Radioprotective effect of ursolic acid in radiation-induced impairment of neurogenesis, learning and memory in adolescent BALB/c mouse

2017 ◽  
Vol 175 ◽  
pp. 37-46 ◽  
Author(s):  
Feng Ru Tang ◽  
Weng Keong Loke ◽  
Peiyan Wong ◽  
Boo Cheong Khoo
2019 ◽  
Vol 52 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Soghra Farzipour ◽  
Fereshteh Talebpour Amiri ◽  
Ehsan Mihandoust ◽  
Fatemeh Shaki ◽  
Zohreh Noaparast ◽  
...  

2015 ◽  
Vol 33 (3) ◽  
pp. 256 ◽  
Author(s):  
Seyed Jalal Hosseinimehr ◽  
Reyhaneh Nobakht ◽  
Arash Ghasemi ◽  
Tayyeb Allahverdi Pourfallah

1993 ◽  
Vol 115 (3) ◽  
pp. 275-277 ◽  
Author(s):  
I. N. Krylov ◽  
V. V. Yasnetzov ◽  
A. S. Dukhanin ◽  
Yu. P. Pal'tsev

2012 ◽  
Vol 90 (4) ◽  
pp. 415-423 ◽  
Author(s):  
Ahmed S. Nada ◽  
Asrar M. Hawas ◽  
Nour El-Din Amin ◽  
Magdy M. Elnashar ◽  
Zakaria Y. Abd Elmageed

This study was conducted to evaluate the modulatory effect of aqueous extract of Curcuma longa (L.) against γ-irradiation (GR), which induces biochemical disorders in male rats. The sublethal dose of GR was determined in primary hepatocytes. Also, the effect of C. longa extract was examined for its activity against GR. In rats, C. longa extract was administered daily (200 mg/kg body mass) for 21 days before, and 7 days after GR exposure (6.5 Gy). The lipid profile and antioxidant status, as well as levels of transaminases, interleukin-6 (IL-6), and tumour necrosis factor α (TNFα) were assessed. The results showed that in hepatocytes, the aqueous extract exhibited radioprotective activity against exposure to GR. Exposure of untreated rats to GR resulted in transaminase disorders, lipid abnormalities, elevation of lipid peroxidation, trace element alterations, release of IL-6 and TNF, and decrease in glutathione and protein level of superoxide dismutase-1 (SOD-1) and peroxiredoxin-1 (PRDX-1). However, treatment of rats with this extract before and after GR exposure improved antioxidant status and minimized the radiation-induced increase in inflammatory cytokines. Changes occurred in the tissue levels of trace elements, and the protein levels of SOD-1 and PRDX-1 were also modulated by C. longa extract. Overall, C. longa exerted a beneficial radioprotective effect against radiation-induced oxidative stress in male rats by alleviating pathological disorders and modulating antioxidant enzymes.


2021 ◽  
Vol 8 (2) ◽  
pp. 124-142
Author(s):  
Mostean Bahreinipour ◽  
◽  
Hajar Zarei ◽  
Fariba Dashtestani ◽  
Jamal Rashidiani ◽  
...  

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