scholarly journals Correlation between umbilical cord blood lipid profile and neonatal birth weight

2013 ◽  
Vol 88 (6) ◽  
pp. 521-525 ◽  
Author(s):  
Seyyed Mohammad Hassan Aletayeb ◽  
Masoud Dehdashtian ◽  
Majid Aminzadeh ◽  
Abdul-Rahman Emami Moghaddam ◽  
Mazyar Mortazavi ◽  
...  
2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Asadollah Kermani ◽  
Kokab Namakin ◽  
Gholam Reza Sharifzadeh ◽  
Gholam Reza Faal

2015 ◽  
Vol 4 (75) ◽  
pp. 13011-13015 ◽  
Author(s):  
Sirajuddin Nazeer ◽  
Nirmaladevi K ◽  
Mythili B ◽  
Saravanan B ◽  
Thangavel A

2020 ◽  
Vol 30 (3) ◽  
Author(s):  
Asadollah Kermani ◽  
Kokab Namakin ◽  
Gholam Reza Sharifzadeh ◽  
Gholam Reza Faal

Background: Coronary heart diseases (CAD) and their risk factors are among the major causes of death in Iran. Since these risk factors begin to develop early in life, it is vital to diagnose those newborns at high risk of CAD. Objectives: The present study investigated the umbilical cord blood lipid profile of term and preterm neonates. Methods: In this cross-sectional study, the lipid profiles of 292 neonates, of which 276 were term and 16 preterm, were examined at a teaching hospital. Results: The lipid profile results of total cholesterol, triglycerides, high density lipoprotein, and low density lipoprotein were 69.8, 34.9, 23.6, and 31.5 in term neonates and 80.5, 25.5, 25.1, and 38 in preterm neonates, respectively. Conclusions: According to the current paper, the lipid profiles of eastern Iranian neonates were similar to those reported in global studies. Moreover, except for triglycerides in the female neonates, lipid profiles were significantly higher among the male neonates.


2020 ◽  
Author(s):  
Francisco Algaba-Chueca ◽  
Elsa Maymó-Masip ◽  
Mónica Ballesteros ◽  
Albert Guarque ◽  
Olga Freixes ◽  
...  

Abstract Background Abnormal lipid metabolism is observed in gestational diabetes mellitus (GDM) and in neonates with abnormal fetal growth, however, how these alterations specifically affect the umbilical cord blood lipoprotein profile is not well understood. Objective To assess the impact of GDM on the cord blood lipoprotein profile across birth-weight categories by using Advanced Lipoprotein Testing. Methods observational study involving 74 control and 62 GDM pregnant women and their offspring. Newborns were classified according to birth-weight as small (n = 39), adequate (n = 50) or large (n = 49) for gestational age (SGA, AGA and LGA, respectively). Two-dimensional diffusion-ordered 1H-NMR spectroscopy was used to profile umbilical cord serum lipoproteins. One hundred and three children were available in a two years follow-up study to evaluate associations between cord blood lipid profile and obesity. Results Baseline characteristics of the two groups were similar except for gestational weight gain. The size, lipid content, number and concentration of particles within their subclasses were similar between offspring born to GDM and control mothers. Using two-way analysis of variance, we observed an interaction between GDM and birth-weight categories for IDL-cholesterol content and IDL- and LDL-triglyceride content, and the number of medium VLDL and LDL particles, specifically in AGA neonates. Small LDL particles were independently associated with offspring obesity at two years. Conclusions In this selected cohort, GDM disturbs triglyceride and cholesterol lipoprotein content across birth-weight categories, and AGA neonates born to GDM mothers display a profile more similar to adults with dyslipidemia and atherosclerosis than to those born to mothers with normal glucose tolerance.


2020 ◽  
Vol 98 (10) ◽  
Author(s):  
Kiah M Gourley ◽  
Joel M DeRouchey ◽  
Mike D Tokach ◽  
Steve S Dritz ◽  
Robert D Goodband ◽  
...  

Abstract A total of 656 pigs (623 live-born and 33 stillborn) from 43 sows were used to evaluate hematological criteria at birth and their association with piglet survival. At birth of each piglet, birth time and order within the litter, weight, umbilical cord status (intact or ruptured) and whether the pig was live-born or stillborn were recorded. A 200µL sample of blood from the umbilical cord was collected and immediately analyzed for concentrations of glucose, oxygen partial pressure (pO2), carbon dioxide partial pressure (pCO2), pH, base excess (BE), bicarbonate (HCO3), saturated oxygen (sO2), total carbon dioxide (TCO2), sodium, potassium, ionized calcium (iCa), hematocrit (Hct), and hemoglobin (Hb) on a hand held iStat portable clinical analyzer (iStat Alinity, Abbott Point of Care Inc., Princeton, NJ). Piglets were categorized into quartiles based on birth order and cumulative birth interval (CumBI). Live-born pigs had higher (P < 0.01) umbilical cord blood pH, HCO3, BE, sO2, TCO2, and birth weight compared with stillborn pigs, but lower (P < 0.01) pCO2, K, iCa, and glucose compared with stillborn pigs. Pigs with intact umbilical cords at birth were associated with higher (P < 0.01) blood pH, HCO3, BE, and TCO2 compared with piglets born with a ruptured umbilical cord. Pigs with intact umbilical cords were associated with lower (P < 0.01) Hct and Hb concentrations and born earlier (P < 0.01) in the birth order compared with pigs born with a ruptured umbilical cord. Pigs that did not survive to weaning had lower (P < 0.01) umbilical cord blood pH, HCO3, BE, sO2, TCO2, Na, glucose, and birth weight, and 24 hr weight compared with pigs alive at weaning. Pigs born in the first quartile for CumBI had higher (P <0.05) pH compared with pigs in the other three quartiles. Umbilical cord blood HCO3, BE, and TCO2 decreased (P <0.05) with each change in CumBI quartile from first to last. Blood glucose was lowest (P <0.05) in pigs born before 44 min and highest in pigs born after 164 min. Umbilical cord blood pH, HCO3, BE, TCO2, Na, glucose, Hct, and Hb were positively associated (P <0.001) with colostrum intake, indicating increased blood values resulted in higher colostrum intake. Although a pig may be live-born, their survival to 24 hr and to weaning is reduced when blood pH, HCO3, BE, and sO2 are lower reiterating the importance of management practices that can reduce the birth interval between pigs and the number of pigs experiencing moderate to severe hypoxia.


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