Radiation-induced cross-linking of polyvinylpyrrolidone-poly(acrylic acid) complexes

2005 ◽  
Vol 236 (1-4) ◽  
pp. 391-398 ◽  
Author(s):  
Artur Henke ◽  
Slawomir Kadlubowski ◽  
Piotr Ulanski ◽  
Janusz M. Rosiak ◽  
Karl-Friedrich Arndt
Keyword(s):  
Acrylic Acid ◽  
Cross Linking ◽  
Radiation Induced ◽  
Poly Acrylic Acid

scholarly journals Development and Characterization of Cross-Linked Poly(acrylic acid) Hydrogel Containing Drug by Radiation-Based Techniques

2018 ◽  
Author(s):  
Jin-Oh Jeong ◽  
Jae Baik ◽  
Sung-Jun An ◽  
Sung-In Jeong ◽  
Jae-Young Lee ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Cross Linking ◽  
Radiation Doses ◽  
Swelling Ratio ◽  
Chemical Additives ◽  
Drug Delivery Carrier ◽  
Radiation Induced ◽  
Crystalline Nature ◽  
Poly Acrylic Acid

Poly(acrylic acid) (PAAc) hydrogels possess good bioadhesive properties and allow enhanced penetration of drugs. In addition, it is possible to localize the absorption site of the drug in the hydrogel and increase the drug residence time. As opposed to other cross-linking processes radiation-induced polymer cross-linking can be easily and rapidly carried out without the use of cross-linking agents and other chemical additives. In this study, we fabricated metronidazole (MD) containing PAAc hydrogel (MD/PAAc) with different MD contents (0.1, 0.25, 0.5 wt%) using varying radiation doses (25, 50, 75 kGy) by gamma-irradiation. The physical and thermal properties were determined by gel content analysis, swelling ratio measurements, compressive strength measurements, differential scanning calorimetery, and thermogravimetric analysis. The properties of the hydrogel degraded due to the crystalline nature of MD. The properties of the hydrogel degraded due to the crystalline nature of MD. Cumulative release observed after 50 min in the case of 0.5MD/PAAc and 0.1MD/PAAc was 50% and 10%, respectively. Our findings suggest that MD/PAAc could be a suitable drug delivery carrier for use with radiation-based techniques.

Pulses of Fast Electrons as a Tool To Synthesize Poly(acrylic acid) Nanogels. Intramolecular Cross-Linking of Linear Polymer Chains in Additive-Free Aqueous Solution

2003 ◽  
Vol 36 (7) ◽  
pp. 2484-2492 ◽  
Author(s):  
Slawomir Kadlubowski ◽  
Jaroslaw Grobelny ◽  
Wielislaw Olejniczak ◽  
Michal Cichomski ◽  
Piotr Ulanski
Keyword(s):  
Aqueous Solution ◽  
Acrylic Acid ◽  
Polymer Chains ◽  
Linear Polymer ◽  
Cross Linking ◽  
Fast Electrons ◽  
Poly Acrylic Acid

Radiation-induced synthesis of poly(acrylic acid) nanogels

2018 ◽  
Vol 142 ◽  
pp. 125-129 ◽  
Author(s):  
Malgorzata Matusiak ◽  
Slawomir Kadlubowski ◽  
Piotr Ulanski
Keyword(s):  
Acrylic Acid ◽  
Radiation Induced ◽  
Poly Acrylic Acid

scholarly journals Radiation synthesis of poly(acrylic acid) nanogels for drug delivery applications – post-synthesis product colloidal stability

Nukleonika ◽  
2021 ◽  
Vol 66 (4) ◽  
pp. 179-186
Author(s):  
Beata P. Rurarz ◽  
Natalia Gibka ◽  
Małgorzata Bukowczyk ◽  
Sławomir Kadłubowski ◽  
Piotr Ulański
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Colloidal Stability ◽  
Biologically Active ◽  
Cross Linking ◽  
Synthesis Product ◽  
High Dose ◽  
Water Radiolysis ◽  
Drug Delivery Applications ◽  
Poly Acrylic Acid

Abstract Synthesis of polymer nanogels (NGs) for biomedical applications is considered to be a very promising application in radiation engineering. Under high-dose pulse irradiation of dilute aqueous polymer solution, reactive species generated by water radiolysis can create multiple radicals on each macromolecule and consequently induce intramolecular cross-linking of polymer chains, resulting in NG formation. The obtained products are free from harmful monomers, initiators, and cross-linking agents, which makes them potentially applicable for drug delivery applications. One of the biggest challenges in handling and use of nanoparticles, however, is the colloidal stability, when aqueous suspensions are stored for prolonged periods. Therefore, development of the best protocols for the particular nanocarrier storage is key. To address this need, we have performed the prospective study in which we systematically assessed the influence of various processing and storage scenarios feasible in our lab, on the colloidal stability of the radiation-synthesized poly(acrylic acid) (PAA) NG particles in suspension. This allowed us to choose the optimal way of handling the product after its synthesis. We confirmed that none of the strategies we used and tested are substantially detrimental to our product. Filtration with 0.2-μm filters was proven sufficient for sample purification and prolonged storage in aqueous suspension did not exert a negative effect on the colloidal stability of particles suspension. We have also demonstrated that lyoprotectant-free lyophilization was suitable for our polymer nanoparticles. This is an important fact for further application of particles as nanocarriers for biologically active compounds such as targeting ligands or therapeutic moieties.

Radiation Induced Generation of Core–Shell Nanoparticles in Polyelectrolyte Films of Poly(acrylic acid)–Poly(ethylenimine) Complex with Copper and Silver Ions

2020 ◽  
Vol 124 (26) ◽  
pp. 14409-14418
Author(s):  
Dmitry I. Klimov ◽  
Elena A. Zezina ◽  
Yan V. Zubavichus ◽  
Sergey B. Zezin ◽  
Sergey N. Chvalun ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Silver Ions ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Radiation Induced ◽  
Core Shell Nanoparticles ◽  
Poly Acrylic Acid

pH Effects on the Complexation, Miscibility and Radiation-Induced Crosslinking in Poly(acrylic acid)-Poly(vinyl alcohol) Blends

2005 ◽  
Vol 5 (5) ◽  
pp. 424-432 ◽  
Author(s):  
Zauresh S. Nurkeeva ◽  
Grigoriy A. Mun ◽  
Artem V. Dubolazov ◽  
Vitaliy V. Khutoryanskiy
Keyword(s):  
Acrylic Acid ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Ph Effects ◽  
Radiation Induced ◽  
Poly Acrylic Acid
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