Targeting the Brain Lesions Using Peptides: A Review Focused on the Possibility of Targeted Drug Delivery to Multiple Sclerosis Lesions

2021 ◽  
pp. 105441
Author(s):  
Atefeh Rayatpour ◽  
Mohammad Javan
Keyword(s):  
Multiple Sclerosis ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Brain Lesions ◽  
Targeted Drug ◽  
The Brain

Recent Advances in Targeted Drug Delivery Approaches using Lipidic and Polymeric Nanocarriers for the management of Alzheimer’s Disease

2021 ◽  
Vol 27 ◽  
Author(s):  
Dhara Lakdawala ◽  
Md Abdur Rashid ◽  
Farhan Jalees Ahmad
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Brain Barrier ◽  
Polymeric Nanocarriers ◽  
Blood Brain ◽  
Targeted Drug ◽  
The Brain

: Drug delivery to the brain has remained a significant challenge in treating neurodegenerative disorders such as Alzheimer's disease due to the presence of the blood-brain barrier, which primarily obstructs the access of drugs and biomolecules into the brain. Several methods to overcome the blood-brain barrier have been employed, such as chemical disruption, surgical intervention, focused ultrasound, intranasal delivery and using nanocarriers. Nanocarrier systems remain the method of choice and have shown promising results over the past decade to achieve better drug targeting. Polymeric nanocarriers and lipidic nanoparticles act as a carrier system providing better encapsulation of drugs, site-specific delivery, increased bioavailability and sustained release of drugs. The surface modifications and functionalization of these nanocarrier systems have greatly facilitated targeted drug delivery. The safety and efficacy of these nanocarrier systems have been ascertained by several in vitro and in vivo models. In the present review, we have elaborated on recent developments of nanoparticles as a drug delivery system for Alzheimer's disease, explicitly focusing on polymeric and lipidic nanoparticles.

scholarly journals Macrophages with cellular backpacks for targeted drug delivery to the brain

Biomaterials ◽  
2017 ◽  
Vol 140 ◽  
pp. 79-87 ◽  
Author(s):  
Natalia L. Klyachko ◽  
Roberta Polak ◽  
Matthew J. Haney ◽  
Yuling Zhao ◽  
Reginaldo J. Gomes Neto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
The Brain

scholarly journals Targeted drug delivery to the brain using magnetic nanoparticles

2015 ◽  
Vol 6 (10) ◽  
pp. 1145-1155 ◽  
Author(s):  
Louiza Bohn Thomsen ◽  
Maj Schneider Thomsen ◽  
Torben Moos
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
The Brain

scholarly journals Chitosan-Based Nanocarriers for Nose to Brain Delivery

2019 ◽  
Vol 9 (11) ◽  
pp. 2219 ◽  
Author(s):  
Blessing Atim Aderibigbe ◽  
Tobeka Naki
Keyword(s):  
Drug Delivery ◽  
Nasal Mucosa ◽  
Targeted Drug Delivery ◽  
Drug Uptake ◽  
Brain Diseases ◽  
In Vivo Studies ◽  
Brain Targeting ◽  
Prolonged Contact ◽  
Targeted Drug ◽  
The Brain

In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain. These drugs do not exhibit targeted drug delivery mechanisms, resulting in a high concentration of the drugs in vital organs leading to drug toxicity. Chitosan (CS) is a natural-based polymer. It has unique properties such as good biodegradability, biocompatibility, mucoadhesive properties, and it has been approved for biomedical applications. It has been used to develop nanocarriers for brain targeting via intranasal administration. Nanocarriers such as nanoparticles, in situ gels, nanoemulsions, and liposomes have been developed. In vitro and in vivo studies revealed that these nanocarriers exhibited enhanced drug uptake to the brain with reduced side effects resulting from the prolonged contact time of the nanocarriers with the nasal mucosa, the surface charge of the nanocarriers, the nano size of the nanocarriers, and their capability to stretch the tight junctions within the nasal mucosa. The aforementioned unique properties make chitosan a potential material for the development of nanocarriers for targeted drug delivery to the brain. This review will focus on chitosan-based carriers for brain targeting.

Targeted drug delivery to the brain via phosphonate derivatives

1998 ◽  
Vol 166 (1) ◽  
pp. 15-26 ◽  
Author(s):  
Gabor Somogyi ◽  
Sinji Nishitani ◽  
Daishuke Nomi ◽  
Peter Buchwald ◽  
Laszlo Prokai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
The Brain
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