Pharmacological assay of Cordia verbenacea V: oral and topical anti-inflammatory activity, analgesic effect and fetus toxicity of a crude leaf extract

Phytomedicine ◽  
2005 ◽  
Vol 12 (5) ◽  
pp. 338-344 ◽  
Author(s):  
J.A.A. Sertié ◽  
R.G. Woisky ◽  
G. Wiezel ◽  
M. Rodrigues
Keyword(s):  
Analgesic Effect ◽  
Leaf Extract ◽  
Inflammatory Activity ◽  
Crude Leaf Extract ◽  
Anti Inflammatory

scholarly journals Analgesic and Anti-Inflammatory Activity of Total Crude Leaf Extract of <i>Phytolacca dodecandra</i> in Wistar Albino Rats

2019 ◽  
Vol 10 (03) ◽  
pp. 259-271
Author(s):  
Loyce Nakalembe ◽  
Josephine N. Kasolo ◽  
Edward Nyatia ◽  
Aloysius Lubega ◽  
Godfrey S. Bbosa
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Phytolacca Dodecandra ◽  
Crude Leaf Extract ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

scholarly journals Analgesic and anti-Inflammatory activity of Tradescantia fluminensis leaves extract

2017 ◽  
Vol 6 (1) ◽  
pp. 34-37
Author(s):  
Wilson Rwai Waweru ◽  
◽  
Lawrence Obado Osuwat ◽  
Connie Wambui Mureithi ◽  
◽  
...  
Keyword(s):  
Leaf Extract ◽  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Control Group ◽  
Albino Rats ◽  
Crude Leaf Extract ◽  
Tradescantia Fluminensis ◽  
Anti Inflammatory ◽  
Analgesic Activities ◽  
Wistar Albino Rats

Objective: The present study sought to evaluate the anti-inflammatory and analgesic activities of ethanolic extract from Tradescantia fluminensis leaves. Methods: The crude leaf extract of T. fluminensis was investigated for anti-inflammatory and analgesic activities in Wistar Albino rats and mice respectively. The anti-inflammatory activity was investigated using egg albumin induced oedema model while acetic acid and formalin-induced paw licking models were used to evaluate the analgesic activity. Results: The extract showed a significant (P<0.05) dose-dependent inhibition of inflammation and pain compared to the control group. Conclusion: The leaf extract possesses anti-inflammatory and analgesic activities. The activities could be attributed to phytochemicals present in the plant.

Anti-inflammatory activity of leaf extract and fractions of Bursera simaruba (L.) Sarg (Burseraceae)

2004 ◽  
Vol 92 (1) ◽  
pp. 129-133 ◽  
Author(s):  
B. Noguera ◽  
E. Dı́az ◽  
M.V. Garcı́a ◽  
A.San Feliciano ◽  
J.L. López-Perez ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Bursera Simaruba ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Activity of Populus deltoides Leaf Extract via Modulating NF-κB and p38/JNK Pathways

2018 ◽  
Vol 19 (12) ◽  
pp. 3746 ◽  
Author(s):  
Ye Jeong ◽  
Mi-Young Lee
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase ◽  
Leaf Extract ◽  
Populus Deltoides ◽  
Nuclear Translocation ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Inflammatory Activity ◽  
No Production ◽  
Anti Inflammatory

Populus deltoides, known as eastern cottonwood, has been commonly used as a medicinal plant. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory activity of P. deltoides leaf extract (PLE). PLE effectively inhibited the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, but not that of cyclooxygenase-2 (COX-2) and prostaglandin E2. Proinflammatory tumor necrosis factor alpha (TNF-α) levels were also reduced by the extract. PLE inhibited the phosphorylation of nuclear factor-kappa B (NF-κB) and inhibitor of Kappa Bα (IκBα), and blunted LPS-triggered enhanced nuclear translocation of NF-κB p65. In mitogen-activated protein kinase (MAPK) signaling, PLE effectively decreased the phosphorylation of p38 and c-Jun N-terminal protein kinase (JNK), but not of extracellular signal-regulated kinase 1/2 (ERK1/2). Taken together, these results suggest that anti-inflammatory activity of P. deltoides leaf extract might be driven by iNOS and NO inhibition mediated by modulation of the NF-κB and p38/JNK signaling pathways.

scholarly journals Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents

2019 ◽  
Vol 65 (3) ◽  
pp. 22-31
Author(s):  
Ighodaro Igbe ◽  
Osaze Edosuyi ◽  
Agbonlahor Okhuarobo ◽  
Adarki Pongri ◽  
Nkechi Maduako ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Analgesic Effect ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Tail Flick ◽  
Hot Plate ◽  
Analgesic Effects ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Ear Oedema

Summary Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are used for the treatment of a variety of ailments in ethno-medicine. Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia barteri. Material and methods: The leaves were air-dried, powdered and repeatedly extracted with methanol using a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated for anti-inflammatory activity using carrageenan-induced paw oedema, xylene-induced ear oedema and formalin-induced arthritis tests. Analgesic effect was evaluated using acetic acid-induced mouse writhing, hot plate and tail flick tests. Results: All doses of the extract significantly (p<0.05) reduced carrageenan-induced paw oedema, however the 400 mg/kg dose gave a sustained effect. The extract significantly inhibited xylene induced ear oedema at all doses. There were no significant (p>0.05) reductions in paw swellings due to formalin. In the acetic acid induced writhing test, the extract significantly (p<0.05) decreased writhing at 400 mg/kg only. Reaction times were not significantly different from the control in the hot plate and tail flick tests. Conclusion: This study has shown that the methanol extract possesses acute anti-inflammatory and peripherally mediated analgesic effects.

scholarly journals Analgesic and anti-inflammatory activity of methanolic fraction of total ethereal leaf extract of Annona senegalensis Pers. (Annonaceae)

2017 ◽  
Vol 11 (8) ◽  
pp. 120-124 ◽  
Author(s):  
Sene Madièye ◽  
S. Barboza Firmin ◽  
Sarr Abdou ◽  
Tchemy Outouen Dominique ◽  
Wele Alassane ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet

2019 ◽  
Vol 10 (8) ◽  
pp. 4861-4867 ◽  
Author(s):  
Renata Celi Lopes Toledo ◽  
Larissa Froede Brito ◽  
Mônica Maria Magalhães Caetano ◽  
Vânia Mayumi Nakajima ◽  
Bárbara Pereira da Silva ◽  
...  
Keyword(s):  
Acute Treatment ◽  
Leaf Extract ◽  
Mangifera Indica ◽  
Cafeteria Diet ◽  
Inflammatory Activity ◽  
Liver Inflammation ◽  
Anti Inflammatory

This study investigates the acute anti-inflammatory activity of Mangifera indica L. leaf extract and mangiferin in the liver of rats fed a cafeteria diet.

Peanut leaf extract has antioxidant and anti-inflammatory activity but no acute toxic effects

2019 ◽  
Vol 107 ◽  
pp. 104407 ◽  
Author(s):  
Jocelene Filippin Cossetin ◽  
Evelyne da Silva Brum ◽  
Rosana Casoti ◽  
Camila Camponogara ◽  
Rafaela Castro Dornelles ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Toxic Effects ◽  
Anti Inflammatory ◽  
Acute Toxic
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