Exogenous insulin-like growth factor 1 attenuates acute ischemic stroke-induced spatial memory impairment via modulating inflammatory response and tau phosphorylation

Neuropeptides ◽  
2020 ◽  
Vol 83 ◽  
pp. 102082
Author(s):  
Wenjin Yang ◽  
Gaoyi Li ◽  
Ke Cao ◽  
Peng Ma ◽  
Yijun Guo ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Inflammatory Response ◽  
Spatial Memory ◽  
Acute Ischemic Stroke ◽  
Memory Impairment ◽  
Tau Phosphorylation ◽  
Insulin Like Growth Factor ◽  
Exogenous Insulin

scholarly journals Insulin-Like Growth Factor-1 as a Prognostic Marker in Patients with Acute Ischemic Stroke

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99186 ◽  
Author(s):  
Jian-Hua Tang ◽  
Li-Li Ma ◽  
Tian-Xia Yu ◽  
Juan Zheng ◽  
Hui-Juan Zhang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Prognostic Marker ◽  
Insulin Like Growth Factor

scholarly journals Association between Serum Insulin-Like Growth Factor-1 and Neurological Severity in Acute Ischemic Stroke

2021 ◽  
Vol 17 (2) ◽  
pp. 206
Author(s):  
Jeeun Lee ◽  
Jeongjae Lee ◽  
Minwoo Lee ◽  
Jae-Sung Lim ◽  
Jin Hyouk Kim ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Serum Insulin ◽  
Insulin Like Growth Factor

scholarly journals Exploring the potential value of miR-148b-3p, miR-151b and miR-27b-3p as biomarkers in acute ischemic stroke

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Xiuli Cheng ◽  
Pengcheng Kan ◽  
Zhuolin Ma ◽  
Yaru Wang ◽  
Wen Song ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Roc Curve ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Healthy Controls ◽  
Insulin Like Growth Factor ◽  
Stroke Patients ◽  
Diagnostic Biomarkers

Cerebrovascular disease is the main cause of death in the world. Here, we explored whether circulating serum miR-148b-3p, miR-151b and miR-27b-3p could be as potential diagnostic biomarkers for diagnosing acute ischemic stroke. Seventy-seven IS patients and forty-two healthy controls matched for age and sex were enrolled in the present study. Blood samples were drawn from IS patients within the 24 h. The correlation analysis was performed by Spearman. The ability to distinguish patients from healthy controls was determined by receiver operating characteristic (ROC) curve. The expression of circulating serum miR-148b-3p was significantly decreased, whereas miR-151b and miR-27b-3p were elevated significantly compared with controls. ROC analysis showed area under the ROC curve (AUC) of miR-148b-3p, miR-151b and miR-27b-3p to be 0.6647, 0.6852 and 0.6657, respectively. While the AUC increased to 0.8103 for the combination of miR-148b-3p and miR-27b-3p. Blood miR-151b level was negatively correlated with insulin-like growth factor-1 (IGF-1), and miR-27b-3p level was negatively correlated with IGF-1 and insulin-like growth factor binding protein-3, respectively. Our findings suggest that miR-148b-3p, miR-151b and miR-27b-3p may serve as blood-based biomarkers for diagnosing ischemic stroke patients, and the combination of miR-148b-3p and miR-27b-3p may be more powerful.

scholarly journals Insulin-Like Growth Factor-1 in Acute Ischemic Stroke

2018 ◽  
Vol 54 (1) ◽  
Author(s):  
Hala Shaheen ◽  
Sayed Sobhy ◽  
Sherine El Mously ◽  
Manal Niazi ◽  
Mohammed Gomaa
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Insulin Like Growth Factor

scholarly journals Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke

2015 ◽  
Vol 6 (4) ◽  
pp. 264-275 ◽  
Author(s):  
Vasileios-Arsenios Lioutas ◽  
Freddy Alfaro-Martinez ◽  
Francisco Bedoya ◽  
Chen-Chih Chung ◽  
Daniela A. Pimentel ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Insulin Like Growth Factor ◽  
Intranasal Insulin

Abstract T P130: High Serum Insulin-Like Growth Factor 1 is Associated with Lower Risk of Ischemic Stroke: The Framingham Heart Study

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Hamidreza Saber ◽  
Jayandra J Himali ◽  
Alexa Beiser ◽  
Ashkan Shoamanesh ◽  
Alexandra Pikula ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Lower Risk ◽  
Serum Insulin ◽  
High Serum ◽  
Community Dwelling ◽  
Insulin Like Growth Factor ◽  
Original Cohort ◽  
Cross Sectional ◽  
Cox Models

Background: Insulin-like growth factor 1 (IGF-1), reduces progression of atherosclerosis and in cross-sectional studies low circulating IGF-1 is associated with increased carotid intima-media thickness. Yet, prospective data linking IGF-1 levels to development of stroke remain sparse and inconsistent. We related circulating IGF-1 levels to risk of incident stroke in a community-dwelling sample. Methods: Serum IGF-1 levels were assayed in 757 stroke-free participants (age 79+5 years, 62% women) from the Framingham original cohort (1990-1994), and related to prospectively ascertained, incident all-stroke and ischemic stroke using Cox models. Results: During a mean follow-up of 10.2 years in 757 participants, 119 developed stroke including 99 with ischemic stroke. After adjustment for age and sex, higher log-IGF1 levels were associated with a lower risk of incident ischemic stroke [hazard ratio (HR): 0.79, 95% confidence interval (CI): 0.63- 0.99, p=0.043]. There was a threshold effect with subjects in the lowest quintile of IGF-1 levels having 2.56-fold higher risk of incident ischemic stroke (95% CI: 1.20, 5.45, p=0.015) compared to all others. We observed significant interaction between diabetes and IGF1 in their relation to ischemic stroke (p=0.016). In pre-specified subgroup analyses the effect was restricted to persons with diabetes and central obesity (waist-to-hip ratio in top quartile) in whom each SD increase in IGF-1 was associated with a 61% (HR: 0.39, 95%CI: 0.20-0.78, p=0.007), and 41% (HR: 0.59, 95%CI: 0.37- 0.95, p=0.031) lower risk of incident ischemic stroke, respectively. Results were similar for all-stroke. Conclusions: IGF-1 may have a protective role in the pathogenesis of ischemic stroke among persons with insulin resistance as manifested by diabetes and/or obesity.

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