scholarly journals Association between Serum Insulin-Like Growth Factor-1 and Neurological Severity in Acute Ischemic Stroke

2021 ◽  
Vol 17 (2) ◽  
pp. 206
Author(s):  
Jeeun Lee ◽  
Jeongjae Lee ◽  
Minwoo Lee ◽  
Jae-Sung Lim ◽  
Jin Hyouk Kim ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Serum Insulin ◽  
Insulin Like Growth Factor

Abstract T P130: High Serum Insulin-Like Growth Factor 1 is Associated with Lower Risk of Ischemic Stroke: The Framingham Heart Study

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Hamidreza Saber ◽  
Jayandra J Himali ◽  
Alexa Beiser ◽  
Ashkan Shoamanesh ◽  
Alexandra Pikula ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Lower Risk ◽  
Serum Insulin ◽  
High Serum ◽  
Community Dwelling ◽  
Insulin Like Growth Factor ◽  
Original Cohort ◽  
Cross Sectional ◽  
Cox Models

Background: Insulin-like growth factor 1 (IGF-1), reduces progression of atherosclerosis and in cross-sectional studies low circulating IGF-1 is associated with increased carotid intima-media thickness. Yet, prospective data linking IGF-1 levels to development of stroke remain sparse and inconsistent. We related circulating IGF-1 levels to risk of incident stroke in a community-dwelling sample. Methods: Serum IGF-1 levels were assayed in 757 stroke-free participants (age 79+5 years, 62% women) from the Framingham original cohort (1990-1994), and related to prospectively ascertained, incident all-stroke and ischemic stroke using Cox models. Results: During a mean follow-up of 10.2 years in 757 participants, 119 developed stroke including 99 with ischemic stroke. After adjustment for age and sex, higher log-IGF1 levels were associated with a lower risk of incident ischemic stroke [hazard ratio (HR): 0.79, 95% confidence interval (CI): 0.63- 0.99, p=0.043]. There was a threshold effect with subjects in the lowest quintile of IGF-1 levels having 2.56-fold higher risk of incident ischemic stroke (95% CI: 1.20, 5.45, p=0.015) compared to all others. We observed significant interaction between diabetes and IGF1 in their relation to ischemic stroke (p=0.016). In pre-specified subgroup analyses the effect was restricted to persons with diabetes and central obesity (waist-to-hip ratio in top quartile) in whom each SD increase in IGF-1 was associated with a 61% (HR: 0.39, 95%CI: 0.20-0.78, p=0.007), and 41% (HR: 0.59, 95%CI: 0.37- 0.95, p=0.031) lower risk of incident ischemic stroke, respectively. Results were similar for all-stroke. Conclusions: IGF-1 may have a protective role in the pathogenesis of ischemic stroke among persons with insulin resistance as manifested by diabetes and/or obesity.

scholarly journals Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke

Stroke ◽  
2017 ◽  
Vol 48 (7) ◽  
pp. 1760-1765 ◽  
Author(s):  
Hamidreza Saber ◽  
Jayandra J. Himali ◽  
Alexa S. Beiser ◽  
Ashkan Shoamanesh ◽  
Aleksandra Pikula ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Serum Insulin ◽  
Insulin Like Growth Factor

scholarly journals The Relationship between Serum Insulin-Like Growth Factor I Levels and Ischemic Stroke Risk

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94845 ◽  
Author(s):  
Xiang Dong ◽  
Geng Chang ◽  
Xiao-Fei Ji ◽  
Ding-Bo Tao ◽  
Ying-Xin Wang
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Stroke Risk ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Ischemic Stroke Risk ◽  
Growth Factor I ◽  
The Relationship

scholarly journals Insulin-Like Growth Factor-1 as a Prognostic Marker in Patients with Acute Ischemic Stroke

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99186 ◽  
Author(s):  
Jian-Hua Tang ◽  
Li-Li Ma ◽  
Tian-Xia Yu ◽  
Juan Zheng ◽  
Hui-Juan Zhang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Prognostic Marker ◽  
Insulin Like Growth Factor

scholarly journals Exploring the potential value of miR-148b-3p, miR-151b and miR-27b-3p as biomarkers in acute ischemic stroke

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Xiuli Cheng ◽  
Pengcheng Kan ◽  
Zhuolin Ma ◽  
Yaru Wang ◽  
Wen Song ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Roc Curve ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Healthy Controls ◽  
Insulin Like Growth Factor ◽  
Stroke Patients ◽  
Diagnostic Biomarkers

Cerebrovascular disease is the main cause of death in the world. Here, we explored whether circulating serum miR-148b-3p, miR-151b and miR-27b-3p could be as potential diagnostic biomarkers for diagnosing acute ischemic stroke. Seventy-seven IS patients and forty-two healthy controls matched for age and sex were enrolled in the present study. Blood samples were drawn from IS patients within the 24 h. The correlation analysis was performed by Spearman. The ability to distinguish patients from healthy controls was determined by receiver operating characteristic (ROC) curve. The expression of circulating serum miR-148b-3p was significantly decreased, whereas miR-151b and miR-27b-3p were elevated significantly compared with controls. ROC analysis showed area under the ROC curve (AUC) of miR-148b-3p, miR-151b and miR-27b-3p to be 0.6647, 0.6852 and 0.6657, respectively. While the AUC increased to 0.8103 for the combination of miR-148b-3p and miR-27b-3p. Blood miR-151b level was negatively correlated with insulin-like growth factor-1 (IGF-1), and miR-27b-3p level was negatively correlated with IGF-1 and insulin-like growth factor binding protein-3, respectively. Our findings suggest that miR-148b-3p, miR-151b and miR-27b-3p may serve as blood-based biomarkers for diagnosing ischemic stroke patients, and the combination of miR-148b-3p and miR-27b-3p may be more powerful.

scholarly journals Insulin-Like Growth Factor-1 in Acute Ischemic Stroke

2018 ◽  
Vol 54 (1) ◽  
Author(s):  
Hala Shaheen ◽  
Sayed Sobhy ◽  
Sherine El Mously ◽  
Manal Niazi ◽  
Mohammed Gomaa
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Insulin Like Growth Factor

scholarly journals Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke

2015 ◽  
Vol 6 (4) ◽  
pp. 264-275 ◽  
Author(s):  
Vasileios-Arsenios Lioutas ◽  
Freddy Alfaro-Martinez ◽  
Francisco Bedoya ◽  
Chen-Chih Chung ◽  
Daniela A. Pimentel ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Acute Ischemic Stroke ◽  
Insulin Like Growth Factor ◽  
Intranasal Insulin

scholarly journals Association Between Levels of Serum Insulin-like Growth Factor I and Functional Recovery, Mortality, and Recurrent Stroke at a 7-year Follow-up

2019 ◽  
Vol 128 (05) ◽  
pp. 303-310 ◽  
Author(s):  
N. David Åberg ◽  
Daniel Åberg ◽  
Cecilia Lagging ◽  
Lukas Holmegaard ◽  
Petra Redfors ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Functional Recovery ◽  
Recurrent Stroke ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Post Stroke ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Abstract Background The association of serum insulin-like growth factor I (s-IGF-I) with favorable outcome after ischemic stroke (IS) beyond 2 years is unknown. We investigated whether the levels of s-IGF-I 3 months post-stroke were associated with functional recovery up to 7 years after IS, considering also mortality and recurrent strokes. Methods Patients (N=324; 65% males; mean age, 55 years) with s-IGF-I levels assessed 3 months after the index IS were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). The modified Rankin Scale (mRS) was used to evaluate outcomes at 3 months, 2 and 7 years after IS, and recovery was defined as an improvement, no change, or deterioration in the shifts of mRS score. Baseline stroke severity was determined using the National Institutes of Health Stroke Scale (NIHSS). Results The mRS score distributions were better in the above-median s-IGF-I group (>146.7 ng/ml). The s-IGF-I level was not associated with recurrent stroke (N=79) or death (N=44), although it correlated with recovery (r=0.12, P=0.035). In the regression analysis, s-IGF-I associated with recovery between 3 months and 7 years (but not between 2 and 7 years). The associations did not withstand adjustment for age and sex. For comparison, the corresponding associations between 3 months and 2 years withstood all adjustments. Conclusion The association for s-IGF-I with long-term post-stroke recovery persists after 7 years, which is also reflected in the mRS score distributions at all time-points. The effects are however modest, and not driven by mortality or recurrent stroke.

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