Sensitized by a sea slug: site-specific short-term and general long-term sensitization in Aplysia following Navanax attack

2021 ◽  
pp. 107542
Author(s):  
Chrissy Pepino ◽  
Cyril Rakovski ◽  
Candace Gutierrez ◽  
Amanda Rodriguez ◽  
Scott Tillett ◽  
...  
Keyword(s):  
Author(s):  
Partha Chakrabarti ◽  
Sanjay Joshi ◽  
Kaushik Bose ◽  
Majid Al-Sharif

Normal procedure for design of a ship shaped Floating Production Unit (FPU) is to use Rule Based approach recommended by the Classification Societies. In this approach the primary design strength quantities such as longitudinal and transverse wave induced bending moments, shear forces etc. are calculated based on formulae prescribed by the Classification Society Rules. In the Rules, these formulae have been validated for a class of ocean going vessels such as container ships or tankers, as the case may be, for open ocean conditions akin to the Northern Atlantic. Thus, actual hydrodynamic response of the vessel to a defined sea conditions at a location of service need not be calculated. FPUs are different from ocean going vessels in that they are usually fixed at a location for several years of service with the help of some station keeping arrangement such as a mooring system or a dynamic positioning system, except for transit. An alternate approach is to use direct calculations for hydrodynamic response of the vessel to the site specific sea conditions at the operating site. The hull geometry may also be very much different from a conventional tanker due to addition of sponsons that could justify such an approach. In addition, an FPU is likely to support several equipment modules on top of the deck which is different from the loading of usual cargo ships and may demand more accurate calculations. Thus, in order to design the module support footings one is interested to know the actual accelerations at the module center of gravity. Many Classification Societies allow use of this direct approach, but it appears that this route is seldom taken possibly due to complexities of hydrodynamic analysis. Response quantities of interest for the design of the vessel, such as hull bending moment, acceleration, roll angle etc., are selected as the Dominant Load Component (DLC). In general, there are two methods to compute the extreme hydrodynamic response of any DLC, short term method and long term method, the latter being considered as superior and an extension of the former. The wave environment is defined in terms of the probabilities of different sea states at the specific offshore location through a directional scatter diagram. The long-term response refers to the long term Most Probable Extreme Value (MPEV) of the response at a specific probability level of exceedance derived from the short term responses. Usually, the MPEV of the DLC having a Return Period of 100 years, i.e., a probability of occurrence roughly of the order of 10−8.7 is taken as the extreme design response. For each DLC, an equivalent regular wave called the Design Wave is determined which simulates the magnitude of this extreme value of the Dominant Load Component for the purpose of the structural analysis. For the FPU discussed in this paper a detailed 3D Finite Element Model is created and the hydrodynamic loads corresponding to each Design Wave for the DLC are applied for the structural analysis. Gulf of Mexico weather conditions are taken as the operating area. In this paper, selected results from the hydrodynamic approach are reported and compared with similar results from the conventional Rule Based approach. If any difference is found, the possible reasons thereof are discussed. The authors believe that the methodology and results reported in this paper for a specific FPU will help to understand the true behavior of other ship type FPUs for the site specific conditions and the same methodology can be applied for design.


2006 ◽  
Vol 24 (6) ◽  
pp. 484-490 ◽  
Author(s):  
Gaële Ducher ◽  
Nicolas Tournaire ◽  
Anne Meddahi-Pellé ◽  
Claude-Laurent Benhamou ◽  
Daniel Courteix

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.


Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.


2020 ◽  
Vol 29 (4) ◽  
pp. 710-727
Author(s):  
Beula M. Magimairaj ◽  
Naveen K. Nagaraj ◽  
Alexander V. Sergeev ◽  
Natalie J. Benafield

Objectives School-age children with and without parent-reported listening difficulties (LiD) were compared on auditory processing, language, memory, and attention abilities. The objective was to extend what is known so far in the literature about children with LiD by using multiple measures and selective novel measures across the above areas. Design Twenty-six children who were reported by their parents as having LiD and 26 age-matched typically developing children completed clinical tests of auditory processing and multiple measures of language, attention, and memory. All children had normal-range pure-tone hearing thresholds bilaterally. Group differences were examined. Results In addition to significantly poorer speech-perception-in-noise scores, children with LiD had reduced speed and accuracy of word retrieval from long-term memory, poorer short-term memory, sentence recall, and inferencing ability. Statistically significant group differences were of moderate effect size; however, standard test scores of children with LiD were not clinically poor. No statistically significant group differences were observed in attention, working memory capacity, vocabulary, and nonverbal IQ. Conclusions Mild signal-to-noise ratio loss, as reflected by the group mean of children with LiD, supported the children's functional listening problems. In addition, children's relative weakness in select areas of language performance, short-term memory, and long-term memory lexical retrieval speed and accuracy added to previous research on evidence-based areas that need to be evaluated in children with LiD who almost always have heterogenous profiles. Importantly, the functional difficulties faced by children with LiD in relation to their test results indicated, to some extent, that commonly used assessments may not be adequately capturing the children's listening challenges. Supplemental Material https://doi.org/10.23641/asha.12808607


2019 ◽  
Vol 25 ◽  
pp. 114
Author(s):  
Alyssa Dufour ◽  
Setareh Williams ◽  
Richard Weiss ◽  
Elizabeth Samelson

2017 ◽  
Vol 23 ◽  
pp. 50
Author(s):  
Jothydev Kesavadev ◽  
Shashank Joshi ◽  
Banshi Saboo ◽  
Hemant Thacker ◽  
Arun Shankar ◽  
...  

VASA ◽  
2019 ◽  
Vol 48 (4) ◽  
pp. 321-329
Author(s):  
Mariya Kronlage ◽  
Erwin Blessing ◽  
Oliver J. Müller ◽  
Britta Heilmeier ◽  
Hugo A. Katus ◽  
...  

Summary. Background: To assess the impact of short- vs. long-term anticoagulation in addition to standard dual antiplatelet therapy (DAPT) upon endovascular treatment of (sub)acute thrombembolic occlusions of the lower extremity. Patient and methods: Retrospective analysis was conducted on 202 patients with a thrombembolic occlusion of lower extremities, followed by crirical limb ischemia that received endovascular treatment including thrombolysis, mechanical thrombectomy, or a combination of both between 2006 and 2015 at a single center. Following antithrombotic regimes were compared: 1) dual antiplatelet therapy, DAPT for 4 weeks (aspirin 100 mg/d and clopidogrel 75 mg/d) upon intervention, followed by a lifelong single antiplatelet therapy; 2) DAPT plus short term anticoagulation for 4 weeks, followed by a lifelong single antiplatelet therapy; 3) DAPT plus long term anticoagulation for > 4 weeks, followed by a lifelong anticoagulation. Results: Endovascular treatment was associated with high immediate revascularization (> 98 %), as well as overall and amputation-free survival rates (> 85 %), independent from the chosen anticoagulation regime in a two-year follow up, p > 0.05. Anticoagulation in addition to standard antiplatelet therapy had no significant effect on patency or freedom from target lesion revascularization (TLR) 24 months upon index procedure for both thrombotic and embolic occlusions. Severe bleeding complications occurred more often in the long-term anticoagulation group (9.3 % vs. 5.6 % (short-term group) and 6.5 % (DAPT group), p > 0.05). Conclusions: Our observational study demonstrates that the choice of an antithrombotic regime had no impact on the long-term follow-up after endovascular treatment of acute thrombembolic limb ischemia whereas prolonged anticoagulation was associated with a nominal increase in severe bleeding complications.


GeroPsych ◽  
2013 ◽  
Vol 26 (3) ◽  
pp. 185-199 ◽  
Author(s):  
Christina Röcke ◽  
Annette Brose

Whereas subjective well-being remains relatively stable across adulthood, emotional experiences show remarkable short-term variability, with younger and older adults differing in both amount and correlates. Repeatedly assessed affect data captures both the dynamics and stability as well as stabilization that may indicate emotion-regulatory processes. The article reviews (1) research approaches to intraindividual affect variability, (2) functional implications of affect variability, and (3) age differences in affect variability. Based on this review, we discuss how the broader literature on emotional aging can be better integrated with theories and concepts of intraindividual affect variability by using appropriate methodological approaches. Finally, we show how a better understanding of affect variability and its underlying processes could contribute to the long-term stabilization of well-being in old age.


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