Estrogen-related receptor alpha (ERRα) is required for PGC-1α-dependent gene expression in the mouse brain

Neuroscience ◽  
2021 ◽  
Author(s):  
L.J. McMeekin ◽  
K.L. Joyce ◽  
L.M. Jenkins ◽  
B.M. Bohannon ◽  
K.D. Patel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Brain ◽  
Receptor Alpha ◽  
Estrogen Related Receptor

scholarly journals Interplay between estrogen-related receptor alpha (ERRα) and gamma (ERRγ) on the regulation of ERRα gene expression

2007 ◽  
Vol 264 (1-2) ◽  
pp. 128-141 ◽  
Author(s):  
Zhiping Zhang ◽  
Christina T. Teng
Keyword(s):  
Gene Expression ◽  
Receptor Alpha ◽  
Estrogen Related Receptor

719-P: Inducible Estrogen-Related Receptor Alpha Overexpression Stimulates Skeletal Muscle Oxidative Metabolism and Improves Exercise Endurance in Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 719-P
Author(s):  
JING LI ◽  
ANGELICA HAMILTON ◽  
JANICE M. HUSS
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Metabolism ◽  
Receptor Alpha ◽  
Exercise Endurance ◽  
Estrogen Related Receptor

The Role of Estrogen-Related Receptor Alpha in Steroidogenesis in the Breast

2009 ◽  
Author(s):  
Linda Grasfeder
Keyword(s):  
Receptor Alpha ◽  
Estrogen Related Receptor

scholarly journals Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Yuen Gao ◽  
Natalia Duque-Wilckens ◽  
Mohammad B. Aljazi ◽  
Yan Wu ◽  
Adam J. Moeser ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Brain ◽  
Molecular Mechanisms ◽  
Gene Mutations ◽  
Autism Spectrum ◽  
Normal Brain ◽  
Critical Function ◽  
Developmental Defects ◽  
Neurodevelopmental Disease ◽  
Developing Mouse Brain

AbstractAutism spectrum disorder (ASD) is a neurodevelopmental disease associated with various gene mutations. Recent genetic and clinical studies report that mutations of the epigenetic gene ASH1L are highly associated with human ASD and intellectual disability (ID). However, the causality and underlying molecular mechanisms linking ASH1L mutations to genesis of ASD/ID remain undetermined. Here we show loss of ASH1L in the developing mouse brain is sufficient to cause multiple developmental defects, core autistic-like behaviors, and impaired cognitive memory. Gene expression analyses uncover critical roles of ASH1L in regulating gene expression during neural cell development. Thus, our study establishes an ASD/ID mouse model revealing the critical function of an epigenetic factor ASH1L in normal brain development, a causality between Ash1L mutations and ASD/ID-like behaviors in mice, and potential molecular mechanisms linking Ash1L mutations to brain functional abnormalities.

Aphid estrogen-related receptor controls glycolytic gene expression and fecundity

2021 ◽  
Vol 130 ◽  
pp. 103529
Author(s):  
Woo-Ram Park ◽  
Da Jung Lim ◽  
Hyunkyu Sang ◽  
Eunae Kim ◽  
Jae-Hak Moon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Glycolytic Gene ◽  
Estrogen Related Receptor

scholarly journals Uncovering Statistical Links Between Gene Expression and Structural Connectivity Patterns in the Mouse Brain

2021 ◽  
Author(s):  
Nestor Timonidis ◽  
Alberto Llera ◽  
Paul H. E. Tiesinga
Keyword(s):  
Gene Expression ◽  
Mouse Brain ◽  
Structural Connectivity ◽  
Enrichment Analysis ◽  
Underlying Mechanism ◽  
Synaptic Function ◽  
Reticular Nucleus ◽  
Sources Of Information ◽  
Independent Components ◽  
Brain Connectome

AbstractFinding links between genes and structural connectivity is of the utmost importance for unravelling the underlying mechanism of the brain connectome. In this study we identify links between the gene expression and the axonal projection density in the mouse brain, by applying a modified version of the Linked ICA method to volumetric data from the Allen Institute for Brain Science for identifying independent sources of information that link both modalities at the voxel level. We performed separate analyses on sets of projections from the visual cortex, the caudoputamen and the midbrain reticular nucleus, and we determined those brain areas, injections and genes that were most involved in independent components that link both gene expression and projection density data, while we validated their biological context through enrichment analysis. We identified representative and literature-validated cortico-midbrain and cortico-striatal projections, whose gene subsets were enriched with annotations for neuronal and synaptic function and related developmental and metabolic processes. The results were highly reproducible when including all available projections, as well as consistent with factorisations obtained using the Dictionary Learning and Sparse Coding technique. Hence, Linked ICA yielded reproducible independent components that were preserved under increasing data variance. Taken together, we have developed and validated a novel paradigm for linking gene expression and structural projection patterns in the mouse mesoconnectome, which can power future studies aiming to relate genes to brain function.

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