Benign Myofibroblastic/Epithelial Lesions of the Breast with Minimally Infiltrative Margins

A variant of ductal carcinoma of the human breast which has been designated apocrine carcinoma has distinctive light and electron microscopic features. Such tumors comprise approximately 0.5% of breast carcinomas. Abundant cytoplasmic membrane bound vesicles (400-600 nm) with dense homogeneous osmophilic cores characterize these tumors. These granules are also seen in apocrine metaplastic breast epithelial lesions1 and appear to be responsible for the finely granular eosinophilic cytoplasm observed by light microscopy. A high content of intermediate affinity non-saturable 4S progesteroneestrogen binding protein (PEBP) in apocrine carcinoma has been reported.2 The present ultrastructural study evaluates the presence of apocrine granules in infiltrating ductal carcinoma (NOS) to determine if a correlation exists between apocrine granule content and the quantity of PEBP present.

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Fibro-epithelial lesions with serial growth/stromal cellularity: pre-op factors suggesting a phyllodes tumour diagnosis.

10.26226/morressier.596648e5d462b80290b52169 ◽

2017 ◽

Author(s):

Ralph George

Keyword(s):

Tumour Diagnosis ◽

Phyllodes Tumour ◽

Epithelial Lesions

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Non-malignant conjunctival epithelial masses with ocular surface squamous neoplasia-like optical coherence tomography features

International Ophthalmology ◽

10.1007/s10792-021-01743-y ◽

2021 ◽

Author(s):

Ágnes Füst ◽

Jeannette Tóth ◽

László Imre ◽

Zoltán Zsolt Nagy

Keyword(s):

Optical Coherence Tomography ◽

Ocular Surface ◽

Anterior Segment ◽

Histological Diagnosis ◽

Optical Coherence ◽

Ocular Surface Squamous Neoplasia ◽

Ocular Coherence Tomography ◽

Maximal Thickness ◽

Epithelial Lesions ◽

Mass Lesions

Abstract Purpose To observe and describe the anterior segment optical coherence tomography features of limbally localised non-malignant epithelial mass lesions Methods Thirteen patients (age: 66.9 ± 16.3 years) with conjunctival mass suggesting ocular surface squamous neoplasia with biomicroscopic examination were imaged using anterior segment ocular coherence tomography (anterior segment optical coherence tomography)/Cirrus HD-OCT, Model 4000, Carl Zeiss Meditec, Inc., Dublin, CA, and Spectralis HRA + OCT system, Heidelberg Engineering, Vista, CA/. Cases with ocular surface squamous neoplasia-like anterior segment optical coherence tomography (hyperreflective, thickened epithelium and an abrupt transition from normal to abnormal) were included in the study. Maximal thickness of the epithelium was measured. Histological diagnosis was gained from an excisional or incisional biopsy or impression cytology specimens. Results In six patients (age: 68.5 ± 15.4 years) with ocular surface squamous neoplasia-like anterior segment optical coherence tomography features, the histological diagnosis was other than ocular surface squamous neoplasia (papilloma, parakeratosis and a keratotic plaque with mild dysplasia), and ocular surface squamous neoplasia in seven cases (age: 65.6 ± 18.0 years). The maximal epithelial thickness was between 250 and 859 µm in non-ocular surface squamous neoplasia cases and between 252 and 596 µm in ocular surface squamous neoplasia cases. Conclusion Non-malignant epithelial lesions can mimic ocular surface squamous neoplasia on anterior segment optical coherence tomography.

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Regression of low-grade squamous intra-epithelial lesions in young women

Obstetrics and Gynecology ◽

10.1097/01.aog.0000153254.32711.2a ◽

2005 ◽

Vol 105 (2) ◽

pp. 434

Keyword(s):

Young Women ◽

Low Grade ◽

Epithelial Lesions

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Plutonium-induced Proliferative Lesions and Pulmonary Epithelial Neoplasms in the Rat: Immunohistochemical and Ultrastructural Evidence for Their Origin from Type II Pneumocytes

Veterinary Pathology ◽

10.1177/030098589403100310 ◽

1994 ◽

Vol 31 (3) ◽

pp. 366-374 ◽

Cited By ~ 14

Author(s):

R. A. Herbert ◽

B. S. Stegelmeier ◽

N. A. Gillett ◽

A. H. Rebar ◽

W. W. Carlton ◽

...

Keyword(s):

Clara Cell ◽

Normal Lung ◽

Type Ii ◽

Epithelial Hyperplasia ◽

Cell Antigen ◽

Alveolar Epithelial ◽

Type Ii Pneumocytes ◽

Epithelial Neoplasms ◽

Epithelial Lesions ◽

Surfactant Apoprotein

Immunohistochemistry and transmission electron microscopy were used to clarify the cellular origin for plutonium-239-induced pulmonary proliferative (preneoplastic) epithelial lesions and epithelial neoplasms in F344 rats. Examples of each histologic type of proliferative lesion and neoplasm were stained by the avidin-biotin complex immunoperoxidase method using antibodies to rat surfactant apoprotein and Clara cell antigen. Rat surfactant apoprotein immunostaining was detected in type II pneumocytes in sections of normal lung, in the cells of the proliferative lesions classified histologically as alveolar epithelial hyperplasia (51) and mixed foci (alveolar epithelial hyperplasia with fibrosis) (30), and in adenomas (2), adenocarcinomas (3), and adenosquamous carcinomas (2). With the exception of one adenosquamous carcinoma, Clara cell antigen immunostaining was not detected in any of the pulmonary lesions but was detected in nonciliated cuboidal epithelial (Clara) cells in normal bronchioles. The epithelial cells of the proliferative lesions and neoplasms had ultrastructural features consistent with type II pneumocytes, i.e., the presence of cytoplasmic lamellar and multivesicular bodies. The results of these studies indicate that the majority of plutonium-induced proliferative epithelial lesions and neoplasms in the rat originate from alveolar type II pneumocytes.

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Compact Endoscopy of the Larynx

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940311200203 ◽

2003 ◽

Vol 112 (2) ◽

pp. 113-119 ◽

Cited By ~ 50

Author(s):

Christoph Arens ◽

Thomas Dreyer ◽

Hiltrud Glanz ◽

Karin Malzahn

Keyword(s):

Laryngeal Cancer ◽

Carcinoma In Situ ◽

Preoperative Assessment ◽

Laryngeal Mucosa ◽

Grade Ii ◽

Cancerous Lesions ◽

Epithelial Layers ◽

Epithelial Lesions ◽

Autofluorescence Endoscopy

In order to improve preoperative assessment of suspected precancerous and cancerous lesions of the larynx, we examined 83 patients by compact endoscopy (combination of autofluorescence and contact endoscopy) during microlaryngoscopy in a pilot study. The intraoperative findings were related to histopathologic examination. Cancerous laryngeal mucosa was illuminated during autofluorescence endoscopy by use of blue filtered light (D-light AF system) for optical demarcation of the lesion. After staining the mucosa with methylene blue (1%), we performed contact endoscopy. During autofluorescence examination of the endolaryngeal mucosa, the appearance of precancerous and cancerous lesions varied between opaque light areas and darker reddish areas. By contact endoscopy, it was possible to observe the cells, nuclei, and cytoplasm, as well as different degrees of abnormality. Histopathologic findings of 83 patients revealed laryngeal dysplasia (grade I in 29 patients, grade II in 15, and grade III or carcinoma in situ in 8) and laryngeal cancer (31 patients). In 73 cases (88%), the findings of compact endoscopy corresponded to those of histopathology. In 5 cases, epithelial lesions were overestimated because of inflammation and scarring, and 5 cases were underestimated because of hyperkeratotic thickening of the mucosa covering basal epithelial layers with focal dysplasia of grades II and III, carcinoma in situ, and microinvasive cancer. We conclude that compact endoscopy enables the laryngologist to assess laryngeal cancer and its preceding lesions more accurately during microlaryngoscopy.

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Human Papillomavirus in Various Lesions of the Head and Neck

Otolaryngology ◽

10.1177/019459988509300310 ◽

1985 ◽

Vol 93 (3) ◽

pp. 342-346 ◽

Cited By ~ 18

Author(s):

Melvin Strauss ◽

A. Bennett Jenson

Keyword(s):

Human Papillomavirus ◽

Oral Cavity ◽

Head And Neck ◽

Adult Onset ◽

Childhood Onset ◽

Oncogenic Potential ◽

Suggestive Evidence ◽

Malignant Lesions ◽

Epithelial Lesions

The association of human papillomavirus with benign and malignant epithelial lesions of the head and neck has been studied by a peroxidase-antiperoxidase technique having immunospecificity against genus-specific structural antigens of the papillomaviruses. More than 360 specimen blocks from 144 patients were evaluated. There was evidence of human papillomavirus antigen in three out of eight patients with childhood-onset laryngeal papillomas (37.5%) and in four out of eight patients with adult-onset papillomas (50%). A patient with an unusual flat, wartlike lesion appearing as an oral cavity leukoplakia had detectable papillomavirus antigen in it. None of the 13 cases of inverting papilloma or any of the malignant lesions studied showed evidence for the presence of papillomavirus antigen. There is currently only suggestive evidence for the oncogenic potential of human papillomavirus in the head and neck.

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