Food restriction increases NMDA receptor-mediated calcium—calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic amp response element-binding protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor stimulation in rats

Neuroscience ◽  
2005 ◽  
Vol 132 (4) ◽  
pp. 1035-1043 ◽  
Author(s):  
S.L. Haberny ◽  
K.D. Carr
Keyword(s):  
Nucleus Accumbens ◽  
Nmda Receptor ◽  
Cyclic Amp ◽  
Food Restriction ◽  
Receptor Stimulation ◽  
Extracellular Signal Regulated Kinase ◽  
Calmodulin Kinase ◽  
Extracellular Signal ◽  
Element Binding Protein ◽  
Cyclic Amp Response Element

scholarly journals Role of convergent activation of glutamatergic and dopaminergic systems in the nucleus accumbens in the development of methamphetamine psychosis and dependence

2013 ◽  
Vol 16 (6) ◽  
pp. 1341-1350 ◽  
Author(s):  
Masayuki Miyazaki ◽  
Yukihiro Noda ◽  
Akihiro Mouri ◽  
Kazuto Kobayashi ◽  
Masayoshi Mishina ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Intracellular Signalling ◽  
Signalling Pathways ◽  
Repeated Treatment ◽  
Glutamatergic Transmission ◽  
Intracellular Signalling Pathways ◽  
Calmodulin Kinase ◽  
Dopaminergic Systems ◽  
Element Binding Protein ◽  
Cyclic Amp Response Element

Abstract Methamphetamine (Meth) abuse can result in long-lasting psychosis and dependence. The nucleus accumbens (NAc), which controls psychomotor and reward behaviours, is an important interface between the limbic system and receives convergent projections from dopaminergic and glutamatergic terminals. This study investigated the involvements of dopaminergic and glutamatergic transmission in the development of Meth psychosis and dependence by using tyrosine hydroxylase heterozygous mutant (TH+/−) mice and N-methyl-d-aspartate receptor knockout (NR2A−/−) mice. Repeated treatment with Meth (1 mg/kg s.c.) for 7 d in wild-type mice led to the development of behavioural abnormalities such as hyperactivity, sensory motor gating deficits and place preference. Associated with the behavioural changes, repeated treatment with Meth led to protein kinase A activation and phosphorylation of Ca2+/calmodulin kinase II and cyclic AMP response element binding protein in the NAc. In contrast, TH+/− and NR2A−/− mice displayed neither behavioural abnormalities nor activation of intracellular signalling pathways in the NAc. These results suggest that both dopaminergic and glutamatergic transmission play a crucial role in the development of Meth psychosis and dependence, which are associated with convergent activation of intracellular signalling pathways in the NAc.

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