Higher intake of vitamin B-6 and dairy products and lower intake of green and oolong tea are independently associated with lower serum homocysteine concentration in young Japanese women

2013 ◽  
Vol 33 (8) ◽  
pp. 653-660 ◽  
Author(s):  
Kentaro Murakami ◽  
Satoshi Sasaki ◽  
Kazuhiro Uenishi
2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Pandelis Fotiou ◽  
Athanasios Raptis ◽  
George Apergis ◽  
George Dimitriadis ◽  
Ioannis Vergados ◽  
...  

We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levelsP<0.001, higher prevalence of hyperhomocysteinemiaP<0.001, lower serum folic acidP<0.001, and vitamin B12(P=0.014) levels than those without diabetic retinopathy. Regression analysis revealed that homocysteine was an independent risk factor for diabetic retinopathy and there was a threshold in its serum level (13.7 μmol/L), above which the risk of diabetic retinopathy greatly increases (OR=1.66,P=0.001). Folic acid was associated with decreased odds for diabetic retinopathy (OR=0.73,P<0.001). There was a threshold in serum vitamin B12level (248.4 pg/mL), below which serum homocysteine concentration significantly increases with decreasing serum vitamin B12(P=0.003). Our findings suggest that hyperhomocysteinemia is an independent risk factor for the development and progression of diabetic retinopathy. Decreased serum levels of folic acid and vitamin B12, through raising serum homocysteine concentrations, may also affect the diabetic retinopathy risk.


2009 ◽  
Vol 32 (10) ◽  
pp. 901-905 ◽  
Author(s):  
Katsuko Miyanaga ◽  
Keisuke Fukuo ◽  
Hiroshi Akasaka ◽  
Tomohiro Katsuya ◽  
Rumi Fukada ◽  
...  

2003 ◽  
Vol 52 (2) ◽  
pp. 207-217
Author(s):  
HIRONORI SATO ◽  
AKIRA MIURA ◽  
MANABU SAKAI ◽  
NOBORU TAKAMOTO ◽  
HARUHIKO SATO ◽  
...  

2002 ◽  
Vol 29 (2) ◽  
pp. 519-521 ◽  
Author(s):  
Tatsuya KAMIHAMA ◽  
Hiroyuki IMAMURA ◽  
Chihiro NISHIMURA ◽  
Kazuhiro UCHIDA ◽  
Noriko MIYAMOTO ◽  
...  

2011 ◽  
Vol 58 (4) ◽  
Author(s):  
Amanat Ali ◽  
Mostafa I Waly ◽  
Yahya M Al-Farsi ◽  
Musthafa M Essa ◽  
Marwan M Al-Sharbati ◽  
...  

High serum homocysteine (Hcy) level is regarded as an indicator for impairment of folate-dependent methionine cycle and is associated with oxidative stress. In a case control study, we evaluated eighty 3-5 years old Omani children (40 diagnosed with Autism Spectrum Disorder and 40 their age and gender matched controls) for their fasting serum homocysteine levels as a biomarker of Autism Spectrum Disorder (ASD). Serum folate and vitamin B(12) status were also evaluated. The serum homocysteine was measured using an enzyme immunoassay (EIA) technique whereas folate and vitamin B(12) were measured using an automated random access immune-assay system. The results indicated that mean serum Hcy levels were significantly (P < 0.05) higher in autistic children (20.1 ± 3.3 µmol/L) as compared to controls (9.64 ± 2.1 µmol/L). Significantly (P < 0.05) lower serum folate (1.8 ± 0.4 µg/L) and vitamin B(12) (191.1 ± 0.9 pg/mL) levels were observed in autistic children as compared to controls (6.1 ± 0.6 µg/L and 288.9 ± 1.3 pg/mL, respectively). The levels of homocysteine in autistic children were also much higher as compared to normal reference values (5-15 µmol/L). The results suggest that high fasting serum homocysteine and low folate and vitamin B(12) levels could be used as clinical biomarkers for an early diagnosis and management of ASD.


2004 ◽  
Vol 34 (1) ◽  
pp. 1-8
Author(s):  
Kazuko Hirai ◽  
Yoshimi Ohno ◽  
Yoko Aoki ◽  
Minako Kakesu ◽  
Masako Maeda ◽  
...  

2009 ◽  
Vol 3 ◽  
pp. EHI.S2810 ◽  
Author(s):  
Kentaro Murakami ◽  
Satoshi Sasaki ◽  
Yoshiko Takahashi ◽  
Kazuhiro Uenishi ◽  
Tomoko Watanabe ◽  
...  

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