Identifying peripapillary radial capillary plexus alterations in Parkinson’s disease using optical coherence tomography angiography

AbstractTo evaluate the significance of motion artifacts in optical coherence tomography angiography (OCTA) images of patients with Parkinson’s disease (PD) and healthy controls. In this prospective, cross-sectional study subjects with medicated PD (ON) and healthy, age- and gender-matched volunteers were recruited. Participants underwent specific ophthalmological examinations, including OCTA. Angiograms of the superficial retinal capillary plexus were evaluated for the type and frequency of artifacts using a validated motion artifact score (MAS). A total of 30 PD patients (60 eyes), average disease duration of 9.61 ± 5.55 years, and 30 matched, healthy controls (60 eyes) were recruited. Twenty percent of all eyes had an eye disease, unknown to the participant, with a significant impact on OCTA results. After cleansing the dataset by excluding subjects with confounding ocular comorbidities 42 eyes of 28 PD patients and 53 eyes of 29 healthy controls were further evaluated. Overall MAS and all five subtypes of motion artifacts were comparable without significant differences between groups. OCTA can be used in treated PD patients (ON) without a significant increase in motion artifacts. Nevertheless, special attention should be paid to image quality during the acquisition of OCTA data, for which an experienced OCTA operator is useful.

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Evaluating Retinal and Choroidal Perfusion Changes after Isometric and Dynamic Activity Using Optical Coherence Tomography Angiography

Diagnostics ◽

10.3390/diagnostics11050808 ◽

2021 ◽

Vol 11 (5) ◽

pp. 808

Author(s):

Max Philipp Brinkmann ◽

Nikolas Xavier Kibele ◽

Michelle Prasuhn ◽

Vinodh Kakkassery ◽

Mario Damiano Toro ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Isometric Exercise ◽

Dynamic Exercise ◽

Exercise Heart Rate ◽

Optical Coherence ◽

Dynamic Activity ◽

Capillary Plexus ◽

Choroidal Perfusion

Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal perfusion state in vivo. This study aimed to evaluate the acute effects of isometric and dynamic exercise on retinal and choroidal sublayer perfusion using OCTA. A pilot study was conducted on young, healthy participants, each of whom performed a specific isometric exercise on the first day and a dynamic exercise the day after. At baseline and immediately after the exercise, heart rate (HR), mean arterial pressure (MAP), superficial capillary plexus perfusion (SCPP), deep capillary plexus perfusion (DCPP), choriocapillaris perfusion (CCP), Sattlers’s layer perfusion (SLP), and Haller’s layer perfusion (HLP) were recorded. A total of 34 eyes of 34 subjects with a mean age of 32.35 ± 7.87 years were included. HR as well as MAP increased significantly after both types of exercise. Both SCPP and DCPP did not show any significant alteration due to isometric or dynamic exercise. After performing dynamic exercise, CCP, SLP, as well as HLP significantly increased. Changes in MAP correlated significantly with changes in HLP after the dynamic activity. OCTA-based analysis in healthy adults following physical activity demonstrated a constant retinal perfusion, supporting the theory of autoregulatory mechanisms. Dynamic exercise, as opposed to isometric activity, significantly changed choroidal perfusion. OCTA imaging may represent a novel and sensitive tool to expand the diagnostic spectrum in the field of sports medicine.

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The role of quantitative deep capillary plexus in the pathogenesis of type 3 macular neovascularization: an optical coherence tomography angiography study

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05330-w ◽

2021 ◽

Author(s):

Marina Concilio ◽

Federica Fossataro ◽

Daniela Montorio ◽

Mariapaola Giordano ◽

Gilda Cennamo

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Early Stage ◽

Study Groups ◽

Control Group ◽

Main Role ◽

Optical Coherence ◽

Capillary Plexus ◽

Type 3

Abstract Purpose To quantitatively investigate the role of deep capillary plexus (DCP) in patients affected by type 3 macular neovascularization (MNV), compared to patients with reticular pseudodrusen (RPD) eyes and healthy controls, using optical coherence tomography angiography (OCTA). Methods In this prospective observational study, a total of seventy-eight eyes of 78 patients were included. Group 1 consisted of 40 eyes of 40 patients with stage 1 of type 3 MNV (22 males, 18 females, mean age 73.7, SD ± 6.60) and group 2 included 38 eyes of 38 patients with RPD (17 males, 21 females, mean age 73.2, SD ± 4.55). The control group included 40 eyes of 40 healthy subjects (20 males, 20 females, mean age 71.4, SD ± 6.36 years). We evaluated the retinal vessel density (VD) of superficial capillary plexus (SCP) and deep capillary plexus (DCP) using OCTA. Results Patients with diagnosis of type 3 MNV showed statistically lower values of VD in DCP with respect to controls and to RPD group (p < 0.001), while there were no statistical differences between RPD and control group in macular region. No significant differences in VD of SCP were detected among the three study groups. Conclusion OCTA provides a reproducible, non-invasive detailed quantitative analysis of retinal vascular features and changing in early-stage type 3 MNV patients, which allowed to shed the light on the main role of DCP ischemia in the development of type 3 MNV.

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Retinal microcirculation abnormalities in patients with systemic sclerosis: an explorative optical coherence tomography angiography study

Rheumatology ◽

10.1093/rheumatology/keab258 ◽

2021 ◽

Author(s):

Adriano Carnevali ◽

Giuseppe Giannaccare ◽

Valentina Gatti ◽

Caterina Battaglia ◽

Giorgio Randazzo ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Flow Index ◽

Digital Ulcers ◽

Optical Coherence ◽

Vascular Abnormalities ◽

Capillary Plexus ◽

Retinal Microcirculation ◽

Vascular Plexuses

Abstract Objectives To investigate subclinical and clinical abnormalities in retinal and choroidal vascular plexuses in patients with SSc by means of optical coherence tomography angiography (OCT-A). Methods A total of 20 consecutive SSc patients were recruited and compared with 20 healthy subjects. Quantitative analysis of vessel density (VD), choriocapillaris plexus flow index (CCP-FI) and choroidal vascularity index were performed on OCT-A images in the superficial capillary plexus (SCP), deep capillary plexus (DCP) and CCP for all patients. Images were further reviewed by two independent readers for the assessment of qualitative abnormalities, including tortuosity, rarefaction areas, megacapillaries and macular-foveal capillaries. Results The DCP-VD in the whole scan and in the perifoveal, superior, inferior, nasal and temporal regions was significantly lower in the SSc group. The CCP-FI was significantly higher in SSc patients. When comparing SSc patients with and without digital ulcers, significantly decreased SCP-VD was demonstrated in the whole, perifoveal, superior, inferior, temporal and nasal regions. No difference in any of the OCT-A parameters was observed when comparing patients with and without interstitial lung disease. Qualitative analysis of OCT-A revealed at least one abnormality in 95% of patients. Conclusion We showed the ability of OCT-A to disclose early ocular vascular abnormalities in patients with SSc. Our results may represent a hypothesis-generating basis for exploring the potential role of OCT-A in diagnosis, monitoring and prognosis stratification in SSc.

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Foveal avascular zone in oculocutaneous albinism

BMJ Case Reports ◽

10.1136/bcr-2020-240208 ◽

2021 ◽

Vol 14 (5) ◽

pp. e240208

Author(s):

Hana A Mansour ◽

Sami Uwaydat ◽

Muhamad H Yunis ◽

Ahmad M Mansour

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Oculocutaneous Albinism ◽

Foveal Avascular Zone ◽

Optical Coherence ◽

Retinal Capillary ◽

Avascular Zone ◽

Capillary Plexus ◽

Foveal Hypoplasia

Optical coherence tomography angiography imaging in two patients with oculocutaneous albinism, one with severe nystagmus, showed persistence of both the superficial and the deep retinal capillary plexus adding another vascular feature to the foveal hypoplasia.

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Inter-relationship between retinal and choroidal vasculatures using optical coherence tomography angiography in normal eyes

European Journal of Ophthalmology ◽

10.1177/1120672118816225 ◽

2018 ◽

Vol 30 (1) ◽

pp. 48-57 ◽

Cited By ~ 5

Author(s):

Jaeryung Oh ◽

Daniel Jinhag Baik ◽

Jaemoon Ahn

Keyword(s):

Optical Coherence Tomography ◽

Layer Thickness ◽

Optical Coherence Tomography Angiography ◽

Macular Thickness ◽

Vascular Density ◽

Inner Plexiform Layer ◽

Central Macular Thickness ◽

Optical Coherence ◽

Outer Retina ◽

Capillary Plexus

Purpose: To quantify vascular and structural macular variables in healthy eyes and to investigate correlations between these variables and age using optical coherence tomography angiography. Materials and methods: A total of 261 eyes of 261 subjects with normal fundus were included. Central macular thickness, ganglion cell layer to inner plexiform layer thickness, outer retina layer thickness, subfoveal choroidal thickness, and choroidal vascularity index were measured using optical coherence tomography. Foveal avascular zone area, vascular density, and flow void area were measured using optical coherence tomography angiography. Results: Vascular density in the superficial capillary plexus was correlated with central macular thickness, ganglion cell layer to inner plexiform layer thickness, and outer retina layer thickness ( P < 0.001, P = 0.004, and P < 0.001, respectively). Vascular density in the deep capillary plexus was correlated with central macular thickness and outer retina layer thickness ( P = 0.003 and P = 0.001, respectively). Vascular density of choriocapillaris was correlated with vascular density of superficial capillary plexus and deep capillary plexus ( P < 0.001 and P = 0.001, respectively). Conclusion: Vascular density of choriocapillaris varies with retinal vascular density rather than the structure of choroid using optical coherence tomography angiography. In contrast, retinal vascular density changes as the retinal structure. Our results provide more information about the relationship between retina and choroid.

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A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomography

Movement Disorders ◽

10.1002/mds.26411 ◽

2015 ◽

Vol 30 (12) ◽

pp. 1692-1695 ◽

Cited By ~ 12

Author(s):

Samantha Slotnick ◽

Yin Ding ◽

Sofya Glazman ◽

Mary Durbin ◽

Shahnaz Miri ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Optical Coherence Tomography ◽

Optical Coherence

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Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2 with Associated Subretinal Neovascular Membrane

Case Reports in Ophthalmological Medicine ◽

10.1155/2017/8186134 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4

Author(s):

Victor M. Villegas ◽

Jaclyn L. Kovach

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Subretinal Neovascularization ◽

Macular Telangiectasia ◽

Capillary Plexus ◽

Macular Telangiectasia Type 2 ◽

Subretinal Neovascular Membrane ◽

Choroidal Vasculature

Optical coherence tomography angiography (OCTA) is a recently established noninvasive technology for evaluation of the retinal and choroidal vasculature. The literature regarding the findings in macular telangiectasia type 2 (MacTel2) is scarce. We report the OCTA findings associated with a subject with MacTel2 and secondary subretinal neovascularization (SNV). The commercially available Cirrus 5000 with AngioPlex (Zeiss, Jena, Germany) was used, without any subsequent image modification or processing. Subretinal neovascularization was detectable with OCTA at the level of the outer retina and choriocapillaris. Microvascular abnormalities associated with MacTel2 were present mostly in the deep capillary plexus of the retina temporally.

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