Long-term Study of Intraocular Pressure Changes in Patients with Human Immunodeficiency Virus Treated with Highly Active Antiretroviral Therapy

Ophthalmology ◽  
2006 ◽  
Vol 113 (3) ◽  
pp. 451-455 ◽  
Author(s):  
Igor Kozak ◽  
Laurie LaBree ◽  
Stanley P. Azen ◽  
Lingyun Cheng ◽  
Nicole L. Reagan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Intraocular Pressure ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Term Study ◽  
Highly Active ◽  
Long Term Study ◽  
Immunodeficiency Virus ◽  
Pressure Changes

scholarly journals Liver function in children with human immunodeficiency virus infection before and after 6 months of highly active antiretroviral therapy

2018 ◽  
Vol 58 (4) ◽  
pp. 159-64
Author(s):  
Eva Jacomina Jemima Sapulete ◽  
I Gusti Ngurah Sanjaya Putra ◽  
Ketut Dewi Kumara Wati ◽  
Hendra Santoso ◽  
I Putu Gede Karyana ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Liver Function ◽  
Highly Active Antiretroviral Therapy ◽  
Aspartate Aminotransferase ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Before And After ◽  
Fluconazole Therapy

Background Highly active antiretroviral therapy (HAART) has resulted in dramatic decreases in morbidity and improved survival rate in human immunodeficiency virus (HIV)-infected patients. Although the risk of morbidity has decreased, it has been replaced by other long-term complications, such as hepatotoxicity. Hepatotoxicity is often reflected in biochemical abnormalities of liver function, such as elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and aspartate aminotransferase-to-platelet ratio index (APRI). Objective To compare liver function spectrum (AST, ALT, and APRI) in HIV-infected children before and after at least 6 months of HAART. Methods This observational study (before and after) was conducted in pediatric patients with HIV infection who received HAART for at least 6 months at Sanglah Hospital, Denpasar. Data were collected from medical records. Results Forty-nine patients were observed in this study. The mean AST, ALT, and APRI levels before HAART were higher than after at least 6 months of HAART. Anti-tuberculosis treatment and fluconazole therapy were not confounding factors for AST, ALT, and APRI. Conclusion Liver function spectrum enzyme levels of AST, ALT, and APRI are improved after at least 6 months of HAART.

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