scholarly journals Green tea polyphenols for prostate cancer chemoprevention: A translational perspective

Phytomedicine ◽  
2010 ◽  
Vol 17 (1) ◽  
pp. 3-13 ◽  
Author(s):  
J.J. Johnson ◽  
H.H. Bailey ◽  
H. Mukhtar
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Cancer Chemoprevention ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols

scholarly journals Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 193 ◽  
Author(s):  
Yasuyoshi Miyata ◽  
Yohei Shida ◽  
Tomoaki Hakariya ◽  
Hideki Sakai
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Anti Cancer ◽  
Prevention And Treatment

Prostate cancer is the most common cancer among men. Green tea consumption is reported to play an important role in the prevention of carcinogenesis in many types of malignancies, including prostate cancer; however, epidemiological studies show conflicting results regarding these anti-cancer effects. In recent years, in addition to prevention, many investigators have shown the efficacy and safety of green tea polyphenols and combination therapies with green tea extracts and anti-cancer agents in in vivo and in vitro studies. Furthermore, numerous studies have revealed the molecular mechanisms of the anti-cancer effects of green tea extracts. We believe that improved understanding of the detailed pathological roles at the molecular level is important to evaluate the prevention and treatment of prostate cancer. Therefore, in this review, we present current knowledge regarding the anti-cancer effects of green tea extracts in the prevention and treatment of prostate cancer, with a particular focus on the molecular mechanisms of action, such as influencing tumor growth, apoptosis, androgen receptor signaling, cell cycle, and various malignant behaviors. Finally, the future direction for the use of green tea extracts as treatment strategies in patients with prostate cancer is introduced.

scholarly journals Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52572 ◽  
Author(s):  
Karishma Gupta ◽  
Vijay S. Thakur ◽  
Natarajan Bhaskaran ◽  
Akbar Nawab ◽  
Melissa A. Babcook ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Prostate Cancer Cells

Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer

2010 ◽  
Vol 6 (10) ◽  
pp. 1911 ◽  
Author(s):  
Friederike Teichert ◽  
Richard D. Verschoyle ◽  
Peter Greaves ◽  
Donald J. L. Jones ◽  
Ian D. Wilson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Metabolic Profiling ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Systemic Effects ◽  
Age Dependency

Green Tea Polyphenols and Cancer Chemoprevention of Genitourinary Cancer

2013 ◽  
pp. 92-96
Author(s):  
Howard H. Bailey ◽  
Hasan Mukhtar
Keyword(s):  
Green Tea ◽  
Cancer Chemoprevention ◽  
Protective Role ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Clinical Activity ◽  
Target Tissue ◽  
Tissue Concentrations ◽  
Predominant Form ◽  
Biologic Effects

Green tea, which has higher concentrations of polyphenols than other teas, has been correlated with reduced risk of various malignancies with most data supporting a potential protective role in prostate neoplasia. Preclinical studies over the last 25 years implicate constituent green tea catechins, epigallocatechin-3-gallate (EGCG) being the predominant form, as the main mechanistic ingredient in the observed biologic effects, which vary from proapoptotic effects to inhibition of androgen receptor and signal transduction pathways. There have been few prospective clinical trials of green tea polyphenols (GTP), especially with well-characterized formulations and doses. Although there have been hints of beneficial clinical activity in prostate neoplasia, other studies have raised concerns about the limited bioavailability and very low target-tissue concentrations of GTPs. At present there is no proven role for GTP supplementation in the prevention of genitourinary (GU) malignancies, but novel GTP formulations and further clinical testing may still support a future for GTP supplementation in GU cancer prevention.

scholarly journals Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer

2020 ◽  
Vol 11 (5) ◽  
pp. 4114-4122
Author(s):  
Susanne M. Henning ◽  
Piwen Wang ◽  
Ru-Po Lee ◽  
Amy Trang ◽  
George Husari ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Randomized Trial ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Potential Effect ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Prostate Tissue ◽  
Epicatechin Gallate ◽  
Tissue Concentrations

Epigallocatechin gallate, epicatechin gallate (Green Tea Polyphenols – GTPs) and quercetin (Q) were taken up in prostate tissue after Q and GTP consumption. Our findings herein suggest a potential effect of Q on GTP metabolism.

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