Squamous odontogenic tumor like proliferations in dentigerous cyst- a great mimicker

Oral Oncology ◽  
2022 ◽  
Vol 125 ◽  
pp. 105699
Author(s):  
Pratibha Ramani ◽  
Reshma Poothakulath Krishnan ◽  
Deepak Pandiar ◽  
Aklesha Behera ◽  
Abilasha Ramasubramanian
Reports ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 4
Author(s):  
Sawako Ono ◽  
Hotaka Kawai ◽  
Shintaro Sukegawa ◽  
Kiyofumi Takabatake ◽  
Keisuke Nakano ◽  
...  

Primordial odontogenic tumor (POT) is a rare odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla and covered by cuboidal to columnar epithelium. We herein report a case of POT in a 14-year-old boy. Computed tomography (CT) exhibited a round cavity with a defined cortical border circumscribing the tooth of the second molar. However, the gross finding was a solid mass, not a cyst. Histologically, the tumor consisted of dental papillalike myxoid connective tissue covered by columnar epithelium. Therefore, although the clinical diagnosis was dentigerous cyst (DC), we diagnosed POT based on histologic findings. Clinical findings of POT resemble DC, but the clinical behavior of POT is different to DC, such as cortical expansion and root resorption of teeth. Therefore, histological differentiation of POT from DC is critical for accurate diagnosis.


2021 ◽  
Vol 12 (1) ◽  
pp. 134-143
Author(s):  
Merlin Jayaraj ◽  
Pratibha Ramani ◽  
Herald J. Sherlin

Background: Keratocystic odontogenic tumor (KCOT) is an odontogenic lesion which manifests distinct biological behavior. Predominant studies in KCOT attribute this behavior to high epithelial proliferative capacity. Besides, a few studies facet loosely arranged collagen can contribute to the behavior of KCOT. Matrix metalloproteinases (MMP) are enzymes that degrade extracellular matrix components under both physiologic and pathologic conditions. The loosely arranged collagen in connective tissue wall of KCOT could be related to the degree of MMP-9 expression. Aim: To evaluate the arrangement of collagen fibers along with immunoexpression of MMP-9 and to relate to its neoplastic biologic behavior in sporadic cases of KCOT. Materials and Methods: KCOT ( n = 23) and dentigerous cyst (DC) ( n = 15) samples were processed for the following techniques: Masson’s trichrome stain for light microscopy, PMA-PSR stain for confocal microscopy, and MMP-9 for immunohistochemistry. Results: In Masson’s trichrome analysis, correlation of collagen fiber arrangement in the deeper regions with color intensity for KCOT was found to be statistically significant ( P = .033). In confocal microscopy, there was no difference between intensities in KCOT ( P = .990) and DC ( P = .233), respectively. The immunoexpression of MMP-9 in the connective tissue wall of DC (73.3%) was relatively higher than that of KCOT (60.8%). However, on comparison between KCOT and DC in the presence of inflammation, the immunoexpression of MMP-9 was higher in DC (100%) than KCOT (69.9%) and was statistically significant ( P = .028). Conclusion: It was concluded that the loose connective tissue wall in KCOT is because of the inherent nature of the lesion that could facilitate its biologic behavior. If inflammation is present, this could further aggravate the tumorigenic behavior.


Author(s):  
Camila De Oliveira Barbeiro ◽  
Heitor Albergoni Da Silveira ◽  
Darcy Fernandes ◽  
Raphael Carlos Comelli Lia ◽  
Jorge Esquiche Leon ◽  
...  

2015 ◽  
Vol 27 (3) ◽  
Author(s):  
Aris Munandar ◽  
Endang Syamsudin ◽  
Melita Sylvyana ◽  
Kiki Akhmad Rizki

Background. Adenomatoid Odontogenic Tumor (AOT) is a rare tumor of epithelial origin. AOT appears in three clinico-topographic variants: follicular, extrafollicular and peripheral. The AOT was predominantly found in the upper jaw, and rarely found in mandible, especially at anterior mandible. AOT is a tumor of odontogenic epithelium having duct like structures, which may be partly cystic, and in some cases the solid lesion may be present only as masses in the wall of a large cyst. The surgical management of this lesion would be enucleation along with removal of associated impacted tooth. The prognosis for both of them is good and recurrences are very rare after complete removal of the lesion. Purpose. It is important to define final diagnose for AOT due to mimicking with DC in clinically and radiographically finding. Biopsy is still obviously necessary to the final diagnosis. Case. 15-year-old female patients reported with chief complain of swelling in anterior mandible. The swelling beginning 4 years ago, gradually progressed, with no history pain, discharge and patient is complaint about loss of sensation around anterior mandible. Aspiration revealed straw colored fluid thinking in the way of DC. The provisional diagnosis of DC was given due to clinical presentation and radiographic imaging. But the biopsy examination showed AOT due to duct-like epithelial cells was being found. Discussion. The case report illustrates characteristic clinical and radiographic features of follicular variant of AOT mimicking a DC at unusual site that is anterior mandible. AOT is thought to arise from odontogenic epithelium and associated with the impacted tooth. Rightfully AOT is a perfect imitator of DC radiographically as well as histopathologically. It usually clinically misdiagnosed as DC as both have a unilocular, well-defined radiolucency surrounding the crown of an impacted tooth. The mass was enucleated, involved teeth were extracted, and titanium plates are used to avoid pathologist fracture. The patient had uneventful postoperative recovery. Follow up of a year has not shown any evidence of recurrence. Conclusion. Follicular type of OAT could confuse us with DC if the support examination just only clinicaly finding and radiographic examination. This case could not be definitively diagnosed on clinical and radiographic features alone. Biopsy was obviously necessary to the final diagnosis.


2015 ◽  
Vol 1 (1) ◽  
pp. 31-40
Author(s):  
Rino Rusdiono ◽  
Arif Faisal

Odontogenic tumor is a lesion originated from epithelium, ectomesenchymal, or mesenchymal component which still retain part of dental-forming element.A female 20 years old had complaint a mass in the oral cavity and obtructed nasal. Physical examination showed a mass on molar region of the left axillary bone. Diagnostic imaging by using OPG was suspected ameloblastoma, while CT scan concluded as a dentigerous cyst in left maxillary bone. Both of the lesions were cystic  abnormalities, that sometimes very difcult to di?erentiate due to their similarity. Pathological fndings was clear cell odontogenic tumor or clear cell odontogenic carcinoma of tissue mass after resection had been conducted. This case report is proposed because there is a discordance from imaging examination in both OPG and CT Scan with the fnal histopathological examination. CCOC di?erential diagnosis will be outlined here so we can understand the feature of CCOC better in imaging examination to prevent misdiagnosis which can infere further treatment.


2012 ◽  
Vol 3 (6) ◽  
pp. 244 ◽  
Author(s):  
Sunder Goyal ◽  
Soheyl Sheikh ◽  
P Shambulingappa ◽  
Balwinder Singh ◽  
Ravinder Singh ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Massoumeh Zargaran ◽  
Setareh Shojaei

Distinguishing squamous odontogenic tumor-like proliferations (SOTLPs) is important in odontogenic cysts to avoid misinterpretation such as a squamous odontogenic tumor, well-differentiated squamous cell carcinoma, and acanthomatous type of ameloblastoma. This study is aimed at reporting 4 cases of these clinicopathological proliferations in order to shed more light on the importance of distinguishing them from other similar types. 150 odontogenic cysts were studied in which four cases (2.66%) with SOTLPs were identified including 2 radicular cysts, 1 dentigerous cyst, and 1 odontogenic keratocyst. These proliferations were observed in the cysts’ wall particularly adjacent to the epithelial lining. All cysts had inflammation while 3 cases showed budding from the epithelial cyst lining. The findings suggested that lining of odontogenic cysts could be a source of SOTLPs, and inflammation probably played an effective role in their development. Its incidence was 2.66% in the present study. Although SOTLPs are not frequent in odontogenic cysts, their identification is important to prevent wrong histopathologic interpretation and treatment.


2005 ◽  
Vol 69 (12) ◽  
pp. 1685-1688 ◽  
Author(s):  
Miguel Bravo ◽  
David White ◽  
Lili Miles ◽  
Robin Cotton

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Sareh Farhadi ◽  
Fatemeh Shahsavari ◽  
MirMahdi Davardan

Background. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions. This study was aimed to evaluate and compare the density of mast cells in Dentigerous cyst (DC) and Keratocystic odontogenic tumor (KCOT) regarding their different clinical behavior. Method. This study was conducted on 23 and 26 cases of DC and KCOT, respectively. Four-micron sections were prepared for Toluidine blue staining and mast cell densities in two desired cysts were studied. Final data was analyzed via t-test and Mann-Whitney U test method regarding the significant level lower than 0.05. Results. Mast cell densities were significantly higher in KCOTs for deep and superficial layers and both layers (P<0.05). The density of degranulated mast cells in the deeper layers and both layers was significantly higher in KCOTs (P<0.05). However, the density of degranulated mast cells in the superficial layer had no significant difference (P>0.05). Conclusion. It seems that mast cells may be involved in the pathogenesis of KCOT, but, regarding wide range of mast cell’s biologic activities, further investigations are recommended to confirm the issue and prepare the details.


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