Iridoids with anti-inflammatory effect from the aerial parts of Morinda officinalis How

Background: Anthocephalus cadamba (Rebox)Miq. (Rubiaceae) is widely distributed throughout the greater part of India, especially at low levels in wet place. Traditionally the bark is used as tonic, febrifuge and to reduce the pain and inflammation. The anti-inflammatory effect of methanol extract obtained from Anthocephalus cadamba aerial parts, MEAC, were investigated in this study. Design and methods: The effects of MEAC on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin) induced paw edema and cotton pallet-induced granuloma, respectively. The anti-edema effect of MEAC was compared with 10 mg/kg of indomethacin orally. Results: The results suggested that MEAC possess potent anti-inflammatory activity. The acute inflammatory model showed that all the doses of MEAC effectively suppressed the edema produced by histamine, so it may be suggested that its anti-inflammatory activity is possibly backed by its antihistaminic activity. In chronic inflammatory model the effect may be due to the cellular migration to injured sites and accumulation of collagen and mucopolysaccharide. Conclusions: On the basis of these findings, it may be inferred that Anthocephalus cadamba is an anti-inflammatory agent and the results are in agreement with its traditional use.

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Protocatechuic aldehyde from Salvia miltiorrhiza exhibits an anti-inflammatory effect through inhibiting MAPK signalling pathway

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-020-03090-4 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Shuang Wu ◽

Qingyu Wang ◽

Jinquan Wang ◽

Baoyu Duan ◽

Qihe Tang ◽

...

Keyword(s):

Salvia Miltiorrhiza ◽

Inflammatory Factors ◽

Histopathological Analysis ◽

Mapk Signalling Pathway ◽

Aerial Parts ◽

Protocatechuic Aldehyde ◽

Anti Inflammatory ◽

Inflammatory Effect

Abstract Background The aerial parts of Salvia miltiorrhiza, which was considered to be the waste part and discarded during the root harvest, is rich in protocatechuic aldehyde (PAI). This study investigated the health-promoting effects of extracts and PAI from the aerial parts of Salvia miltiorrhiza, including its anti-inflammatory effects and the underlying mechanisms of action in vitro and in vivo. Method Purification of the sample paste of Salvia miltiorrhiza was accomplished using HPLC analysis. TheMTT (Methylthiazolyldiphenyl-tetrazolium bromide) assay was employed to determine the cell viability. The production of inflammatory factors was detected by ELISA assays. The histopathological analysis was used to analyse the lungs and livers of mice treated with PAI. Western blot was performed to reveal the mechanism of PAI in anti-inflammatory. Results The extracts and PAI from the aerial parts of Salvia miltiorrhiza inhibited TNF-α, IL-6 production and promoted the production of IL-10 in vivo in mice and in vitro in the macrophage cell line RAW264.7. NF-κB and MAPKs kinase phosphorylation were also suppressed by PAI in vivo and in vitro, indicating that PAI exhibited an anti-inflammatory effect. Conclusion These findings suggest that the aerial parts of Salvia miltiorrhiza extract may serve as potential protective agents for inflammatory.

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In vitro Anti-inflammatory Effect of Carthamus lanatus L.

Zeitschrift für Naturforschung C ◽

10.1515/znc-2003-11-1215 ◽

2003 ◽

Vol 58 (11-12) ◽

pp. 830-832 ◽

Cited By ~ 5

Author(s):

Saima Jalil ◽

Bozhanka Mikhova ◽

Rilka Taskova ◽

Maya Mitova ◽

Helmut Duddeck ◽

...

Keyword(s):

Inflammatory Activity ◽

Human Neutrophils ◽

Inhibitory Effects ◽

Aerial Parts ◽

Anti Inflammatory ◽

Inflammatory Effect

Abstract The anti-inflammatory activity of four total extracts, their fractions and two main constituents (α-bisabolol β-ᴅ-fucopyranoside and luteolin 7-O-glucoside) of Carthamus lanatus L. aerial parts, were assessed in vitro by determining the inhibitory effects on induced human neutrophils. The dichloromethane extract and its water-alcoholic part exhibited the most significant inhibitory effects.

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Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000620 ◽

2019 ◽

pp. 1-9

Author(s):

Samira Salem ◽

Essaid Leghouchi ◽

Rachid Soulimani ◽

Jaouad Bouayed

Keyword(s):

Time Course ◽

Acute Inflammation ◽

Lichen Species ◽

Paw Edema ◽

Sod Activity ◽

Edema Formation ◽

Lobaria Pulmonaria ◽

Anti Inflammatory ◽

Endogenous Antioxidant ◽

Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

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Anti-inflammatory effect of Curcuma longa (turmeric) rhizome when administered topically in gel form

Planta Medica ◽

10.1055/s-0029-1234748 ◽

2009 ◽

Vol 75 (09) ◽

Cited By ~ 1

Author(s):

AH Mollik ◽

W Mozammel Haq ◽

S Chandra Bachar ◽

R Jahan ◽

M Rahmatullah

Keyword(s):

Curcuma Longa ◽

Anti Inflammatory ◽

Inflammatory Effect

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Anti-inflammatory effect of Mitragyna speciosa crude methanol extract on the guinea pig ileum

Planta Medica ◽

10.1055/s-0029-1234736 ◽

2009 ◽

Vol 75 (09) ◽

Cited By ~ 1

Author(s):

WM Shaik Mossadeq ◽

K Syamimi ◽

MP Azyyati ◽

ZA Zakaria ◽

AK Arifah ◽

...

Keyword(s):

Guinea Pig ◽

Methanol Extract ◽

Guinea Pig Ileum ◽

Mitragyna Speciosa ◽

Anti Inflammatory ◽

Crude Methanol Extract ◽

Inflammatory Effect

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Anti-inflammatory effect of Uncaria tomentosa in an experimental model of cyclophosphamide-induced hemorrhagic cystitis

Planta Medica ◽

10.1055/s-0032-1320641 ◽

2012 ◽

Vol 78 (11) ◽

Author(s):

IST Figueiredo ◽

FT Benevides ◽

NMS Queiroz ◽

LM Marques ◽

TFG Souza ◽

...

Keyword(s):

Experimental Model ◽

Hemorrhagic Cystitis ◽

Uncaria Tomentosa ◽

Anti Inflammatory ◽

Inflammatory Effect

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Phytochemical analysis of aerial parts of Persicaria bistorta (L.) Samp. and the evaluation of the anti-inflammatory potential of rare malonylated flavonols

Planta Medica ◽

10.1055/s-0036-1596543 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381

Author(s):

U Klimczak ◽

M Woźniak ◽

M Tomczyk ◽

S Granica

Keyword(s):

Phytochemical Analysis ◽

Aerial Parts ◽

Anti Inflammatory

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Therapeutic use of lowmolecular weight heparin for capillaritis alba

Phlebologie ◽

10.1055/s-0037-1622240 ◽

2008 ◽

Vol 37 (05) ◽

pp. 259-265 ◽

Cited By ~ 11

Author(s):

H. Kutzner ◽

G. Hesse

Keyword(s):

Case Studies ◽

Randomized Study ◽

Compression Therapy ◽

Venous Hypertension ◽

Therapeutic Use ◽

Prospective Randomized Study ◽

Anti Inflammatory ◽

Positive Effect ◽

Inflammatory Effect

SummaryThe reason of the so called ulcerated capillaritis alba or idiopathic atrophie blanche is vasculopathy caused by severe venous hypertension. Thrombosed and rarificated vessels worsen the oxygenation, increase permanent inflammation and impede the necessary compression therapy. The anti-inflammatory effects of heparin alleviate pain and being independent from the antithrombotic ones it needs much lower doses for treatment. This anti-inflammatory effect is now becoming more important in clinical phlebology. Case studies of more than 50 patients and one prospective randomized study of 87 patients clearly demonstrate the ameliorated healing of ulcerated atrophie blanche. In our office we could document this positive effect with 22 patients. We present the pathophysiology of low molecular heparins for ulcerated capillaritis alba and our own experiences with it.

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