Vitamin D in Basketball Players: Current Evidence and Future Directions

Context: Despite growing interest in quantifying and correcting vitamin D inadequacy in basketball players, a critical synthesis of these data is yet to be performed to overcome the low generalizability of findings from individual studies. Objective: To provide a comprehensive analysis of data in basketball pertaining to (1) the prevalence of vitamin D inadequacy; (2) the effects of vitamin D supplementation on 25-hydroxyvitamin D [25(OH)D] concentration (and its association with body composition), bone health, and performance; and (3) crucial aspects that warrant further investigation. Data Sources: PubMed, MEDLINE, ERIC, Google Scholar, SCIndex, and ScienceDirect databases were searched. Study Selection: After screening, 15 studies were included in the systematic review and meta-analysis. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 3. Data Extraction: The prevalence of vitamin D inadequacy, serum 25(OH)D, body composition, stress fractures, and physical performance were extracted. Results: The pooled prevalence of vitamin D inadequacy for 527 basketball players in 14 studies was 77% ( P < 0.001; 95% CI, 0.70-0.84). Supplementation with 4000 IU/d and 4000 IU/wk (absolute mean difference [AMD]: 25.39 nmol/L; P < 0.001; 95% CI, 13.44-37.33), as well as 10,000 IU/d (AMD: 100.01; P < 0.001; 95% CI, 70.39-129.63) vitamin D restored 25(OH)D to normal concentrations. Body composition data revealed inverse correlations between changes in serum 25(OH)D (from pre- to postsupplementation) and body fat ( r = −0.80; very large). Data concerning positive impacts of vitamin D supplementation on bone health and physical performance remain sparse. Conclusion: The high proportion of vitamin D inadequacy underscores the need to screen for serum 25(OH)D in basketball players. Although supplementation restored vitamin D sufficiency, the beneficial effects on bone health and physical performance remain sparse. Adiposity can modulate 25(OH)D response to supplementation.

Download Full-text

Effect of Vitamin D Supplementation in Early Life on Children’s Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nutrients ◽

10.3390/nu13020524 ◽

2021 ◽

Vol 13 (2) ◽

pp. 524

Author(s):

Kristine Ma ◽

Shu Qin Wei ◽

Wei Guang Bi ◽

Hope A. Weiler ◽

Shi Wu Wen

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Body Composition ◽

Randomized Controlled Trials ◽

Early Life ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Controlled Trials ◽

Z Score ◽

Randomized Controlled

Background: Vitamin D deficiency during pregnancy or infancy is associated with adverse growth in children. No systematic review has been conducted to summarize available evidence on the effect of vitamin D supplementation in pregnancy and infancy on growth and body composition in children. Objective: We aim to summarize the available evidence on the effect of vitamin D supplementation in pregnancy and infancy on child growth and body composition. Method: A systematic review and meta-analysis were performed on the effects of vitamin D supplementation during early life on children’s growth and body composition (bone, lean and fat). A literature search of randomized controlled trials (RCTs) was conducted to identify relevant studies on the effects of vitamin D supplementation during pregnancy and infancy on children’s body composition (bone, lean and fat) in PubMed, EMBASE and Cochrane Library from inception to 31 December 2020. A Cochrane Risk Assessment Tool was used for quality assessment. The comparison was vitamin D supplementation vs. placebo or standard care. Random-effects and fixed-effect meta-analyses were conducted. The effects are presented as mean differences (MDs) or risk ratios (RRs) with 95% confidence intervals (CIs). Results: A total of 3960 participants from eleven randomized controlled trials were eligible for inclusion. Vitamin D supplementation during pregnancy was associated with higher triceps skinfold thickness (mm) (MD 0.33, 95% CI, 0.12, 0.54; I2 = 34%) in neonates. Vitamin D supplementation during pregnancy or infancy was associated with significantly increased length for age z-score in infants at 1 year of age (MD 0.29, 95% CI, 0.03, 0.54; I2 = 0%), and was associated with lower body mass index (BMI) (kg/m2) (MD −0.19, 95% CI −0.34, −0.04; I2 = 0%) and body mass index z-score (BMIZ) (MD −0.12, 95% CI −0.21, −0.04; I2 = 0%) in offspring at 3–6 years of age. Vitamin D supplementation during early life was not observed to be associated with children’s bone, lean or fat mass. Conclusion: Vitamin D supplementation during pregnancy or infancy may be associated with reduced adiposity in childhood. Further large clinical trials of the effects of vitamin D supplementation on childhood body composition are warranted.

Download Full-text

Vitamin d supplementation and bone health in children with nephrotic syndrome: A systematic review and meta-analysis

Asian Journal of Pediatric Nephrology ◽

10.4103/ajpn.ajpn_35_20 ◽

2021 ◽

Vol 4 (1) ◽

pp. 6

Author(s):

LourdesPaula Real Resontoc ◽

RemaG Caronan-Parallag ◽

TristanMarvin Z. Uy ◽

FranciscoE Anacleto ◽

EricEmmanuel T. Aragon

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Nephrotic Syndrome ◽

Bone Health ◽

Meta Analysis ◽

Vitamin D Supplementation

Download Full-text

MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Acta Endocrinologica ◽

10.1530/eje-16-0391 ◽

2017 ◽

Vol 176 (1) ◽

pp. R1-R14 ◽

Cited By ~ 46

Author(s):

Yvonne H M Krul-Poel ◽

Marieke M ter Wee ◽

Paul Lips ◽

Suat Simsek

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Vitamin D ◽

Glycaemic Control ◽

Fasting Glucose ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Current Evidence ◽

Cochrane Library

Objective Epidemiologic studies suggest that vitamin D status plays a role in glycaemic control in patients with type 2 diabetes. However, intervention studies yielded inconsistent results. The aim of this study is to systematically review the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. Methods Systematic review and meta-analysis. We searched Medline, Embase and the Cochrane Library for RCTs examining the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. A random-effects model meta-analysis was performed to obtain a summarized outcome of vitamin D supplementation on HbA1c, fasting glucose and homeostasis model assessment – insulin resistance (HOMA-IR). Results Twenty-three RCTs were included in this systematic review representing a total of 1797 patients with type 2 diabetes. Mean (± s.d.) change in serum 25-hydroxyvitamin D varied from 1.8 ± 10.2 nmol/L to 80.1 ± 54.0 nmol/L. Nineteen studies included HbA1c as outcome variable. Combining these studies no significant effect in change of HbA1c was seen after vitamin D intervention compared with placebo. A significant effect of vitamin D supplementation was seen on fasting glucose in a subgroup of studies (n = 4) with a mean baseline HbA1c ≥ 8% (64 mmol/mol) (standardized difference in means: 0.36; 95% CI: 0.12–0.61, P = 0.003). Conclusions Current evidence of RCTs does not support short-term vitamin D supplementation in a heterogeneous population with type 2 diabetes. However, in patients with poorly controlled diabetes, a favourable effect of vitamin D is seen on fasting glucose.

Download Full-text

Effects of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentrations and Physical Performance in Athletes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Sports Medicine ◽

10.1007/s40279-017-0749-4 ◽

2017 ◽

Vol 47 (11) ◽

pp. 2323-2339 ◽

Cited By ~ 23

Author(s):

Forough Farrokhyar ◽

Gayathri Sivakumar ◽

Katey Savage ◽

Alex Koziarz ◽

Sahab Jamshidi ◽

...

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Randomized Controlled Trials ◽

Physical Performance ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Controlled Trials ◽

Hydroxyvitamin D ◽

Randomized Controlled ◽

25 Hydroxyvitamin D

Download Full-text

Vitamin D supplementation does not affect serum leptin and adiponectin levels in adults: A systematic review and meta-analysis of randomised controlled trials

Critical Comments in Biomedicine ◽

10.18502/ccb.v1i2.4029 ◽

2020 ◽

Author(s):

Samira J Jafari-Sfidvajani ◽

Fateme Jafari ◽

Sepideh Soltani

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Current Evidence ◽

Controlled Trials ◽

Serum Leptin ◽

Mean Values ◽

Model Studies ◽

Randomised Controlled

Background & aims: It is proposed that vitamin D supplementation might influence serum adipokines level; however, the recent meta-analyses have led to inconsistent results while they had methodological limitations. Therefore, this study aimed to examine the effects of vitamin D supplementation on serum adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs) using a more comprehensive search strategy. Methods: PubMed, Google Scholar, and Scopus were searched to identify related articles published up to November 2017. Mean±standard deviation (SD) of changes in serum adiponectin and leptin were extracted, and the effect sizes were pooled using a random-effects model. Studies with Controlled clinical trials design were eligible. Two reviewers extracted mean values and SDs of the baseline, final and net change values of leptin and adiponectin in the intervention and control groups. Results: The pooled results indicated that vitamin D supplementation affects neither circulating leptin (Hedges’ g = 0.042, 95% CI: -0.294 to 0.378, p = 0. 0.807, n=15) nor adiponectin (Hedges’ g = -0.034, 95% CI: -0.243 to 0.174, p = 0.748, n=18) levels. Subgroup analysis showed that vitamin D supplementation might significantly decrease serum leptin level in patients with end stage renal disease (Hedges’ g = -0.634, 95 % CI: -1.221 to -0.047, p = 0.034). Conclusions: Although the current evidence does not support the significant effect of vitamin D supplementation on adiponectin and leptin levels, further research is required to reach more definitive conclusions.

Download Full-text