Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19)

Background. We aimed to investigate the symptoms of the dry eye disease (DED) of hospitalized patients with coronavirus disease 2019 (COVID-19). Methods. This cross-sectional, observational study analysis included 91 hospitalized patients with confirmed COVID-19 in Wuhan, China. The Ocular Surface Disease Index (OSDI) and the five-item Dry Eye Questionnaire (DEQ-5) were used to assess the severity of DED symptoms in the patients, and the analysis of variance was used to determine the factors associated with DED. Results. A total of 42 patients consented to complete the investigation (response rate 46.15%). There were 26 (61.90%) patients who were diagnosed with DED symptoms by OSDI, and there were 28 (66.67%) patients with DED symptoms who were diagnosed by DEQ-5 score. For the biochemical tests, the patients with DED symptoms had lower aspartate aminotransferase (AST) levels compared to those with no DED symptoms (20.86 vs. 42.14, p = 0.04 ). Further analysis showed that a previous history of cardiac or stroke disease ( p = 0.02 ) and typical symptoms of muscle soreness ( p = 0.03 ) were significantly different among the four DED symptoms groups on the basis of OSDI scores. The contributing factors of OSDI were mainly focused on visual function and environmental triggers. Conclusion. The incidence of DED symptoms is higher in hospitalized patients with COVID-19. The serum AST levels, history of cardiac or stroke disease, and the typical symptoms of muscle soreness may be the main impact factors on DED symptoms. We also need to pay more attention to the visual function and environmental triggers of hospitalized patients with COVID-19.

Download Full-text

Long-term Natural History of Dry Eye Disease from the Patient's Perspective

Ophthalmology ◽

10.1016/j.ophtha.2015.10.011 ◽

2016 ◽

Vol 123 (2) ◽

pp. 425-433 ◽

Cited By ~ 23

Author(s):

Jeffrey P. Lienert ◽

Laura Tarko ◽

Miki Uchino ◽

William G. Christen ◽

Debra A. Schaumberg

Keyword(s):

Natural History ◽

Dry Eye ◽

Dry Eye Disease ◽

Eye Disease ◽

Patient’S Perspective ◽

History Of

Download Full-text

The negative effects of dry eye disease on quality of life and visual function

TURKISH JOURNAL OF MEDICAL SCIENCES ◽

10.3906/sag-2002-143 ◽

2020 ◽

Vol 50 (7) ◽

pp. 1611-1615

Author(s):

Lee W. Guo O.D ◽

Esen K. AKPEK

Keyword(s):

Quality Of Life ◽

Dry Eye ◽

Visual Function ◽

Dry Eye Disease ◽

Treatment Modalities ◽

Eye Disease ◽

Negative Effects ◽

Ocular Discomfort ◽

Novel Devices

In recent years, dry eye has become a hot topic within ophthalmology and optometry, especially in regards to new frontiers in treatment modalities which include novel devices, procedures, and medications. However, some of the more understudied areas in dry eye involve its impact on quality of life. Although ocular discomfort symptoms are well known to be associated with dry eye, its negative effects on visual function remain underrecognized. This paper reviews these topics within the currently published literature to heighten awareness among clinicians.

Download Full-text

Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan

Journal of Clinical Medicine ◽

10.3390/jcm8081120 ◽

2019 ◽

Vol 8 (8) ◽

pp. 1120 ◽

Cited By ~ 1

Author(s):

Miki Uchino ◽

Norihiko Yokoi ◽

Motoko Kawashima ◽

Yamanishi Ryutaro ◽

Yuichi Uchino ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Dry Eye ◽

Past History ◽

Significant Risk ◽

Significant Risk Factor ◽

Dry Eye Disease ◽

Eye Disease ◽

History Of

Despite the importance of dry eye disease (DED) treatment, the rate of DED treatment discontinuation, especially discontinuation of ophthalmic follow-up, remains unknown. This study aimed to assess the prevalence and risk factors of ophthalmic follow-up discontinuation for DED. A cross-sectional survey of 1030 participants was conducted using a self-administered web-survey instrument. We collected lifestyle information, history of DED diagnosis, types of treatment, frequency of eye-drop usage, symptoms, and the reasons for discontinuing treatment. Statistical analyses including logistic regression were used to evaluate the risk factors of discontinuing ophthalmic follow-up for DED. A past history of clinical DED diagnosis was reported by 155 (15.0%) subjects. Of those, 130 had persistent DED, and 88 (67.7%) of the subjects reported discontinuation of ophthalmic follow-up for DED. The most prevalent reasons for ophthalmic follow-up discontinuation were time restrictions, followed by dissatisfaction with the DED treatment. Duration after DED diagnosis was the only significant risk factor for discontinuing ophthalmic follow-up after adjusting for age and sex (odds ratio = 1.09, 95% confidence interval = 1.02–1.17, p = 0.009). In conclusion, longer DED duration after diagnosis was a significant risk factor for discontinuing ophthalmic follow-up for DED. This study showed that DED ophthalmic follow-up discontinuation involves both medical and non-medical reasons. Clinicians need to be aware of them, and preventative effort is needed to avoid discontinuation.

Download Full-text

Patient-reported burden of dry eye disease in the UK: a cross-sectional web-based survey

BMJ Open ◽

10.1136/bmjopen-2020-039209 ◽

2021 ◽

Vol 11 (3) ◽

pp. e039209

Author(s):

Parwez Hossain ◽

Csaba Siffel ◽

Corey Joseph ◽

Juliette Meunier ◽

Jessica T. Markowitz ◽

...

Keyword(s):

Dry Eye ◽

Visual Function ◽

Work Productivity ◽

Dry Eye Disease ◽

Eye Disease ◽

Activity Limitations ◽

Life Questionnaire ◽

Cross Sectional ◽

Web Based ◽

The Impact

ObjectivesTo compare sociodemographics and vision-related quality of life (QoL) of individuals with or without dry eye disease (DED); and to explore the impact of DED symptom severity on visual function, activity limitations and work productivity.DesignCross-sectional web-based survey.SettingGeneral UK population.ParticipantsAdults ≥18 years with (N=1002) or without (N=1003) self-reported DED recruited through email and screened.Main outcome measuresAll participants completed the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25), with six additional questions (items A3–A8), and the EuroQol 5 dimensions 5 levels. DED participants also completed Impact of Dry Eye on Everyday Life questionnaire, 5-item Dry Eye Questionnaire and the Standardised Patient Evaluation of Eye Dryness questionnaire along with the Ocular Comfort Index, Work Productivity and Activity Impairment and the Eye Dryness Score (EDS), a Visual Analogue Scale.ResultsBaseline demographic and clinical characteristics were similar in participants with versus without DED (mean age, 55.2 vs 55.0 years; 61.8% vs 61.0% women, respectively) based on recruitment targets. Scores were derived from NEI VFQ-25 using the new 28-item revised VFQ (VFQ-28R) scoring. Mean (SD) VFQ-28R scores were lower in participants with versus without DED, indicating worse functioning (activity limitations, 73.3 (12.3) vs 84.4 (12.3); socioemotional functioning, 75.3 (21.5) vs 90.3 (16.2); total score, 71.6 (12.8) vs 83.6 (12.6)). Higher percentages of problems/inability to do activities were observed among those with versus without DED. The impact of DED on visual function was worse for participants with more severe DED symptoms, as assessed by EDS. In addition, a higher EDS was associated with worse symptoms on common DED scales and a worse impact on work productivity.ConclusionsDED symptoms were associated with negative effects on visual function, activities and work productivity, whereas worse DED symptoms had a greater impact on vision-related QoL and work productivity.

Download Full-text

Refractory dry eye disease associated with Meige’s syndrome induced by long-term use of an atypical antipsychotic

BMC Ophthalmology ◽

10.1186/s12886-020-01738-w ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Ji Eun Kim ◽

Ji Won Jung

Keyword(s):

Atypical Antipsychotic ◽

Dry Eye ◽

Dry Eye Disease ◽

Eye Disease ◽

Psychotic Symptoms ◽

Oromandibular Dystonia ◽

Drug Induced ◽

Involuntary Movements ◽

Body Sensation ◽

History Of

Abstract Background We report a case of Meige’s syndrome induced by an atypical antipsychotic (blonanserin) that presented with refractory dry eye disease. Case presentation A 37-year-old woman with a 6-month history of foreign body sensation in the eyes and difficulty in opening her eyes was treated at a local clinic for dry eye disease. Despite this treatment, her symptoms did not improve and she was transferred to our attention. Our assessment revealed involuntary movements of her eyelids accompanied by repetitive pursing of her lips. She had been undergoing treatment with blonanserin for 5 years for schizophrenia. She was diagnosed with drug-induced Meige’s syndrome after a psychiatric and neurological consultation. After a 2-month gradual dose reduction and discontinuing blonanserin, involuntary movements of the eyelids with oromandibular dystonia were resolved. Three months after discontinuing blonanserin, there was no recurrence of symptoms, and she had no exacerbation of psychotic symptoms. Conclusions In patients with refractory dry eye disease, especially those with involuntary movements of the eyelids with oromandibular dystonia, it is important to ask about their psychotropic medications and to consider the possibility of drug-induced Meige’s syndrome and discontinuation of medications, if possible.

Download Full-text