Effect of oral administration of aqueous leaf extract of <i>Momordica charantia</i> (bitter melon) on serum glucose, and lipid profile in alloxan-induced diabetic rats

The blood glucose, total serum cholesterol, High Density Lipoprotein (HDL) and Triglyceride (TRIG) levels of all rats in each group were determined before induction, post-induction with alloxan and post treatment with various concentrations of extract and standard drug. The alloxan diabetic rats treated with gliberclamide and aqueous leaf extract of Annona muricata showed average means of body weights as; (235.73±3.14a, 263.94±2.25a and 236.5±1.74a) respectively after 4 weeks of treatment. The Glucose level revealed; 168.43±5.06e, 65.29±4.57f and 57.86±3.93e respectively. Lipid profile raised significantly post exposure of diabetic rats to both standard drug and extract after 4 weeks of treatment. Therefore, A. muricata compared favorably with the standard drug in the context of diabetes management.

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Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530318666181113124727 ◽

2019 ◽

Vol 19 (4) ◽

pp. 503-510 ◽

Cited By ~ 2

Author(s):

Mohamed Eddouks ◽

Farid Khallouki ◽

Robert W. Owen ◽

Morad Hebi ◽

Remy Burcelin

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Oral Administration ◽

Lipid Profile ◽

Plasma Cholesterol ◽

Diabetic Rats ◽

Lipid Lowering ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Lowering Activity

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A). Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight. Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001). Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

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Effect of rosiglitazone and nateglinide on serum glucose and lipid profile alone or in combination with the biguanide metformin in diabetic rats

Pharmacological Research ◽

10.1016/j.phrs.2005.08.008 ◽

2006 ◽

Vol 53 (1) ◽

pp. 69-74 ◽

Cited By ~ 15

Author(s):

S ELBATRAN ◽

O ABDELSALAM ◽

S NOFAL ◽

A BAIUOMY

Keyword(s):

Lipid Profile ◽

Serum Glucose ◽

Diabetic Rats

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Nephroprotective Property of C. chayamansa Aqueous Leaf Extract in Diabetic Rats

European Journal of Medicinal Plants ◽

10.9734/ejmp/2020/v31i1230306 ◽

2020 ◽

pp. 72-84

Author(s):

Jonathan Dingkwoet Dabak ◽

Rose Titus Kuyambana ◽

Titilayo Omolara Johnson ◽

Jonathan Latrwang Dabal

Keyword(s):

Uric Acid ◽

Leaf Extract ◽

Diabetic Rats ◽

Histopathological Study ◽

Standard Drug ◽

Aqueous Leaf Extract ◽

Group 5 ◽

Group 2 ◽

High Doses ◽

Test Control

Aim: To evaluate the nephroprotective property of Cnidoscolus chayamansa aqueous leaf extract in diabetic rats. Study Design: Rats were randomly divided into five groups with group 1 as the normal control. Diabetic was induced in groups 2-4. Group 2 was used as the test control while groups 3 and 4 were treated with different concentrations of the leaf extract; group 5 was treated with the standard drug, glipizide. Place and Duration of Study: Departments of Biochemistry and Anatomy, University of Jos, Nigeria, between August to November, 2019. Methodology: Fourty (40) male albino Wistar rats were grouped into five groups. The rats were treated for fourteen days and then sacrificed by decapitation after anaesthesia. Blood was collected for biochemical parameters; kidney was excised and stored in formaldehyde until required for histopathological study. Serum urea, creatinine, uric acid, sodium, potassium, chloride and bicarbonate were determined using appropriate methods. Results: The test control had a significant (P < .05) decrease in the concentrations of Na+, Cl- and HCO3- ions; significant (P < .05) increases in serum K+ ion, urea, uric acid and creatinine. Treatments of the test groups with the different doses of the leaf extract and the standard drug increased the concentration of Na+ ion which was not significantly (P < .05) different from the test control. On the other hand, the concentration of Cl- and HCO- ions were significantly (P < .05) increased; the concentrations of K+, urea, uric acid and creatinine were significantly (P < .05) decreased. The histochemistry of the kidneys revealed that the injury brought about under diabetic condition was ameliorated with the treatments with the low and high doses of the leaf extract, and the standard drug. Conclusion: The results show that the aqueous leaf extract has nephroprotective property.

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