The role of pulse oximetry in the early assessment of acute pancreatitis

Background: Acute pancreatitis is one of the most commonly encountered clinical entities in surgical practice and controversy still exists regarding the clinical features of acute pancreatitis. An early diagnosis, however, is regarded as mandatory for successful treatment. Over the years many Authors have proposed different scoring systems for the early assessment of the clinical evolution of acute pancreatitis. The most widely used scoring systems are often cumbersome and difficult to use in clinical practice because of their multi factorial nature. Thus, a number of unifactorial prognostic indices have been employed in routine hospital practice, such as C-reactive protein (CRP), serum amylase and serum lipase. These serum enzymes are easy to obtain in normal clinical practice and many authors consider them as reliable as multi factorial scoring systems.Methods: A hospital based observational prospective study was done with 30 patients to measure C reactive protein levels in patients of acute pancreatitis and evaluate if CRP levels predict the severity of pancreatitis.Results: In cases where CRP was raised >100 mg/dl on day 7 and beyond showed either a complication or increased duration of stay and delayed recovery. This correspondence of CRP with the clinical outcome co related well with other parameters like blood counts, serum lipase and amylase levels too.Conclusions: Hence, CRP can be a very useful uni factorial tool in assessing and thereby predicting the outcome in a case of pancreatitis.

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The Role of Nonenhanced Magnetic Resonance Imaging in the Early Assessment of Acute Pancreatitis

The American Journal of Gastroenterology ◽

10.1111/j.1572-0241.2007.01164.x ◽

2007 ◽

Vol 102 (5) ◽

pp. 997-1004 ◽

Cited By ~ 61

Author(s):

Davor Štimac ◽

Damir Miletić ◽

Mladen Radić ◽

Irena Krznarić ◽

Marzena Mazur-Grbac ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Acute Pancreatitis ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Early Assessment

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Role of Clinical, Biochemical, and Imaging Parameters in predicting the Severity of Acute Pancreatitis

Euroasian Journal of Hepato-Gastroenterology ◽

10.5005/jp-journals-10018-1202 ◽

2017 ◽

Vol 7 (1) ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Dina Zerem ◽

Omar Zerema ◽

Enver Zerem

Keyword(s):

Acute Pancreatitis ◽

Leukocyte Count ◽

Apache Ii ◽

Close Monitoring ◽

Early Assessment ◽

Diagnostic Parameters ◽

Factors Associated ◽

Imaging Parameters ◽

Glasgow Score

ABSTRACT Aim The assessment of the severity of acute pancreatitis (AP) is important for proper management of the disease and for its prognosis. The aim was to correlate clinical, biochemical, and imaging diagnostic parameters and evaluate their prognostic values in the early assessment of severity of AP. Materials and methods We prospectively studied 128 consecutive patients with AP. The predictors were clinical, biochemical, and imaging diagnostic parameters. The outcome measure was the occurrence of complications. Abdominal sonogram, contrast-enhanced computer tomography, and pancreatitis-specific clinical and laboratory findings were done. Results According to the Atlanta classification, 84 patients (65.6%) had mild and 44 (34.4%) had severe AP. The severity markers were significantly different between the mild and the severe groups (p < 0.001). Leukocyte count, serum albumin level, C-reactive protein (CRP), Ranson, acute physiology and chronic health evaluation II (APACHE II), and Glasgow score were the factors associated with radiological severity grade. Leukocyte count, CRP, Ranson score, APACHE II, and Glasgow score were the factors associated with the number and appearance of acute fluid collections (AFCs). A significant association was found between the number of AFCs and the occurrence of complications [odds ratio 4.4; 95% confidence interval 2.5–7.6]. Hospital stay was significantly longer in the group with severe disease as compared with the group with mild disease (p < 0.001). Conclusion Clinical, biochemical, and imaging diagnostic parameters are related to the clinical course of AP and they can predict its severity. This allows us to determine the severity of the disease and to target the patients with high scores for close monitoring and more aggressive intervention. How to cite this article Zerem D, Zerem O, Zerem E. Role of Clinical, Biochemical, and Imaging Parameters in predicting the Severity of Acute Pancreatitis. Euroasian J Hepato-Gastroenterol 2017;7(1):1-5.

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Role of Biomarkers in Diagnosis and Prognostic Evaluation of Acute Pancreatitis

Journal of Biomarkers ◽

10.1155/2015/519534 ◽

2015 ◽

Vol 2015 ◽

pp. 1-13 ◽

Cited By ~ 26

Author(s):

Susanta Meher ◽

Tushar Subhadarshan Mishra ◽

Prakash Kumar Sasmal ◽

Satyajit Rath ◽

Rakesh Sharma ◽

...

Keyword(s):

Acute Pancreatitis ◽

Biochemical Markers ◽

Necrotizing Pancreatitis ◽

Pancreatic Tissue ◽

Pancreatic Acinar Cell ◽

Early Assessment ◽

Prognostic Evaluation ◽

Reactive Protein ◽

Life Threatening

Acute pancreatitis is a potentially life threatening disease. The spectrum of severity of the illness ranges from mild self-limiting disease to a highly fatal severe necrotizing pancreatitis. Despite intensive research and improved patient care, overall mortality still remains high, reaching up to 30–40% in cases with infected pancreatic necrosis. Although little is known about the exact pathogenesis, it has been widely accepted that premature activation of digestive enzymes within the pancreatic acinar cell is the trigger that leads to autodigestion of pancreatic tissue which is followed by infiltration and activation of leukocytes. Extensive research has been done over the past few decades regarding their role in diagnosis and prognostic evaluation of severe acute pancreatitis. Although many standalone biochemical markers have been studied for early assessment of severity, C-reactive protein still remains the most frequently used along with Interleukin-6. In this review we have discussed briefly the pathogenesis and the role of different biochemical markers in the diagnosis and severity evaluation in acute pancreatitis.

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