Natural History of Lipid Abnormalities and Fat Redistribution Among Human Immunodeficiency Virus-Infected Children Receiving Long-Term, Protease Inhibitor-Containing, Highly Active Antiretroviral Therapy Regimens

PEDIATRICS ◽  
2004 ◽  
Vol 114 (2) ◽  
pp. e235-e242 ◽  
Author(s):  
P. Taylor ◽  
C. Worrell ◽  
S. M. Steinberg ◽  
R. Hazra ◽  
S. Jankelevich ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Natural History ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Fat Redistribution ◽  
History Of ◽  
Lipid Abnormalities

scholarly journals Liver function in children with human immunodeficiency virus infection before and after 6 months of highly active antiretroviral therapy

2018 ◽  
Vol 58 (4) ◽  
pp. 159-64
Author(s):  
Eva Jacomina Jemima Sapulete ◽  
I Gusti Ngurah Sanjaya Putra ◽  
Ketut Dewi Kumara Wati ◽  
Hendra Santoso ◽  
I Putu Gede Karyana ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Liver Function ◽  
Highly Active Antiretroviral Therapy ◽  
Aspartate Aminotransferase ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Before And After ◽  
Fluconazole Therapy

Background Highly active antiretroviral therapy (HAART) has resulted in dramatic decreases in morbidity and improved survival rate in human immunodeficiency virus (HIV)-infected patients. Although the risk of morbidity has decreased, it has been replaced by other long-term complications, such as hepatotoxicity. Hepatotoxicity is often reflected in biochemical abnormalities of liver function, such as elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and aspartate aminotransferase-to-platelet ratio index (APRI). Objective To compare liver function spectrum (AST, ALT, and APRI) in HIV-infected children before and after at least 6 months of HAART. Methods This observational study (before and after) was conducted in pediatric patients with HIV infection who received HAART for at least 6 months at Sanglah Hospital, Denpasar. Data were collected from medical records. Results Forty-nine patients were observed in this study. The mean AST, ALT, and APRI levels before HAART were higher than after at least 6 months of HAART. Anti-tuberculosis treatment and fluconazole therapy were not confounding factors for AST, ALT, and APRI. Conclusion Liver function spectrum enzyme levels of AST, ALT, and APRI are improved after at least 6 months of HAART.

scholarly journals Synchronous and metachronous malignant melanomas arising in a human immunodeficiency virus-positive patient after the commencement of highly active antiretroviral therapy treatment: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Sharad P. Paul ◽  
Simon Briggs ◽  
Michael Hitchcock
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Previous History ◽  
Case Presentation ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
History Of

Abstract Background We present an unusual case of a patient who developed four melanomas within a few months of diagnosis with human immunodeficiency virus and commencement of highly active antiretroviral therapy therapy. The patient had no previous history of melanoma, and previous skin checks were normal. Case presentation A 50-year-old Caucasian male drainlayer with Fitzpatrick type 2 skin presented for a routine skin examination. He had been diagnosed with human immunodeficiency virus 4 months earlier and commenced on highly active antiretroviral therapy therapy. He was found to have three melanomas (melanoma in situ stage) on excision biopsies, and when he presented for wider excisions of these sites a few weeks later, another new melanoma in situ was found. He had no other medical history of note, and no symptoms to report. He is being followed up 3-monthly. Conclusions This case of a human immunodeficiency virus-positive person presenting with four cutaneous melanomas—occurring in both synchronous and metachronous fashion within a 4-month period—is being presented both for its uniqueness and also to highlight the increased need for close skin surveillance in human immunodeficiency virus-positive patients.

Sign in / Sign up

Export Citation Format

Share Document