Anti-inflammatory quinolizidine alkaloids from the aerial parts of Sophora tonkinensis

Background: Some Bupleurum species, such as the Bupleurum chinense DC. or the Bupleurum scorzonerifolium Willd have been extensively studied (especially their roots) for the treatment of inflammation. In contrast, only compounds extracted from the aerial parts of Bupleurum rotundifolium have been studied and showed anti-inflammatory or antiproliferative activities. This study was conducted to investigate the antioxidant, anti-inflammatory, and immunomodulatory effects of Bupleurum rotundifolium roots. Methods: To tackle the various aspects of inflammation, we studied in vitro a methanolic extract from the roots of Bupleurum rotundifolium on peripheral blood mononuclear cells (PBMCs), polymorphonuclear neutrophils (PMNs), and the monocytic cells THP-1. Its antioxidant capacities and iron-chelating activity were assessed. The extract was tested on THP-1 differentiation, reactive oxygen species (ROS) production by leukocytes, neutrophils chemotaxis, cytokines, PGE2 production, and NF-κB activation in PBMCs. Results: The extract showed a decreased ROS production in stimulated cells. It increased PBMC chemokine secretion and up-regulated the differentiation of THP-1 monocytes into macrophage-like cells, indicating a potential interest of the extract in the resolution of acute inflammation. In addition, the analysis of cytokine production suggests that Bupleurum rotundifolium has immunomodulatory properties. Conclusions: Cytokines secretion, especially IL-1β and IL-12p70, provided us with a set of indicators suggesting that the extract might be able to drive the polarization of macrophages and lymphocytes toward a Th2 anti-inflammatory profile in excessive inflammation.

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Iridoids with anti-inflammatory effect from the aerial parts of Morinda officinalis How

Fitoterapia ◽

10.1016/j.fitote.2021.104991 ◽

2021 ◽

pp. 104991

Author(s):

Miaomiao Cai ◽

Mengyun Liu ◽

Pengxiao Chen ◽

Hong Liu ◽

Yifei Wang ◽

...

Keyword(s):

Aerial Parts ◽

Anti Inflammatory ◽

Inflammatory Effect

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Antibacterial and anti-inflammatory activities of an extract, fractions, and compounds isolated from Gochnatia pulchra aerial parts

Brazilian Journal of Medical and Biological Research ◽

10.1590/1414-431x20154410 ◽

2015 ◽

Vol 48 (9) ◽

pp. 822-830 ◽

Cited By ~ 7

Author(s):

R. Lucarini ◽

M.G. Tozatti ◽

M.L.A. Silva ◽

V.M.M. Gimenez ◽

P.M. Pauletti ◽

...

Keyword(s):

Aerial Parts ◽

Anti Inflammatory

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MIRACLE AYURVEDIC HERB - ASHWAGANDHA (WITHANIA SOMNIFERA DUNAL)

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj2909082021 ◽

2021 ◽

Vol 9 (8) ◽

pp. 1778-1788

Author(s):

Bargale Sushant Sukumar

Keyword(s):

Withania Somnifera ◽

Chemical Constituents ◽

Immunomodulatory Activity ◽

Indian Ginseng ◽

Aerial Parts ◽

Wide Range ◽

The World ◽

Anti Inflammatory ◽

Ayurvedic Herb ◽

Present World

Ayurveda is successfully implemented as a primary healthcare system in India, and it is flourishing in the promotion of health around the world. Ayurveda aims to create a society happily, healthy, and peaceful. In general, the simple regimes mentioned in Ayurveda texts are of immense use faced by the present world today regarding health pro- motion. Ashwagandha (Withania Somnifera) is usually referred to as 'Indian winter cherry' or 'Indian Ginseng'. It is a shrub grown in India and North America whose roots have been used by Ayurvedic practitioners for thousands of years. Ashwagandha is one of Ayurveda's most essential herbs, used as Rasayana for its wide range of health benefits for centuries. Chemicals constitute of Ashwagandha (Withania Somnifera)- The chemistry of Ashwagan- dha (Withania Somnifera) has been widely studied and numerous categories of chemical constituents have been described, extracted, and isolated, such as steroidal lactones, alkaloids, flavonoids, tannin, etc. More than 12 alka- loids, 40 withanolides and several sitoindosides have currently been isolated from the aerial parts, roots, and berries of the Withania species and have been recorded. The principal biochemical element of Ashwagandha (WS) root is withanolides, which are steroidal alkaloids and steroidal lactones. The pharmacological activity of Ashwagan- dha- It has been shown to have pharmacological importance as an Adaptogen, Antibiotic, abortifacient, aphrodisiac, Astringent, Anti-inflammatory, deobstructive, diuretic, narcotic, sedative, and tonic through centuries of Ayurvedic medicinal practice using Ashwagandha (Withania Somnifera). Along with these Ashwagandha acts as Anti-stress,Anticarcinogenic activity, Anti-inflammatory activity, Anti-aging activity, Cardioprotective activity, hypothyroid activity and Immunomodulatory activity. Keywords: Ashwagandha, Withania Somnifera, Alkaloids, Withanoids, sitoindosides

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Anti-inflammatory and anti-nociceptive effects of hydroalchoholic extract of Nepeta menthoides on pain in aerial parts in male mice

Pars of Jahrom University of Medical Sciences ◽

10.29252/jmj.11.3.1 ◽

2013 ◽

Vol 11 (3) ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Sosan Asadi Balsin Sharif Abadi1 ◽

Sima Nasri ◽

Gholamreza Amin ◽

Sayeh Bidaran

Keyword(s):

Male Mice ◽

Aerial Parts ◽

Anti Inflammatory

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Phytochemical Analysis of Podospermum and Scorzonera n-Hexane Extracts and the HPLC Quantitation of Triterpenes

Molecules ◽

10.3390/molecules23071813 ◽

2018 ◽

Vol 23 (7) ◽

pp. 1813 ◽

Cited By ~ 4

Author(s):

Özlem Bahadır-Acıkara ◽

Serkan Özbilgin ◽

Gülcin Saltan-İşcan ◽

Stefano Dall’Acqua ◽

Veronika Rjašková ◽

...

Keyword(s):

Hplc Method ◽

Phytochemical Analysis ◽

Qualitative And Quantitative Analysis ◽

Qualitative And Quantitative ◽

Aerial Parts ◽

Hexane Extracts ◽

Lupeol Acetate ◽

Anti Inflammatory

Previously tested n-hexane extracts of the Scorzonera latifolia showed promising bioactivity in vivo. Because triterpenes could account for this activity, n-hexane extracts were analyzed by HPLC to identify and quantify the triterpenes as the most abundant constituents. Other Scorzonera and Podospermum species, potentially containing triterpenic aglycones, were included in the study. An HPLC method for simultaneous determination of triterpene aglycones was therefore developed for analysis of Podospermum and Scorzonera species. n-Hexane extracts of root and aerial parts of S. latifolia, ten other Scorzonera species and two Podospermum species were studied to compare the content of triterpenes. HPLC was used for the qualitative and quantitative analysis of α-amyrin, lupeol, lupeol acetate, taraxasteryl acetate, 3-β-hydroxy-fern-7-en-6-one acetate, urs-12-en-11-one-3-acetyl, 3-β-hydroxy-fern-8-en-7-one acetate, and olean-12-en-11-one-3-acetyl. Limits of detection and quantification were determined for each compound. HPLC fingerprinting of n-hexane extracts of Podospermum and Scorzonera species revealed relatively large amounts of triterpenes in a majority of investigated taxa. Lupeol, lupeol acetate, and taraxasteryl acetate were found in a majority of the species, except S. acuminata. The presence of α-amyrin, 3β-hydroxy-fern-7-en-6-one-acetate, urs-12-en-11-one-3-acetyl, 3β-hydroxy-fern-8-en-7-one-acetate, and olean-12-en-11-one-3-acetyl was detected in varying amounts. The triterpene content could correlate with the analgesic and anti-inflammatory activity of Scorzonera, which was previously observed and Scorzonera species that have been determined to contain triterpenes in large amounts and have not yet been tested for their analgesic activity should be tested for their potential analgesic and anti-inflammatory potential. The presented HPLC method can be used for analysis of triterpene aglycones, for example dedicated to chemosystematic studies of the Scorzonerinae.

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