719-P: Inducible Estrogen-Related Receptor Alpha Overexpression Stimulates Skeletal Muscle Oxidative Metabolism and Improves Exercise Endurance in Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 719-P
Author(s):  
JING LI ◽  
ANGELICA HAMILTON ◽  
JANICE M. HUSS
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Metabolism ◽  
Receptor Alpha ◽  
Exercise Endurance ◽  
Estrogen Related Receptor

scholarly journals The Corepressor NCoR1 Antagonizes PGC-1  and Estrogen-Related Receptor   in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

2012 ◽  
Vol 32 (24) ◽  
pp. 4913-4924 ◽  
Author(s):  
J. Perez-Schindler ◽  
S. Summermatter ◽  
S. Salatino ◽  
F. Zorzato ◽  
M. Beer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Metabolism ◽  
Muscle Function ◽  
Skeletal Muscle Function ◽  
Estrogen Related Receptor

METABOLIC RESPONSE TO MALE HORMONE AND THYROID ACTIVITY IN THE INDIAN GARDEN LIZARD, CALOTES VERSICOLOR

1974 ◽  
Vol 61 (2) ◽  
pp. 285-291 ◽  
Author(s):  
ASHA CHANDOLA ◽  
D. SURESH KUMAR ◽  
J. P. THAPLIYAL
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Metabolism ◽  
Environmental Temperature ◽  
Metabolic Response ◽  
Tissue Oxygen ◽  
Thyroid Activity ◽  
Physiological Importance ◽  
Calotes Versicolor ◽  
Isolated Liver ◽  
Male Hormone

SUMMARY Thyroidectomy and orchidectomy led to significant reduction in the oxidative metabolism of isolated liver and skeletal muscle tissue (at 30 °C) in Calotes versicolor. Thyroxine and male hormone were shown to increase this parameter in intact and orchidectomized lizards respectively. The effects of thyroidectomy and orchidectomy on tissue oxygen uptake were not additive. It is supposed that by its effect on oxidative metabolism male hormone may be of a greater physiological importance for reptiles than for other vertebrates. The present results show also that changes in environmental temperature can counteract the depressive effect of orchidectomy on the thyroid of this species of lizard.

scholarly journals The Transcriptional Corepressor RIP140 Regulates Oxidative Metabolism in Skeletal Muscle

2007 ◽  
Vol 6 (3) ◽  
pp. 236-245 ◽  
Author(s):  
Asha Seth ◽  
Jennifer H. Steel ◽  
Donna Nichol ◽  
Victoria Pocock ◽  
Mande K. Kumaran ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Metabolism ◽  
Transcriptional Corepressor

HIF-1α in endurance training: suppression of oxidative metabolism

2007 ◽  
Vol 293 (5) ◽  
pp. R2059-R2069 ◽  
Author(s):  
Steven D. Mason ◽  
Helene Rundqvist ◽  
Ioanna Papandreou ◽  
Roger Duh ◽  
Wayne J. McNulty ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Endurance Training ◽  
Oxidative Metabolism ◽  
Hypoxia Inducible Factor ◽  
Transcriptional Response ◽  
Oxidative Capacity ◽  
Pyruvate Dehydrogenase Kinase ◽  
Amp Activated Protein Kinase ◽  
Training Protocol

During endurance training, exercising skeletal muscle experiences severe and repetitive oxygen stress. The primary transcriptional response factor for acclimation to hypoxic stress is hypoxia-inducible factor-1α (HIF-1α), which upregulates glycolysis and angiogenesis in response to low levels of tissue oxygenation. To examine the role of HIF-1α in endurance training, we have created mice specifically lacking skeletal muscle HIF-1α and subjected them to an endurance training protocol. We found that only wild-type mice improve their oxidative capacity, as measured by the respiratory exchange ratio; surprisingly, we found that HIF-1α null mice have already upregulated this parameter without training. Furthermore, untrained HIF-1α null mice have an increased capillary to fiber ratio and elevated oxidative enzyme activities. These changes correlate with constitutively activated AMP-activated protein kinase in the HIF-1α null muscles. Additionally, HIF-1α null muscles have decreased expression of pyruvate dehydrogenase kinase I, a HIF-1α target that inhibits oxidative metabolism. These data demonstrate that removal of HIF-1α causes an adaptive response in skeletal muscle akin to endurance training and provides evidence for the suppression of mitochondrial biogenesis by HIF-1α in normal tissue.

scholarly journals Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Allan Tran ◽  
Charlotte Scholtes ◽  
Mario Songane ◽  
Claudia Champagne ◽  
Luc Galarneau ◽  
...  
Keyword(s):  
Transcriptional Control ◽  
Current Knowledge ◽  
Experimental Colitis ◽  
Protective Effects ◽  
Mitochondrial Energy Metabolism ◽  
Receptor Alpha ◽  
Cell Counts ◽  
Α Diversity ◽  
Estrogen Related Receptor

AbstractThe estrogen-related receptor alpha (ERRα) is a primary regulator of mitochondrial energy metabolism, function and dynamics, and has been implicated in autophagy and immune regulation. ERRα is abundantly expressed in the intestine and in cells of the immune system. However, its role in inflammatory bowel disease (IBD) remains unknown. Here, we report a protective role of ERRα in the intestine. We found that mice deficient in ERRα were susceptible to experimental colitis, exhibiting increased colon inflammation and tissue damage. This phenotype was mediated by impaired compensatory proliferation of intestinal epithelial cells (IEC) following injury, enhanced IEC apoptosis and necrosis and reduced mucus-producing goblet cell counts. Longitudinal analysis of the microbiota demonstrated that loss of ERRα lead to a reduction in microbiome α-diversity and depletion of healthy gut bacterial constituents. Mechanistically, ERRα mediated its protective effects by acting within the radio-resistant compartment of the intestine. It promoted disease tolerance through transcriptional control of key genes involved in intestinal tissue homeostasis and repair. These findings provide new insights on the role of ERRα in the gut and extends our current knowledge of nuclear receptors implicated in IBD.

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