Effect of rosiglitazone and nateglinide on serum glucose and lipid profile alone or in combination with the biguanide metformin in diabetic rats

2006 ◽  
Vol 53 (1) ◽  
pp. 69-74 ◽  
Author(s):  
S ELBATRAN ◽  
O ABDELSALAM ◽  
S NOFAL ◽  
A BAIUOMY
Keyword(s):  
Lipid Profile ◽  
Serum Glucose ◽  
Diabetic Rats

scholarly journals The Effects of the Synthetic Antioxidant, Tempol, on Serum Glucose and Lipid Profile of Diabetic and Non-Diabetic Rats

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Siamak Shahidi ◽  
Zahra Jabbarpour ◽  
Masoud Saidijam ◽  
Rasoul Esmaeili ◽  
Alireza Komaki ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Synthetic Antioxidant

scholarly journals Raw Camel Milk Properties on Alloxan-Induced Diabetic Wistar Rats

2017 ◽  
Vol 24 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Nasr-Eddine Kebir ◽  
Ahmed Aichouni ◽  
Touria Zahzeh
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Normal Diet ◽  
Camel Milk ◽  
Antidiabetic Activity ◽  
Albino Rats

AbstractBackground and aims: Diabetes is one of the most frequent and serious chronic diseases in humans all over the world. The aim of our study was to evaluate the antidiabetic activity of camel milk on serum glucose and lipid profile of alloxan-induced diabetic rats.Materials and methods: Diabetes was induced in Wistar albino rats by intraperitoneal injection of alloxan (120 mg/kg BW once). Albino rats each weighing 180-230g were divided into 3 equal groups (n=10) as following: G1 - normal rats fed on normal diet, G2 - diabetic rats fed on normal diet, and G3 - diabetic rats were fed with raw camel milk. Fasting blood glucose was measured on days 0, 1, 7, 14, 21 and 30 while lipid profile was assessed at day 30.Results: After four weeks of feeding, data indicated a significant decrease (p<0.05) of mean blood glucose in G3 group (133.80±3.22 mg/dL) as compared with G2 diabetic rats (199.6± 7.33 mg/dL). Data also revealed significant lower levels (p<0.05) of triglycerides, total cholesterol, LDL and VLDL and higher level of HDL cholesterol in diabetic rats treated with camel milk as compared with diabetic rats fed a normal diet.Conclusion: Raw camel milk improved the glycemic and lipid profile in diabetic rats. These findings indicate that raw camel milk may have potential benefits in the treatment of diabetes. Future studies will be needed to establish its safety and mechanism of action.

Effect of Hexagonal Water on Serum Glucose Level and Lipid Profile in Streptozotocin-Induced Diabetic Rats

2015 ◽  
Vol 6 (5) ◽  
Author(s):  
Alireza Kheirollah ◽  
Ahmad Maghuli ◽  
Payam Dalvand ◽  
Marzieh Mohaghegh ◽  
Tara Barat ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Glucose Level ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Serum Glucose Level

scholarly journals Antidiabetic Potential of Stem Bark Extract of Enantia chlorantha and Lack of Modulation of Its Therapeutic Efficacy in Diabetic Rats Co-Administered with Lisinopril

2021 ◽  
Vol 68 (1) ◽  
pp. 127-127
Author(s):  
Latifat Bolanle Ibrahim ◽  
Patience Funmilayo Idowu ◽  
Opemipo Adekanye Moses ◽  
Mutiu Adewunmi Alabi ◽  
Emmanuel Oladipo Ajani
Keyword(s):  
Lipid Profile ◽  
Stem Bark ◽  
Inhibitory Effect ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Bark Extract ◽  
Therapeutic Implications ◽  
Glucose Levels

This study validates the antidiabetic efficacy of Enantia chlorantha stem bark and the possible therapeutic implications of the co-administration of lisinopril and E. chlorantha in type 2 diabetic rats. E. chlorantha stem bark was extracted by cold maceration. The inhibitory effect of the plant on carbohydrate metabolizing enzymes and its antioxidative potentials were assessed in vitro. The extract exhibited α-amylase and α-glucosidase inhibitory activities and also showed antioxidative properties in vitro. Administration of the extract normalized fasting hyperglycemia in vivo by showing 47.24% reduction in blood glucose levels relative to untreated diabetic rats. Co-administration of E. chlorantha and lisinopril restored serum glucose and serum lipid profile levels. E. chlorantha stem bark displayed antidiabetic potentials as compared with a standard antidiabetic drug (metformin). The study also showed that the plant contained some bioactive compounds which we hypothesize might be responsible for the observed activities. Co-administration of the plant with lisinopril conferred no significant therapeutic advantage on the serum glucose level and lipid profile.

Flavonoids Extracted from Asteriscus graveolens Improve Glucose Metabo-lism and Lipid Profile in Diabetic Rats

2020 ◽  
Vol 20 ◽  
Author(s):  
Fadwa El-ouady ◽  
Fatima Bachir ◽  
Mohamed Eddouks
Keyword(s):  
Glucose Tolerance ◽  
Lipid Profile ◽  
Histopathological Examination ◽  
Oral Treatment ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Traditional Use ◽  
Soxhlet Apparatus

Aim: This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of Asteriscus graveolens. Background: Asteriscus graveolens (Asteraceae) is a medicinal plant widely used by the Moroccan population to treat various diseases including diabetes. Objective: This work aimed to assess the capacity of flavonoids extracted from Asteriscus graveolens (FEE) to improve diabetes mellitus and dyslipidemia in normal and STZ-induced diabetic rats. Methods: Flavonoids were extracted from A. graveolens using the Soxhlet apparatus and using different organic solvents. Normal and streptozotocin-induced diabetic rats were treated orally by the extract of A. graveolens at a dose of 10 mg/kg. The oral treatment during 15 days was used to evaluate the effect of the flavonoids extracted from A. graveolens on blood glucose level and lipid profile in normal and diabetic rats. The oral glucose tolerance test as well as the analysis of histopathological examination of liver was performed. The antioxidant activity of FEE was also assessed by the method of trapping of free radical 2,2-diphenyl-1 picrylhydrazyl (DPPH), in order to estimate the mechanisms of action involved by FEE to improve hyperglycemia and lipid profile in normal and diabetic rats. Results: FEE reduced serum glucose concentrations in both normal and diabetic rats and exhibited in the last group lowering total cholesterol and triglycerides effects as well as improvement of the HDL-cholesterol serum level. In addition, a remarkable influence on glucose tolerance was also noticed after FEE treatment. Moreover, FEE was able to improve histopathological status of liver and possess a potential antioxidant effect in vitro. Conclusion: In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of FEE in rats supporting then its traditional use for the management of diabetes.

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