casey ◽  
Heidi Lindroth ◽  
Rosaleena Mohanty ◽  
Zahra Farahbakhsh ◽  
Tyler Ballweg ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Postoperative Delirium ◽  
Neuronal Injury ◽  
Dose Dependence ◽  
Hippocampal Volume ◽  
Mean Difference ◽  
Neurofilament Light ◽  
Light Levels ◽  
Potential Marker

Abstract While delirium is associated with cognitive decline and dementia, there is limited evidence to support causality for this relationship. Clarification of how delirium may cause cognitive decline, perhaps through evidence of contemporaneous neuronal injury, would enhance plausibility for a causal relationship. Dose-dependence of neuronal injury with delirium severity would further enhance the biological plausibility for this relationship. We tested whether delirium is associated with neuronal injury in 114 surgical patients recruited to a prospective biomarker cohort study. Patients underwent perioperative testing for changes in neurofilament light, a neuronal injury biomarker, as well as a panel of 10 cytokines, with contemporaneous assessment of delirium severity and incidence. A subset of patients underwent preoperative MRI. Initially we confirmed prior reports that neurofilament light levels correlated with markers of neurodegeneration [hippocampal volume (ΔR2 = 0.129, P = 0.015)] and white matter changes including fractional anisotropy of white matter (ΔR2 = 0.417, P < 0.001) with similar effects on mean, axial and radial diffusivity) in our cohort and that surgery was associated with increasing neurofilament light from preoperative levels [mean difference (95% confidence interval, CI) = 0.240 (0.178, 0.301) log10 (pg/ml), P < 0.001], suggesting putative neuronal injury. Next, we tested the relationship with delirium. Neurofilament light rose more sharply in participants with delirium compared to non-sufferers [mean difference (95% CI) = 0.251 (0.136, 0.367) log10 (pg/ml), P < 0.001]. This relationship showed dose-dependence, such that neurofilament light rose proportionately to delirium severity (ΔR2 = 0.199, P < 0.001). Given that inflammation is considered an important driver of postoperative delirium, next we tested whether neurofilament light, as a potential marker of neurotoxicity, may contribute to the pathogenesis of delirium independent of inflammation. From a panel of 10 cytokines, the pro-inflammatory cytokine IL-8 exhibited a strong correlation with delirium severity (ΔR2 = 0.208, P < 0.001). Therefore, we tested whether the change in neurofilament light contributed to delirium severity independent of IL-8. Neurofilament light was independently associated with delirium severity after adjusting for the change in inflammation (ΔR2 = 0.040, P = 0.038). These data suggest delirium is associated with exaggerated increases in neurofilament light and that this putative neurotoxicity may contribute to the pathogenesis of delirium itself, independent of changes in inflammation.

IC-P-138: High CSF TAU is Related to Reduced Hippocampal Volume and Subjective Cognitive Decline in Healthy Elderly With Amyloid Pathology

2016 ◽  
Vol 12 ◽  
pp. P102-P103
Author(s):  
Alexa Pichet Binette ◽  
Jacob W. Vogel ◽  
Vladimir S. Fonov ◽  
Cécile Madjar ◽  
Jennifer Tremblay-Mercier ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Hippocampal Volume ◽  
Subjective Cognitive Decline ◽  
Amyloid Pathology ◽  
Healthy Elderly

Associations Between the Subjective Cognitive Decline-Questionnaire’s Scores, Gray Matter Volume, and Amyloid-β Levels

2019 ◽  
Vol 72 (4) ◽  
pp. 1287-1302
Author(s):  
Natalia Valech ◽  
Gonzalo Sánchez-Benavides ◽  
Adrià Tort-Merino ◽  
Nina Coll-Padrós ◽  
Jaume Olives ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Matter Volume

scholarly journals Incidence of subjective cognitive decline is associated with amyloid‐β pathology, whereas stability relates to neurodegeneration

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Gonzalo Sánchez‐Benavides ◽  
Oriol Grau‐Rivera ◽  
Marc Suárez‐Calvet ◽  
Marta Milà‐Alomà ◽  
Aida Niñerola‐Baizán ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Amyloid Β ◽  
Subjective Cognitive Decline

The psychological impact of disclosing amyloid status to Japanese elderly: a preliminary study on asymptomatic patients with subjective cognitive decline

2017 ◽  
Vol 30 (5) ◽  
pp. 635-639 ◽  
Author(s):  
Taisei Wake ◽  
Hajime Tabuchi ◽  
Kei Funaki ◽  
Daisuke Ito ◽  
Bun Yamagata ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
State Anxiety ◽  
Empirical Studies ◽  
Amyloid Β ◽  
Anxiety And Depression ◽  
Subjective Cognitive Decline ◽  
Amyloid Pet ◽  
Asymptomatic Patients ◽  
Short Period ◽  
Significant Difference

ABSTRACTIn Japan, 4.6 million people are living with dementia and the number is expected to rise to 7 million by 2025. Amyloid-β (Aβ) positron emission tomography (PET) is used for cognitively normal Japanese people with or without subjective cognitive decline (SCD) for the purpose of clinical trials or diagnosis. Nevertheless, no empirical studies have been conducted on the safety of disclosing amyloid status to such populations. We conducted amyloid PET imaging on 42 participants (Aβ positive (n = 10) and negative (n = 32)). State anxiety and depression were measured at pre- and post-disclosure, and test-related distress at post-disclosure. Mean state anxiety and depression scores were below the cut-off through pre- and post-disclosure in the Aβ positive and negative groups. State anxiety and depression did not change over time and were not different between groups. Mean test-related distress scores were within normal limits at post-disclosure in both groups. No significant difference was found between groups. Disclosing Aβ positive results did not cause greater mood disturbance than negative results in a short period of time. The short-term psychological safety of disclosing Aβ PET results to asymptomatic Japanese adults with SCD was indicated.

scholarly journals Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load

2021 ◽  
Vol 13 ◽  
Author(s):  
Claudia Schwarz ◽  
Catharina Lange ◽  
Gloria S. Benson ◽  
Nora Horn ◽  
Katharina Wurdack ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Frontal Cortex ◽  
Parietal Cortex ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Older Individuals ◽  
Cognitive Complaints ◽  
Cerebral Amyloid ◽  
State Worry ◽  
Subjective Cognitive Complaints

Subjective cognitive decline (SCD) is considered an early risk stage for dementia due to Alzheimer's disease (AD) and the development of pathological brain changes, such as the aggregation of amyloid-beta (amyloid-β) plaques. This study evaluates the association between specific features of SCD and cerebral amyloid-β load measured by positron emission tomography (PET) with 18F-florbetaben in 40 cognitively normal older individuals. Global amyloid-β, as well as regional amyloid-β load for the frontal, temporal, parietal, and cingulate cortex, was quantified. Specific features of SCD, such as subjective cognitive complaints and worry, were assessed using the 39-item Everyday Cognition Scales and the 16-item Penn State Worry Questionnaire. Spearman's rank partial correlation analyses, adjusted for age and apolipoprotein E ε4 status, were conducted to test the associations between specific features of SCD and cerebral amyloid-β load. The severity of subjective cognitive complaints in everyday memory and organization was positively correlated with amyloid-β load in the frontal cortex. In addition, the severity of subjective cognitive complaints in everyday planning was positively correlated with amyloid-β load in the parietal cortex. Higher levels of worry were associated with higher amyloid-β load in the frontal cortex. After correction of the PET data for partial volume effects, these associations were reduced to trend level. In conclusion, the severity of subjective cognitive complaints and the level of trait worry were positively associated with cortical amyloid-β burden, particularly in the frontal and parietal cortex. Further studies are required to elucidate the direction of these associations in order to develop strategies to prevent amyloid deposition and cognitive decline.

scholarly journals Amyloid-β Imaging in Older Adults Presenting to a Memory Clinic with Subjective Cognitive Decline: A Pilot Study

2015 ◽  
Vol 48 (s1) ◽  
pp. S151-S159 ◽  
Author(s):  
Beth E. Snitz ◽  
Oscar L. Lopez ◽  
Eric McDade ◽  
James T. Becker ◽  
Ann D. Cohen ◽  
...  
Keyword(s):  
Older Adults ◽  
Pilot Study ◽  
Cognitive Decline ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Memory Clinic

scholarly journals Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment

2019 ◽  
Vol 75 (7) ◽  
pp. 1382-1392 ◽  
Author(s):  
Marie Caillaud ◽  
Carol Hudon ◽  
Benjamin Boller ◽  
Simona Brambati ◽  
Simon Duchesne ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Episodic Memory ◽  
Cognitive Decline ◽  
White Matter Hyperintensities ◽  
Hippocampal Volume ◽  
Subjective Cognitive Decline

Abstract Objective The concepts of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have been proposed to identify individuals in the early stages of Alzheimer’s disease (AD), or other neurodegenerative diseases. One approach to validate these concepts is to investigate the relationship between pathological brain markers and cognition in those individuals. Method We included 126 participants from the Consortium for the Early Identification of Alzheimer’s disease-Quebec (CIMA-Q) cohort (67 SCD, 29 MCI, and 30 cognitively healthy controls [CH]). All participants underwent a complete cognitive assessment and structural magnetic resonance imaging. Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs). Results Significant differences were found between participants with MCI and CH on episodic and executive tasks, but no differences were found when comparing SCD and CH. Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups. Discussion As expected, the SCD group was shown to be cognitively healthy on tasks where MCI participants showed impairment. However, SCD’s hippocampal volume related to episodic memory performances, and WMH to executive functions. Thus, SCD represents a valid research concept and should be used, alongside MCI, to better understand the preclinical/prodromal phase of AD.

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