T2 MRI texture analysis is a sensitive measure of tissue injury and recovery resulting from acute inflammatory lesions in multiple sclerosis

NeuroImage ◽  
2009 ◽  
Vol 47 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Yunyan Zhang ◽  
Hongmei Zhu ◽  
J.R. Mitchell ◽  
Fiona Costello ◽  
Luanne M. Metz
Keyword(s):  
Multiple Sclerosis ◽  
Texture Analysis ◽  
Tissue Injury ◽  
Inflammatory Lesions ◽  
Sensitive Measure ◽  
T2 Mri

Texture analysis differentiates persistent and transient T1 black holes at acute onset in multiple sclerosis: A preliminary study

2011 ◽  
Vol 17 (5) ◽  
pp. 532-540 ◽  
Author(s):  
Yunyan Zhang ◽  
Anthony Traboulsee ◽  
Yinshan Zhao ◽  
Luanne M Metz ◽  
David K Li
Keyword(s):  
Multiple Sclerosis ◽  
Black Holes ◽  
Texture Analysis ◽  
Tissue Damage ◽  
Tissue Injury ◽  
Lesion Size ◽  
Acute Onset ◽  
Coarse Texture ◽  
Preliminary Study ◽  
Stockwell Transform

Background and Objective: The persistence of new enhancing T1 hypointense lesions (acute black holes, ABHs) in multiple sclerosis (MS) cannot be predicted visually at lesion onset. Texture analysis using the polar Stockwell transform (PST) applied to conventional MR images however shows promise in quantifying tissue injury early. The objective of this study was to explore whether ABHs that persist (pABHs) differ from those that are transient (tABHs) using PST texture analysis. Methods: Fifteen ABHs (8 pABHs; 7 tABHs) from 9 patients were analyzed on 3T images obtained during a clinical trial. Persistence was defined as remaining T1 hypointense 5–8 months later. NAWM regions were examined to control for changes unrelated to ABHs. Results: At first appearance, there was higher coarse texture indicating greater tissue damage in the pABHs than in the tABHs ( p < 0.01). Both had greater coarse texture than the contralateral and general NAWM ( p ≤ 0.01). No difference was identified in normalized signal intensity between pABHs and tABHs and neither demonstrated location preference. While tABHs tended to be smaller than pABHs there was no correlation between lesion size and texture (r = 0.44, p > 0.05). Furthermore, coarse texture content appeared to predict persistence of individual lesions. Conclusions: This preliminary study suggests that PST texture could predict persistence of tissue injury based on the severity of structural disorganization within acute lesions. While confirmation of this data is required texture analysis may prove to be a valuable tool to quantify tissue damage and predict recovery in proof-of-concept neuroprotection and repair trials.

scholarly journals Serum levels of brain-derived neurotrophicfactor correlate with the number of T2 MRI lesions in multiple sclerosis

2012 ◽  
Vol 45 (1) ◽  
pp. 68-71 ◽  
Author(s):  
E.R. Comini-Frota ◽  
D.H. Rodrigues ◽  
E.C. Miranda ◽  
D.G. Brum ◽  
D.R. Kaimen-Maciel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Serum Levels ◽  
T2 Mri

scholarly journals Application of Texture Analysis in Diagnosis of Multiple Sclerosis by Magnetic Resonance Imaging

2015 ◽  
Vol 7 (6) ◽  
Author(s):  
Ali Abbasian Ardakani ◽  
Akbar Gharbali ◽  
Yalda Saniei ◽  
Arash Mosarrezaii ◽  
Surena Nazarbaghi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Texture Analysis ◽  
Resonance Imaging

scholarly journals MRI Texture Analysis in Multiple Sclerosis

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yunyan Zhang
Keyword(s):  
Multiple Sclerosis ◽  
Texture Analysis ◽  
Disease Pathogenesis ◽  
Accurate Identification ◽  
Future Directions ◽  
Structural Alterations ◽  
Tissue Integrity ◽  
If Technique ◽  
Organizational Patterns ◽  
Generate Characteristic

Multiple sclerosis (MS) is a complicated disease characterized by heterogeneous pathology that varies across individuals. Accurate identification and quantification of pathological changes may facilitate a better understanding of disease pathogenesis and progression and help identify novel therapies for MS patients. Texture analysis evaluates interpixel relationships that generate characteristic organizational patterns in an image, many of which are beyond the ability of visual perception. Given its promise detecting subtle structural alterations texture analysis may be an attractive means to evaluate disease activity and evolution. It may also become a new tool to assess therapeutic efficacy if technique issues are resolved and pathological correlates are further confirmed. This paper describes the concept, strategies, and considerations of MRI texture analysis; summarizes applications of texture analysis in MS as a measure of tissue integrity and its clinical relevance; then discusses potentially future directions of texture analysis in MS.

scholarly journals Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Genaro G. Ortiz ◽  
Fermín P. Pacheco-Moisés ◽  
Oscar K. Bitzer-Quintero ◽  
Ana C. Ramírez-Anguiano ◽  
Luis J. Flores-Alvarado ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Tissue Injury ◽  
Autoimmune Disorder ◽  
Demyelinating Lesions ◽  
The Central Nervous System ◽  
The Brain ◽  
And Oxidative Stress

Multiple sclerosis (MS) exhibits many of the hallmarks of an inflammatory autoimmune disorder including breakdown of the blood-brain barrier (BBB), the recruitment of lymphocytes, microglia, and macrophages to lesion sites, the presence of multiple lesions, generally being more pronounced in the brain stem and spinal cord, the predominantly perivascular location of lesions, the temporal maturation of lesions from inflammation through demyelination, to gliosis and partial remyelination, and the presence of immunoglobulin in the central nervous system and cerebrospinal fluid. Lymphocytes activated in the periphery infiltrate the central nervous system to trigger a local immune response that ultimately damages myelin and axons. Pro-inflammatory cytokines amplify the inflammatory cascade by compromising the BBB, recruiting immune cells from the periphery, and activating resident microglia. inflammation-associated oxidative burst in activated microglia and macrophages plays an important role in the demyelination and free radical-mediated tissue injury in the pathogenesis of MS. The inflammatory environment in demyelinating lesions leads to the generation of oxygen- and nitrogen-free radicals as well as proinflammatory cytokines which contribute to the development and progression of the disease. Inflammation can lead to oxidative stress and vice versa. Thus, oxidative stress and inflammation are involved in a self-perpetuating cycle.

Sign in / Sign up

Export Citation Format

Share Document