Oral administration of trehangelin-A alleviates metabolic disorders caused by a high-fat diet through improvement of lipid metabolism and restored beneficial microbiota

Abnormalities in lipid metabolism cause many diseases, including atherosclerosis. By this study, we proposed to synthesize a novel derivative from piperine and identify its hypolipidemic effect. For this, piperlonguminine acid (GBN-COOH) was synthesized as a piperine derivative from Piper longum Linn. successfully. The molecular structure of the GBN-COOH was confirmed by 13C and 1H NMR, ES-MS methods and it was administered orally to high-fat diet fed rats. Compared with model rats, oral administration of GB-COOH at dose of 10 mg/kg to hyperlipidemic rats could significantly decrease the levels of serum TC, TG, and LDL-C by the amount of 4.93 mm/L, 1.15 mm/L, and 1.11 mm/L, respectively, with increase of HDL-C level from 0.19 mm/L to 0.26 mm/L. Thus, the synthesized piperlonguminine acid could be a useful candidate in the treatment of anti-hyperlipidemia. Шинээр гарган авсан пиперлонгуминины хүчлийн өөх-тосны эсрэг идэвхийн судалгаа Хураангуй: Өөх-тосны солилцооны эмгэгийн үед судасны хатуурал буюу атеросклероз өвчин үүсдэг бөгөөд энэ үед өндөр нягттай липопротейдын цусанд агуулагдах хэмжээ буурч, бага нягттай липопротеины хэмжээ өсдөг. Бид энэхүү судалгаагаар цусан дахь өөх-тосны хэмжээг бууруулах идэвхтэй шинэ нэгдлийг гарган авах зорилгоор хүнс болон уламжлалт анагаах ухаанд өргөн ашигладаг хар чинжүү буюу бивлэн (Piper longum)-ийн пиперин алкалоидоос пиперлонгуминины хүчлийг нийлэгжүүлэн гарган авч, өөх-тосны солилцоонд үйлчлэх үйлдлийг in vivo нөхцөлд туршилтын хулгана дээр судлав. Судалгааны дүнд шинээр нийлэгжүүлэн гарган авсан пиперлонгуминины хүчил нийт холестерин, триглицерид, бага нягттай липопротеины хэмжээг 4.93 мм/л, 1.15 мм/л, 1.11 мм/л хэмжээгээр тус тус бууруулж, их нягттай липопротеины хэмжээг 0.19 мм/л-ээс 0.26 мм/л болтол өсгөж байгаа нь цусан дахь өөх-тосны хэмжээг бууруулах өндөр идэвхтэй болох ба судас хатуурах өвчнөөс урьдчилан сэргийлэх бэлдмэл болгон ашиглах боломжтойг харуулж байна. Түлхүүр үг: Пиперин, Piper longum, холестерин, атеросклероз, нийлэгжүүлэлт

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The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet

Food & Function ◽

10.1039/d0fo00439a ◽

2020 ◽

Vol 11 (6) ◽

pp. 5024-5039 ◽

Cited By ~ 1

Author(s):

Yujun Liu ◽

Yuan Gao ◽

Fenglian Ma ◽

Mengying Sun ◽

Guangqing Mu ◽

...

Keyword(s):

Antioxidant Activity ◽

Lipid Metabolism ◽

Oral Administration ◽

Lactobacillus Plantarum ◽

High Fat Diet ◽

Intestinal Transit ◽

Obese Mice ◽

High Fat ◽

Ameliorative Effect ◽

Transit Tolerance

In our previous studies, Lactobacillus plantarum Y44 showed antioxidant activity and favorable gastric and intestinal transit tolerance.

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Sesamol intervention ameliorates obesity-associated metabolic disorders by regulating hepatic lipid metabolism in high-fat diet-induced obese mice

Food & Nutrition Research ◽

10.29219/fnr.v63.3637 ◽

2019 ◽

Vol 63 (0) ◽

Cited By ~ 2

Author(s):

Hong Qin ◽

Haiyan Xu ◽

Liang Yu ◽

Lina Yang ◽

Cui Lin ◽

...

Keyword(s):

Lipid Metabolism ◽

High Fat Diet ◽

Metabolic Disorders ◽

Obese Mice ◽

High Fat ◽

Hepatic Lipid Metabolism ◽

Hepatic Lipid

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The beneficial effects of Lactobacillus brevis FZU0713-fermented Laminaria japonica on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed a high-fat diet

Food & Function ◽

10.1039/d1fo00218j ◽

2021 ◽

Author(s):

Qing Zhang ◽

xiaoyun fan ◽

Ying-Jia Cao ◽

Ting-Ting Zheng ◽

Wenjian Cheng ◽

...

Keyword(s):

Lipid Metabolism ◽

Oral Administration ◽

Intestinal Microbiota ◽

High Fat Diet ◽

Laminaria Japonica ◽

Lactobacillus Brevis ◽

High Fat ◽

Beneficial Effects

This study aimed to investigate the beneficial effects of oral administration of Lactobacillus brevis FZU0713-fermented Laminaria japonica (FLJ) on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed a high-fat...

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Oral Administration of Latilactobacillus sakei ADM14 Improves Lipid Metabolism and Fecal Microbiota Profile Associated With Metabolic Dysfunction in a High-Fat Diet Mouse Model

Frontiers in Microbiology ◽

10.3389/fmicb.2021.746601 ◽

2021 ◽

Vol 12 ◽

Author(s):

Sung-Min Won ◽

Min Ju Seo ◽

Min Ju Kwon ◽

Kye Won Park ◽

Jung-Hoon Yoon

Keyword(s):

Lipid Metabolism ◽

Mouse Model ◽

Oral Administration ◽

High Fat Diet ◽

Body Weight Gain ◽

Fecal Microbiota ◽

Normal Diet ◽

Epididymal Adipose Tissue ◽

High Fat ◽

Tissue Mass

Effects of Latilactobacillus sakei ADM14 on changes in lipid metabolism and fecal microbiota composition were studied in high-fat diet (HFD) mouse model. The mice were divided into three groups: normal diet (ND), high-fat diet (HD), and HFD plus L. sakei ADM14 (HDA). Oral administration of L. sakei ADM14 daily for 10weeks decreased body weight gain, fat tissue mass, and liver weight in mice and reduced the size of histologically stained liver adipocytes. In addition, serum total cholesterol, triglycerides, and blood glucose decreased significantly. Latilactobacillus sakei ADM14 regulated the expression of genes related to lipid metabolism in epididymal adipose tissue and liver and induced changes in the composition of fecal microbiota, thereby improving energy harvests and changing metabolic disorder-related taxa. A significant decrease (p<0.05) in the Firmicutes to Bacteroidetes ratio was found in the HDA group compared to the HD group, particularly due to the difference in the relative abundance of the Bacteroidetes between the two groups over 10weeks. Differences in proportions of some taxa reported to have correlation with obesity were also found between HD and HDA groups. These results suggest that L. sakei ADM14 can have a positive effect on metabolic disorders such as obesity and fatty liver through effective regulation of host lipid metabolism and gut microbiota.

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