Effect of vitamin D supplementation on endothelial function – An updated systematic review with meta-analysis and meta-regression

AbstractThis systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to summarize the effect of vitamin D supplementation on endothelial function among people with metabolic syndrome and related disorders. Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related RCTs published up 20th May 2018. To check heterogeneity a Q-test and I2 statistics were used. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as summary effect size. Twenty-two trials of 931 potential citations were found to be eligible for current meta-analysis. The pooled findings by using random effects model indicated that vitamin D supplementation to individuals with MetS and related disorders significantly increased flow-mediated dilatation (FMD) (SMD=1.10; 95% CI, 0.38, 1.81, p=0.003). However, it did not affect pulse-wave velocity (PWV) (SMD=0.04; 95% CI, –0.25, 0.33, p=0.80) and augmentation index (AI) (SMD=0.07; 95% CI, –0.25, 0.40; p=0.65). Overall, this meta-analysis demonstrated that vitamin D supplementation to patients with metabolic syndrome and related disorders resulted in an improvement in FMD, but did not influence PWV and AI.

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The effect of vitamin D supplementation on mortality and Intensive Care Unit admission of COVID‐19 patients. A systematic review, meta‐analysis and meta‐regression

Diabetes/Metabolism Research and Reviews ◽

10.1002/dmrr.3517 ◽

2021 ◽

Author(s):

Nikolaos Tentolouris ◽

Georgia Samakidou ◽

Ioanna Eleftheriadou ◽

Anastasios Tentolouris ◽

Edward B Jude

Keyword(s):

Systematic Review ◽

Intensive Care Unit ◽

Vitamin D ◽

Intensive Care ◽

Intensive Care Unit Admission ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Meta Regression

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Effects of vitamin D supplementation on endothelial function: a systematic review and meta-analysis of randomised clinical trials

European Journal of Nutrition ◽

10.1007/s00394-016-1159-3 ◽

2016 ◽

Vol 56 (3) ◽

pp. 1095-1104 ◽

Cited By ~ 23

Author(s):

Azizah Mat Hussin ◽

Ammar W. Ashor ◽

Inez Schoenmakers ◽

Tom Hill ◽

John C. Mathers ◽

...

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Clinical Trials ◽

Endothelial Function ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Randomised Clinical Trials

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Faculty Opinions recommendation of The effects of vitamin D supplementation on muscle strength and mobility in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736917149.793580285 ◽

2020 ◽

Author(s):

Rebecca Mason

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Muscle Strength ◽

Postmenopausal Women ◽

Randomised Controlled Trials ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Controlled Trials ◽

Randomised Controlled

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Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis

Journal of Endocrinological Investigation ◽

10.1007/s40618-021-01614-4 ◽

2021 ◽

Cited By ~ 1

Author(s):

R. Pal ◽

M. Banerjee ◽

S. K. Bhadada ◽

A. J. Shetty ◽

B. Singh ◽

...

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Clinical Outcomes ◽

Meta Analysis ◽

Vitamin D Supplementation

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Vitamin D in Basketball Players: Current Evidence and Future Directions

Sports Health A Multidisciplinary Approach ◽

10.1177/19417381211019343 ◽

2021 ◽

pp. 194173812110193

Author(s):

Emilija Stojanović ◽

Dragan Radovanović ◽

Tamara Hew-Butler ◽

Dušan Hamar ◽

Vladimir Jakovljević

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Body Composition ◽

Physical Performance ◽

Bone Health ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Current Evidence ◽

Basketball Players ◽

Level Of Evidence

Context: Despite growing interest in quantifying and correcting vitamin D inadequacy in basketball players, a critical synthesis of these data is yet to be performed to overcome the low generalizability of findings from individual studies. Objective: To provide a comprehensive analysis of data in basketball pertaining to (1) the prevalence of vitamin D inadequacy; (2) the effects of vitamin D supplementation on 25-hydroxyvitamin D [25(OH)D] concentration (and its association with body composition), bone health, and performance; and (3) crucial aspects that warrant further investigation. Data Sources: PubMed, MEDLINE, ERIC, Google Scholar, SCIndex, and ScienceDirect databases were searched. Study Selection: After screening, 15 studies were included in the systematic review and meta-analysis. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 3. Data Extraction: The prevalence of vitamin D inadequacy, serum 25(OH)D, body composition, stress fractures, and physical performance were extracted. Results: The pooled prevalence of vitamin D inadequacy for 527 basketball players in 14 studies was 77% ( P < 0.001; 95% CI, 0.70-0.84). Supplementation with 4000 IU/d and 4000 IU/wk (absolute mean difference [AMD]: 25.39 nmol/L; P < 0.001; 95% CI, 13.44-37.33), as well as 10,000 IU/d (AMD: 100.01; P < 0.001; 95% CI, 70.39-129.63) vitamin D restored 25(OH)D to normal concentrations. Body composition data revealed inverse correlations between changes in serum 25(OH)D (from pre- to postsupplementation) and body fat ( r = −0.80; very large). Data concerning positive impacts of vitamin D supplementation on bone health and physical performance remain sparse. Conclusion: The high proportion of vitamin D inadequacy underscores the need to screen for serum 25(OH)D in basketball players. Although supplementation restored vitamin D sufficiency, the beneficial effects on bone health and physical performance remain sparse. Adiposity can modulate 25(OH)D response to supplementation.

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