Mycobacterium tuberculosis surface protein Rv0227c contains high activity binding peptides which inhibit cell invasion

Peptides ◽  
2012 ◽  
Vol 38 (2) ◽  
pp. 208-216 ◽  
Author(s):  
Diana Marcela Rodríguez ◽  
Marisol Ocampo ◽  
Hernando Curtidor ◽  
Magnolia Vanegas ◽  
Manuel Elkin Patarroyo ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
High Activity ◽  
Cell Invasion ◽  
Surface Protein ◽  
Binding Peptides

Mycobacterium tuberculosis PE9 protein has high activity binding peptides which inhibit target cell invasion

2016 ◽  
Vol 86 ◽  
pp. 646-655 ◽  
Author(s):  
Diana P. Díaz ◽  
Marisol Ocampo ◽  
Laura Pabón ◽  
Chonny Herrera ◽  
Manuel A. Patarroyo ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
High Activity ◽  
Cell Invasion ◽  
Target Cell ◽  
Binding Peptides

Identifying and characterising PPE7 (Rv0354c) high activity binding peptides and their role in inhibiting cell invasion

2017 ◽  
Vol 430 (1-2) ◽  
pp. 149-160 ◽  
Author(s):  
Diana P. Díaz ◽  
Marisol Ocampo ◽  
Yahson Varela ◽  
Hernando Curtidor ◽  
Manuel A. Patarroyo ◽  
...  
Keyword(s):  
High Activity ◽  
Cell Invasion ◽  
Binding Peptides

scholarly journals The role of Mycobacterium tuberculosis Rv3166c protein-derived high-activity binding peptides in inhibiting invasion of human cell lines

2012 ◽  
Vol 25 (5) ◽  
pp. 235-242 ◽  
Author(s):  
M. Ocampo ◽  
D. Aristizabal-Ramirez ◽  
D. M. Rodriguez ◽  
M. Munoz ◽  
H. Curtidor ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
High Activity ◽  
Cell Lines ◽  
Human Cell ◽  
Human Cell Lines ◽  
Binding Peptides

scholarly journals In Vitro Antimycobacterial Activities of 2′-Monosubstituted Isonicotinohydrazides and Their Cyanoborane Adducts

2002 ◽  
Vol 46 (2) ◽  
pp. 294-299 ◽  
Author(s):  
Rosanna Maccari ◽  
Rosaria Ottanà ◽  
Francesca Monforte ◽  
Maria Gabriella Vigorita
Keyword(s):  
Mycobacterium Tuberculosis ◽  
High Activity ◽  
Culture Medium ◽  
Antimycobacterial Activity ◽  
Drug Resistant ◽  
Good Activity ◽  
Sodium Cyanoborohydride ◽  
Low Cytotoxicity ◽  
Safety Indices

ABSTRACT As a result of our search for new isoniazid derivatives with extended spectra of activity, we evaluated the in vitro antimycobacterial activities of isonicotinohydrazides (compounds 2) and their cyanoborane adducts (compounds 3), both obtained by the reaction of isonicotinoylhydrazones (compounds 1) with sodium cyanoborohydride. Most of the tested compounds displayed moderate to high activity against Mycobacterium tuberculosis H37Rv, with MICs ranging from 0.2 to 12.5 μg/ml. In particular, some hydrazides showed activity similar to that of rifampin (MIC = 0.2 μg/ml) and rather low cytotoxicity, so that they were generally shown to possess high safety indices. In contrast, the coordination to a cyanoborane (BH2CN) group (compounds 3) in general brought about a decrease in antimycobacterial activity, while cytotoxicity increased. Interestingly, selected compounds 1 to 3, mostly hydrazides (compounds 2), were effective in killing M. tuberculosis growing within macrophages at concentrations in culture medium which were much lower than the corresponding MICs. These compounds also displayed good activity against drug-resistant M. tuberculosis strains.

scholarly journals A 21-kDa surface protein of Mycobacterium leprae binds peripheral nerve laminin-2 and mediates Schwann cell invasion

1999 ◽  
Vol 96 (17) ◽  
pp. 9857-9862 ◽  
Author(s):  
Y. Shimoji ◽  
V. Ng ◽  
K. Matsumura ◽  
V. A. Fischetti ◽  
A. Rambukkana
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerve ◽  
Cell Invasion ◽  
Surface Protein ◽  
Mycobacterium Leprae

Conserved High Activity Binding Peptides are Involved in Adhesion of Two Detergent-Resistant Membrane-Associated Merozoite Proteins to Red Blood Cells during Invasion

2010 ◽  
Vol 53 (10) ◽  
pp. 3907-3918 ◽  
Author(s):  
Ana Zuleima Obando-Martinez ◽  
Hernando Curtidor ◽  
Gabriela Arévalo-Pinzón ◽  
Magnolia Vanegas ◽  
Carolina Vizcaino ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
High Activity ◽  
Blood Cells ◽  
Binding Peptides ◽  
Detergent Resistant Membrane

scholarly journals Characterization of the Mycobacterium tuberculosis erp gene encoding a potential cell surface protein with repetitive structures

Microbiology ◽  
1995 ◽  
Vol 141 (9) ◽  
pp. 2123-2130 ◽  
Author(s):  
F.-X. Berthet ◽  
J. Rauzier ◽  
E. M. Lim ◽  
W. Philipp ◽  
B. Gicquel ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Cell Surface ◽  
Surface Protein ◽  
Cell Surface Protein ◽  
Gene Encoding

scholarly journals Rh1 high activity binding peptides inhibit high percentages of Plasmodium falciparum FVO strain invasion

Vaccine ◽  
2013 ◽  
Vol 31 (14) ◽  
pp. 1830-1837 ◽  
Author(s):  
Gabriela Arévalo-Pinzón ◽  
Hernando Curtidor ◽  
Marina Muñoz ◽  
Diana Suarez ◽  
Manuel A. Patarroyo ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
High Activity ◽  
Binding Peptides
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