Activity of nitric oxide synthase isoforms in acute brain oxidative damage induced by ozone exposure

Nitric Oxide ◽  
2018 ◽  
Vol 75 ◽  
pp. 42-52 ◽  
Author(s):  
Juan Carlos Martínez-Lazcano ◽  
Edith González-Guevara ◽  
Verónica Custodio ◽  
Francisca Pérez-Severiano ◽  
Karen Olvera-Pérez ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxidative Damage ◽  
Ozone Exposure ◽  
Oxide Synthase

scholarly journals Nitric oxide synthase-mediated early nitric oxide burst alleviates water stress-induced oxidative damage in ammonium-supplied rice roots

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaochuang Cao ◽  
Chunquan Zhu ◽  
Chu Zhong ◽  
Junhua Zhang ◽  
Lianghuan Wu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Water Stress ◽  
Nitric Oxide Synthase ◽  
Oxidative Damage ◽  
Rice Roots ◽  
Oxide Synthase

Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase

2010 ◽  
Vol 58 (2) ◽  
pp. 105-112 ◽  
Author(s):  
Meital Portugal-Cohen ◽  
Ran Numa ◽  
Rami Yaka ◽  
Ron Kohen
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxidative Damage ◽  
Xanthine Oxidase ◽  
Oxide Synthase

Selective protection against oxidative damage in brain of mice with a targeted disruption of the neuronal nitric oxide synthase gene

2007 ◽  
Vol 85 (7) ◽  
pp. 1391-1402 ◽  
Author(s):  
Juan Carlos Martínez-Lazcano ◽  
Francisca Pérez-Severiano ◽  
Bruno Escalante ◽  
Joel Ramírez-Emiliano ◽  
Paula Vergara ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxidative Damage ◽  
Neuronal Nitric Oxide Synthase ◽  
Targeted Disruption ◽  
Selective Protection ◽  
Oxide Synthase

scholarly journals Nitric oxide synthase-mediated early nitric oxide-burst alleviates drought-induced oxidative damage in ammonium supplied-rice roots

2018 ◽  
Author(s):  
Cao Xiaochuang ◽  
Zhu Chunquan ◽  
Zhong Chu ◽  
Zhang Junhua ◽  
Zhu Lianfeng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxidative Damage ◽  
Protective Role ◽  
Antioxidant Defenses ◽  
No Production ◽  
No Donor ◽  
Rice Roots ◽  
Nos Inhibitor ◽  
Oxide Synthase

AbstractAmmonium (NH4+) can enhance rice drought tolerance in comparison to nitrate (NO3-). The mechanism underpinning this relationship was investigated based on the time-dependent nitric oxide (NO) production and its protective role in oxidative stress of NH4+-/NO3--supplied rice under drought. An early burst of NO was induced by drought 3h after root NH4+ treatment but not after NO3- treatment. Root oxidative damage induced by drought was significantly higher in NO3- than in NH4+-treatment due to its reactive oxygen species accumulation. Inducing NO production by applying NO donor 3h after NO3- treatment alleviated the oxidative damage, while inhibiting the early NO burst increased root oxidative damage in NH4+ treatment. Application of nitric oxide synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) completely suppressed NO synthesis in roots 3h after NH4+ treatment and aggravated drought-induced oxidative damage, indicating the aggravation of oxidative damage might have resulted from changes in NOS-mediated early NO burst. Drought also increased root antioxidant enzymes activities, which were further induced by NO donor but repressed by NO scavenger and NOS inhibitor in NH4+-treated roots. Thus, the NOS-mediated early NO burst plays an important role in alleviating oxidative damage induced by drought by enhancing antioxidant defenses in NH4+-supplied rice roots.HighlightNOS-mediated early NO burst plays an important role in alleviating oxidative damage induced by water stress, by enhancing the antioxidant defenses in roots supplemented with NH4+

scholarly journals Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats

2019 ◽  
Vol 20 (10) ◽  
pp. 2441 ◽  
Author(s):  
Valeria Sorrenti ◽  
Marco Raffaele ◽  
Luca Vanella ◽  
Rosaria Acquaviva ◽  
Loredana Salerno ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxidative Damage ◽  
Caffeic Acid ◽  
Heme Oxygenase ◽  
Diabetic Rats ◽  
Heme Oxygenase 1 ◽  
Protective Effects ◽  
Oxide Synthase

Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease resulting in the destruction of insulin producing β-cells of the pancreas, with consequent insulin deficiency and excessive glucose production. Hyperglycemia results in increased levels of reactive oxygen species (ROS) and nitrogen species (RNS) with consequent oxidative/nitrosative stress and tissue damage. Oxidative damage of the pancreatic tissue may contribute to endothelial dysfunction associated with diabetes. The aim of the present study was to investigate if the potentially protective effects of phenethyl ester of caffeic acid (CAPE), a natural phenolic compound occurring in a variety of plants and derived from honeybee hive propolis, and of a novel CAPE analogue, as heme oxygenase-1 (HO-1) inducers, could reduce pancreatic oxidative damage induced by excessive amount of glucose, affecting the nitric oxide synthase/dimethylarginine dimethylaminohydrolase (NOS/DDAH) pathway in streptozotocin-induced type 1 diabetic rats. Our data demonstrated that inducible nitric oxide synthase/gamma-Glutamyl-cysteine ligase (iNOS/GGCL) and DDAH dysregulation may play a key role in high glucose mediated oxidative stress, whereas HO-1 inducers such as CAPE or its more potent derivatives may be useful in diabetes and other stress-induced pathological conditions.

scholarly journals Oxidative damage and nitric oxide synthase induction by surgical uteroplacental circulation restriction in the rabbit fetal heart

2017 ◽  
Vol 37 (5) ◽  
pp. 453-459 ◽  
Author(s):  
Horacio Figueroa ◽  
Cristobal Alvarado ◽  
Jorge Cifuentes ◽  
Mauricio Lozano ◽  
Jocelyn Rocco ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxidative Damage ◽  
Fetal Heart ◽  
Oxide Synthase
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