Safety and efficacy of common vitamin D supplementation in primary hyperparathyroidism and coexistent vitamin D deficiency and insufficiency: a systematic review and meta-analysis

2021 ◽  
Author(s):  
A. Song ◽  
H. Zhao ◽  
Y. Yang ◽  
S. Liu ◽  
M. Nie ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Primary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Safety And Efficacy

scholarly journals Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Shan Guo ◽  
Reshef Tal ◽  
Haoyu Jiang ◽  
Tao Yuan ◽  
Ying Liu
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Randomized Controlled Trials ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Serum Triglyceride ◽  
Vitamin D Supplementation ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Randomized Controlled

Objective. Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS). We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS. Methods. Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020. The effect of vitamin D supplementation alone on women with PCOS was compared with administration of placebo. The systematic review and meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews (Prospero) as number CRD42020157444. Results. Thirteen randomized controlled trials with 824 patients in total were included. Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo. Vitamin D supplementation group also showed a significantly elevated level of QUICKI. No significant impact was seen on serum triglyceride, total-C, LDL-C, HDL-C, total testosterone, DHEAS, SHBG, or hs-CRP. Subgroup analysis demonstrated that oral vitamin D intake had significantly decreased serum triglyceride and total-C level in women with PCOS who have vitamin D deficiency (serum vitamin D < 20 ng/ml). Conclusion. The findings of the present meta-analysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status.

scholarly journals Vitamin D in Breastfed Infants: Systematic Review of Alternatives to Daily Supplementation

2019 ◽  
Author(s):  
Karen M O'Callaghan ◽  
Mahgol Taghivand ◽  
Anna Zuchniak ◽  
Akpevwe Onoyovwi ◽  
Jill Korsiak ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Vitamin D Supplementation ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Term Infants

ABSTRACT Daily oral vitamin D supplementation (400 IU) is recommended for breastfeeding infants (≤1 y). Recent studies have examined alternative approaches to preventing vitamin D deficiency in this population. This systematic review and meta-analysis aimed to estimate the effects of maternal postpartum (M-PP) or infant intermittent (I-INT) vitamin D supplementation on infant 25-hydroxyvitamin D [25(OH)D] concentrations in comparison to routine direct infant daily (I-D) oral supplementation (400 IU). MEDLINE, MEDLINE In-Process, Embase, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials were searched up to December 2018. Inclusion criteria consisted of published, peer-reviewed, vitamin D intervention trials involving lactating women and/or exclusively or partially breastfed term infants. Two reviewers independently extracted study characteristics (e.g., sample size, intervention dose, and duration and mode of administration) and related biochemical and clinical outcomes. Of 28 included trials, 5 randomized controlled trials were incorporated in meta-analyses examining infant 25(OH)D. Overall, M-PP supplementation resulted in modestly lower infant 25(OH)D compared with I-D supplementation (weighted mean difference = −8.1 nmol/L; 95% CI: −15.4, −0.9; I2 = 45%; P = 0.14; 3 trials), but the 2 most recent trials found M-PP to achieve similar infant 25(OH)D as I-D. Comparison of I-INT with I-D was confined to 2 trials with contradictory findings, and it was considered inappropriate for pooled analysis. Meta-analysis was therefore limited by a small number of eligible trials with variable quality of analytically derived 25(OH)D data and inconsistent reporting of safety outcomes, including effects on calcium homeostasis. Considering all 28 included trials, this systematic review highlights M-PP and I-INT regimens as plausible substitutes for routine daily infant vitamin D supplementation, but evidence remains too weak to support a policy update. Dose-ranging, adequately powered trials are required to establish the efficacy, safety, and feasibility of alternative strategies to prevent vitamin D deficiency in breastfeeding infants. This review was registered with PROSPERO as CRD42017069905.

scholarly journals Vitamin D deficiency or supplementation and the risk of human herpesvirus infections or reactivation: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Liang-Yu Lin ◽  
Ketaki Bhate ◽  
Harriet Forbes ◽  
Liam Smeeth ◽  
Charlotte Warren-Gash ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Herpes Zoster ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Human Herpesvirus ◽  
Vitamin D Supplementation ◽  
Case Control Studies ◽  
Multiple Sclerosis Patients ◽  
Cmv Disease

Abstract Background Vitamin D may protect against respiratory virus infections, but any association with herpesviruses is unclear. Methods We undertook a systematic review of vitamin D deficiency or supplementation and the risk of eight human herpesviruses. Six databases and four gray literature databases were searched for relevant cohort, case-control studies, and clinical trials. Results Ten studies were included, all conducted among immunosuppressed patients. There was no evidence that vitamin D deficiency is associated with CMV disease (pooled risk ratio: 1.06, 95% confidence interval: 0.66,1.7), herpes zoster after transplantation (one study), or HHV-8 among HIV patients (one study). Vitamin D supplementation may decrease herpes zoster among hemodialysis patients (one study) or CMV disease after renal transplantation (one study), but supplementation was not associated with reduced EBV viral load among multiple sclerosis patients (one study). Conclusion Any association between vitamin D and herpesviruses remains inconclusive. Further studies in the general population are needed.

scholarly journals Effects of vitamin D deficiency on neurobehavioural outcomes in children: a systematic review

2020 ◽  
Vol 5 ◽  
pp. 28
Author(s):  
Agnes M. Mutua ◽  
Reagan M. Mogire ◽  
Alison M. Elliott ◽  
Thomas N. Williams ◽  
Emily L. Webb ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Brain Development ◽  
Vitamin D Deficiency ◽  
Motor Development ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Vitamin D Supplementation ◽  
Cochrane Library

Introduction: Vitamin D plays an important role in brain development in experimental studies; however, the effect of vitamin D deficiency on child development remains inadequately characterized. We aimed to estimate the effects of vitamin D deficiency on neurobehavioural outcomes in children up to 18 years of age. Methods: We searched PubMed, EMBASE, PsycINFO, Scopus, Cochrane Library, Web of Science and Open Grey for published studies up to 10th January 2020. We included all studies that assessed the effects of maternal or child vitamin D status or vitamin D supplementation on neurobehavioural outcomes in children. Study findings were synthesized qualitatively as the high level of heterogeneity in study populations and methodologies precluded a quantitative meta-analysis. Results: Our search identified 5,633 studies, of which 31 studies with 31,375 participants from 18 countries were included in the systematic review. Of the studies identified, one was a randomised controlled trial (RCT) of vitamin D supplementation in children, while 30 were observational. The RCT (n=55) reported a beneficial effect of supplementation with lower doses compared to higher doses of vitamin D on motor development. Twelve mother-child studies (n=17,136) and five studies in children (n=1,091) reported an association between low maternal or child 25-hydroxyvitamin D levels and impaired neurobehavioural outcomes in children, while 15 mother-child studies (n=20,778) and eight studies in children (n=7,496) reported no association. Conclusions: Although animal studies point to an effect of vitamin D deficiency on brain development, there are few studies on the effects of vitamin D deficiency on neurobehavioural outcomes in children and their findings are inconsistent. There is a need for well-conducted, adequately powered studies to further determine these effects in children. Registration: PROSPERO ID CRD42018087619; registered on 15 February 2018.

scholarly journals DEFINITION OF VITAMIN D DEFICIENCY IN SCHOOLCHILDREN: SYSTEMATIC REVIEW WITH META-ANALYSIS

2019 ◽  
Vol 56 (4) ◽  
pp. 425-430
Author(s):  
Marcela Almeida LINDEN ◽  
Renata Germano Borges de Oliveira Nascimento FREITAS ◽  
Gabriel HESSEL ◽  
Denise Barbieri MARMO ◽  
Maria Ângela BELLOMO-BRANDÃO
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Mean Value ◽  
Vitamin D Supplementation ◽  
Healthy Children ◽  
Common Definition ◽  
Vitamin D Levels ◽  
Definition Of

ABSTRACT BACKGROUND: Vitamin D deficiency is being recognized as a pandemic due to the volume of people affected by the deficiency and the number of illnesses generated or stimulated by the deficiency. There is a lack of consensus in the literature on what is considered vitamin D deficiency [25(OH)D]. OBJECTIVE: This review brings together the most common levels of 25(OH)D found in healthy schoolchildren and what is considered deficient. METHODS: This systematic review was based on the literature accessed from the electronic databases: MEDLINE, EMBASE, LILACS, SCOPUS and WEB OF SCIENCE. The following descriptors were used in English, Portuguese and Spanish: “Vitamin D”; “Vitamin D deficiency”; “Nutritional Supplements” as well as all their synonyms. The meta-analysis was performed considering the random model. Inclusion criteria: healthy children aged 6 to 12 years, studies that had vitamin D levels, defined vitamin D deficiency. RESULTS: Of the 191 potentially eligible articles, only six articles were included, with 2618 students in total. The mean value of 25(OH)D was estimated at 18.11 ng/mL with 95% confidence interval. Among the articles found, three were considered deficiency levels below 20 ng/mL, one considered below 18 ng/mL, another below 15 ng/mL, and the latter below 11 ng/ mL. The prevalence of vitamin D deficiency among the articles was 48.6%, 7%, 98%, 64.63%, 19.5%, 28.4%, according to each classification used by the same. CONCLUSION: The most common definition in the literature of 25(OH)D deficiency in schoolchildren was at levels below 20 ng/mL. No side effects have been reported in studies that used fortification and/or vitamin D supplementation. Daily supplementation is more effective than seasonal supplementation. However, more studies are needed to define what can be considered as optimal levels of 25(OH)D in children.

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