The abruptly auto-braiding property of the Bessel beam superimposed with circular Airy beam

2022 ◽  
Vol 148 ◽  
pp. 107715
Author(s):  
Zhifang Qiu ◽  
Bingsong Cao ◽  
Tong Li ◽  
Donghui Shen ◽  
Kaikai Huang ◽  
...  
Keyword(s):  
2021 ◽  
Vol 9 ◽  
Author(s):  
Yu-Xuan Ren ◽  
Hongsen He ◽  
Huajun Tang ◽  
Kenneth K. Y. Wong

The light propagation in the medium normally experiences diffraction, dispersion, and scattering. Studying the light propagation is a century-old problem as the photons may attenuate and wander. We start from the fundamental concepts of the non-diffracting beams, and examples of the non-diffracting beams include but are not limited to the Bessel beam, Airy beam, and Mathieu beam. Then, we discuss the biomedical applications of the non-diffracting beams, focusing on linear and nonlinear imaging, e.g., light-sheet fluorescence microscopy and two-photon fluorescence microscopy. The non-diffracting photons may provide scattering resilient imaging and fast speed in the volumetric two-photon fluorescence microscopy. The non-diffracting Bessel beam and the Airy beam have been successfully used in volumetric imaging applications with faster speed since a single 2D scan provides information in the whole volume that adopted 3D scan in traditional scanning microscopy. This is a significant advancement in imaging applications with sparse sample structures, especially in neuron imaging. Moreover, the fine axial resolution is enabled by the self-accelerating Airy beams combined with deep learning algorithms. These additional features to the existing microscopy directly realize a great advantage over the field, especially for recording the ultrafast neuronal activities, including the calcium voltage signal recording. Nonetheless, with the illumination of dual Bessel beams at non-identical orders, the transverse resolution can also be improved by the concept of image subtraction, which would provide clearer images in neuronal imaging.


Author(s):  
R. Kadlimatti ◽  
H. Gaddam ◽  
H. Larocque ◽  
E. Karimi ◽  
R.W. Boyd ◽  
...  
Keyword(s):  

2021 ◽  
pp. 100106
Author(s):  
Yongjie Jia ◽  
Renxian Li ◽  
Wenze Zhuang ◽  
Jiarui Liang

Nanophotonics ◽  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Qingqing Cheng ◽  
Juncheng Wang ◽  
Ling Ma ◽  
Zhixiong Shen ◽  
Jing Zhang ◽  
...  

AbstractAiry beams exhibit intriguing properties such as nonspreading, self-bending, and self-healing and have attracted considerable recent interest because of their many potential applications in photonics, such as to beam focusing, light-sheet microscopy, and biomedical imaging. However, previous approaches to generate Airy beams using photonic structures have suffered from severe chromatic problems arising from strong frequency dispersion of the scatterers. Here, we design and fabricate a metasurface composed of silicon posts for the frequency range 0.4–0.8 THz in transmission mode, and we experimentally demonstrate achromatic Airy beams exhibiting autofocusing properties. We further show numerically that a generated achromatic Airy-beam-based metalens exhibits self-healing properties that are immune to scattering by particles and that it also possesses a larger depth of focus than a traditional metalens. Our results pave the way to the realization of flat photonic devices for applications to noninvasive biomedical imaging and light-sheet microscopy, and we provide a numerical demonstration of a device protocol.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dwaipayan Adhya ◽  
George Chennell ◽  
James A. Crowe ◽  
Eva P. Valencia-Alarcón ◽  
James Seyforth ◽  
...  

Abstract Background The inability to observe relevant biological processes in vivo significantly restricts human neurodevelopmental research. Advances in appropriate in vitro model systems, including patient-specific human brain organoids and human cortical spheroids (hCSs), offer a pragmatic solution to this issue. In particular, hCSs are an accessible method for generating homogenous organoids of dorsal telencephalic fate, which recapitulate key aspects of human corticogenesis, including the formation of neural rosettes—in vitro correlates of the neural tube. These neurogenic niches give rise to neural progenitors that subsequently differentiate into neurons. Studies differentiating induced pluripotent stem cells (hiPSCs) in 2D have linked atypical formation of neural rosettes with neurodevelopmental disorders such as autism spectrum conditions. Thus far, however, conventional methods of tissue preparation in this field limit the ability to image these structures in three-dimensions within intact hCS or other 3D preparations. To overcome this limitation, we have sought to optimise a methodological approach to process hCSs to maximise the utility of a novel Airy-beam light sheet microscope (ALSM) to acquire high resolution volumetric images of internal structures within hCS representative of early developmental time points. Results Conventional approaches to imaging hCS by confocal microscopy were limited in their ability to image effectively into intact spheroids. Conversely, volumetric acquisition by ALSM offered superior imaging through intact, non-clarified, in vitro tissues, in both speed and resolution when compared to conventional confocal imaging systems. Furthermore, optimised immunohistochemistry and optical clearing of hCSs afforded improved imaging at depth. This permitted visualization of the morphology of the inner lumen of neural rosettes. Conclusion We present an optimized methodology that takes advantage of an ALSM system that can rapidly image intact 3D brain organoids at high resolution while retaining a large field of view. This imaging modality can be applied to both non-cleared and cleared in vitro human brain spheroids derived from hiPSCs for precise examination of their internal 3D structures. This process represents a rapid, highly efficient method to examine and quantify in 3D the formation of key structures required for the coordination of neurodevelopmental processes in both health and disease states. We posit that this approach would facilitate investigation of human neurodevelopmental processes in vitro.


2021 ◽  
Vol 11 (2) ◽  
pp. 717
Author(s):  
Boris Knyazev ◽  
Valery Cherkassky ◽  
Oleg Kameshkov

Transformation of a Bessel beam by a lens results in the formation of a “perfect” vortex beam (PVB) in the focal plane of the lens. The PVB has a single-ring cross-section and carries an orbital angular momentum (OAM) equal to the OAM of the “parent” beam. PVBs have numerous applications based on the assumption of their ideal ring-type structure. For instance, we proposed using terahertz PVBs to excite vortex surface plasmon polaritons propagating along cylindrical conductors and the creation of plasmon multiplex communication lines in the future (Comput. Opt. 2019, 43, 992). Recently, we demonstrated the formation of PVBs in the terahertz range using a Bessel beam produced using a spiral binary silicon axicon (Phys. Rev. A 2017, 96, 023846). It was shown that, in that case, the PVB was not annular, but was split into nested spiral segments, which was obviously a consequence of the method of Bessel beam generation. The search for methods of producing perfect beams with characteristics approaching theoretically possible ones is a topical task. Since for the terahertz range, there are no devices like spatial modulators of light in the visible range, the main method for controlling the mode composition of beams is the use of diffractive optical elements. In this work, we investigated the characteristics of perfect beams, the parent beams being quasi-Bessel beams created by three types of diffractive phase axicons made of high-resistivity silicon: binary, kinoform, and “holographic”. The amplitude-phase distributions of the field in real perfect beams were calculated numerically in the approximation of the scalar diffraction theory. An analytical expression was obtained for the case of the binary axicon. It was shown that a distribution closest to an ideal vortex was obtained using a holographic axicon. The resulting distributions were compared with experimental and theoretical distributions of the evanescent field of a plasmon near the gold–zinc sulfide–air surface at different thicknesses of the dielectric layer, and recommendations for experiments were given.


Optik ◽  
2021 ◽  
Vol 229 ◽  
pp. 166295
Author(s):  
Haoran Wang ◽  
Fan Zhang ◽  
Kaiwen Ding ◽  
Ji'an Duan

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Rui-Pin Chen ◽  
Khian-Hooi Chew ◽  
Sailing He
Keyword(s):  

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