Human Papillomavirus in Various Lesions of the Head and Neck

1985 ◽  
Vol 93 (3) ◽  
pp. 342-346 ◽  
Author(s):  
Melvin Strauss ◽  
A. Bennett Jenson
Keyword(s):  
Human Papillomavirus ◽  
Oral Cavity ◽  
Head And Neck ◽  
Adult Onset ◽  
Childhood Onset ◽  
Oncogenic Potential ◽  
Suggestive Evidence ◽  
Malignant Lesions ◽  
Epithelial Lesions

The association of human papillomavirus with benign and malignant epithelial lesions of the head and neck has been studied by a peroxidase-antiperoxidase technique having immunospecificity against genus-specific structural antigens of the papillomaviruses. More than 360 specimen blocks from 144 patients were evaluated. There was evidence of human papillomavirus antigen in three out of eight patients with childhood-onset laryngeal papillomas (37.5%) and in four out of eight patients with adult-onset papillomas (50%). A patient with an unusual flat, wartlike lesion appearing as an oral cavity leukoplakia had detectable papillomavirus antigen in it. None of the 13 cases of inverting papilloma or any of the malignant lesions studied showed evidence for the presence of papillomavirus antigen. There is currently only suggestive evidence for the oncogenic potential of human papillomavirus in the head and neck.

scholarly journals The effects of topical treatment with 5-fluorouracil on potentially malignant lesions of mice oral mucosa

2015 ◽  
Vol 32 (02) ◽  
pp. 082-088
Author(s):  
G. Costa ◽  
E. Almeida ◽  
F. Cavalcanti ◽  
J. Castro
Keyword(s):  
Oral Cavity ◽  
Patient Involvement ◽  
Antineoplastic Agent ◽  
Chemotherapeutic Drugs ◽  
Cure Rate ◽  
Lingual Mucosa ◽  
Significant Difference ◽  
Potentially Malignant ◽  
Malignant Lesions ◽  
Epithelial Lesions

Abstract Introduction: The 5-fluorouracil (5-FU) discloses a cure rate greater than 90 percent in potentially malignant lesions of skin. In the oral cavity, these lesions are treat in most cases with practice surgery, which reduces the number of patient involvement by malignant lesions, not being usual treatment with chemotherapeutic drugs. The aim of this study was to evaluate the effectiveness of the antineoplastic agent 5-fluorouracil in orabase® in potentially malignant lesions of the lingual mucosa in mice. Materials and Methods: Swiss albino mice (Mus musculus) were submitted to carcinogen 4-nitroquinoline-1-oxide (4NQO), 100 μg/ml in drinking water for 8 weeks, and on developing potentially malignant lesions on the tongue, were treated daily, with topical 5-FU in orabase® at concentrations of 0.5% and 5%, for 3 weeks. The tongues were processed for analysis by light microscopy. Results: Treatment with 5-FU in orabase® was shown to be effective in the histological degree of involution of the epithelial lesions of the tongue in the treated animals (p<0.05). However, when compared, there was no statistically significant difference between the two concentrations (p>0.05). Conclusions: The 5-FU in orabase® was shown to be a feasible therapy in potentially malignant lesions of the oral cavity.

scholarly journals Prevalence of Human Papillomavirus (HPV) Infection and the Association with Survival in Saudi Patients with Head and Neck Squamous Cell Carcinoma

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 820 ◽  
Author(s):  
Ghazi Alsbeih ◽  
Najla Al-Harbi ◽  
Sara Bin Judia ◽  
Wejdan Al-Qahtani ◽  
Hatim Khoja ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Stage ◽  
Hpv Infection ◽  
Double Negative ◽  
Hpv Dna

Head and neck squamous cell carcinoma (HNSCC) shows wide disparities, association with human papillomavirus (HPV) infection, and prognosis. We aimed at determining HPV prevalence, and its prognostic association with overall survival (OS) in Saudi HNSCC patients. The study included 285 oropharyngeal and oral-cavity HNSCC patients. HPV was detected using HPV Linear-Array and RealLine HPV-HCR. In addition, p16INK4a (p16) protein overexpression was evaluated in 50 representative cases. Oropharyngeal cancers were infrequent (10%) compared to oral-cavity cancers (90%) with no gender differences. Overall, HPV-DNA was positive in 10 HNSCC cases (3.5%), mostly oropharyngeal (21%). However, p16 expression was positive in 21 cases of the 50 studied (42%) and showed significantly higher OS (p = 0.02). Kaplan–Meier univariate analysis showed significant associations between patients’ OS and age (p < 0.001), smoking (p = 0.02), and tumor stage (p < 0.001). A Cox proportional hazard multivariate analysis confirmed the significant associations with age, tumor stage, and also treatment (p < 0.01). In conclusion, HPV-DNA prevalence was significantly lower in our HNSCC patients than worldwide 32–36% estimates (p ≤ 0.001). Although infrequent, oropharyngeal cancer increased over years and showed 21% HPV-DNA positivity, which is close to the worldwide 36–46% estimates (p = 0.16). Besides age, smoking, tumor stage, and treatment, HPV/p16 status was an important determinant of patients’ survival. The HPV and/or p16 positivity patients had a better OS than HPV/p16 double-negative patients (p = 0.05). Thus, HPV/p16 status helps improve prognosis by distinguishing between the more favorable p16/HPV positive and the less favorable double-negative tumors.

Prevalence of Human Papillomavirus in Malignant Lesions of the Oral Cavity and its Association With Risk Factors for Oral Cancer

2015 ◽  
Vol 120 (2) ◽  
pp. e102
Author(s):  
KAMILE LEONARDI DUTRA ◽  
BRUNO EDUARDO SILVA DE ARAUJO ◽  
MARIA LUIZA BAZZO ◽  
ELENA RIET CORREA RIVERO ◽  
ALEXANDRE SHERLLEY CASIMIRO ONOFRE
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Malignant Lesions

scholarly journals Clinico-Histological presentation of Head and Neck Lesions in a Tertiary Care Hospital

2021 ◽  
Vol 25 (1) ◽  
pp. 21-25
Author(s):  
Mohammad Sajjad Kattak ◽  
Abdul Ghafoor ◽  
Rafi Ullah ◽  
Asif Mehmmod ◽  
Mohammad Iqbal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Basal Cell ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Malignant Lesions

Objective: This study aimed to see the clinical presentation and histological pattern of various head and neck lesions.Materials and Methods: This descriptive study was conducted in the Department of Pathology, Bannu Medical College in association with the Department of Surgery and ENT, Khalifa Gul Nawaz Teaching Hospital, Bannu. A total of 184 cases of head and neck lesions biopsy were subjected to histopathological diagnosis. Patients' age, gender, anatomical location, and other relevant necessary clinical findings were recorded on an already designed proforma. All biopsies were received in 10% buffered formalin, fixed overnight, and processed for histopathological examination and diagnosis. Inclusion criteria were patients with head and neck lesions including skin, salivary gland, lymph node, and oral cavity of any age and gender. Exclusion criteria were thyroid, nasal cavity lesions, autolysed, and insufficient biopsy specimen. Results: In this study, the mean age was 28.58 ± 17.34 years, and the age range was from 10 to 80 years. The male-to-female ratio was 1.3:1. The most common age group was 36-45 years followed by 46-55 years and 26-35 years etc. The most common inflammatory lesion was granulomatous lymphadenitis 14.67% followed by reactive lymphoid hyperplasia 9.23%. Common benign lesions were pleomorphic adenoma 5.97% followed by lipoma and hemangioma 3.80% and 3.26% respectively. Amongst malignant lesions basal cell carcinoma 23.91% of the face was the commonest lesion followed by squamous cell carcinoma 22.28% of the oral cavity. Conclusion: This study show spectrum of lesions from inflammatory to benign and malignant, occurring in the head and neck region. Malignant lesions are more common as compared to benign and inflammatory lesions, basal cell carcinoma of the skin is the commonest malignant lesion followed by squamous cell carcinoma of the skin and oral cavity.

scholarly journals Human Papillomavirus Detection in Head and Neck Squamous Cell Carcinomas at a Tertiary Hospital in Sub-Saharan Africa

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Evans Aboagye ◽  
Francis Agyemang-Yeboah ◽  
Babatunde Moses Duduyemi ◽  
Christian Obirikorang
Keyword(s):  
Human Papillomavirus ◽  
Oral Cavity ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tertiary Hospital ◽  
Sub Saharan Africa ◽  
Cross Sectional ◽  
Hpv 16 ◽  
Sub Saharan ◽  
Oral Cavity Cancers

Fewer studies have been done over the years to establish the association of human papillomavirus (HPV) with head and neck squamous cell carcinoma (HNSSC) within the subregions of sub-Saharan Africa, and thus this study was designed to investigate the presence of HPV in HNSCC at a tertiary hospital in Ghana, providing additional evidence on the need to explore similar studies in other subregions. A retrospective cross-sectional study was employed to investigate the presence of the DNA of HPV genotypes in HNSCC archived tissue. A total of 100 HNSCC cases were classified as suitable for HPV genotyping. HPV-DNA was detected in 18% of the HNSCC cases, with 17 being HPV-16 and 1 dual infection with HPV-16 and HPV-18. HPV was prevalent in 50% of oropharyngeal cancers, 27% of laryngeal cancers, and 23% of oral cavity cancers. HPV E6/E7 oncogenic DNA was found in 18% of the HNSCC cases, with HPV-16 being the predominant genotype present. The pattern of HPV association was similar to earlier reported studies, recording a higher prevalence in oropharyngeal cancers, followed by laryngeal cancers and oral cavity cancers.

scholarly journals Knowledge of Human Papillomavirus and its Association with Head and Neck Benign and Malignant Lesions in a Group of Dental Patients in Pakistan

2015 ◽  
Vol 16 (4) ◽  
pp. 1581-1585
Author(s):  
Abdul Samad Gichki ◽  
Waranun Buajeeb ◽  
Sombhun Doungudomdacha ◽  
Siribang-On Pibooniyom Khovidhunkit
Keyword(s):  
Human Papillomavirus ◽  
Head And Neck ◽  
Dental Patients ◽  
Malignant Lesions

scholarly journals Smoking, alcohol consumption and human papillomavirus infection as risk factors for oral cavity and oropharyngeal tumors in Serbia - a pilot study

2020 ◽  
Vol 77 (7) ◽  
pp. 740-745
Author(s):  
Ljiljana Bozic ◽  
Predrag Jeremic ◽  
Milovan Dimitrijevic ◽  
Tanja Jovanovic ◽  
Aleksandra Knezevic
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
High Risk ◽  
Alcohol Consumption ◽  
Oral Cavity ◽  
Tongue Cancer ◽  
Hpv Infection ◽  
Benign Lesions ◽  
Significant Difference ◽  
Malignant Lesions

Background/Aim. The oral cavity and oropharyngeal cancers are among the most common cancers worldwide with the multifactorial etiology. The aim of this study was to determine the major risk factors among patients with oral cavity and oropharyngeal tumors in Serbia. Methods. A total of 63 patients with biopsy proven malignant (33 patients) or benign (30 patients) oral cavity or oropharyngeal lesions were included in this study. The data about gender, age, smoking habits and alcohol consumption were obtained from the routine medical files. The detection and genotyping of human papillomavirus (HPV) was done in paraffin embedded tissue samples using in situ hybridization. Results. Malignant lesions were more frequent in men, smokers and patients who consume alcohol with a statistically significant difference compared to the patients with benign lesions. The prevalence of HPV infection was higher in patients with malignant lesions compared to patients with benign lesions, but without statistically significant difference. High risk genotypes were detected only in patients with malignant lesions of tonsils and base tongue cancer, while low risk types were demonstrated in patients with benign lesions with a highly statistically significant difference. Conclusion. The results point to the significant association of tobacco smoking, alcohol consumption and high risk HPV genotypes as risk factors for oral cavity and oropharyngeal carcinomas in Serbian patients.

scholarly journals Demographics and targeted biopsy with NBI in head and neck mucosal lesions

2020 ◽  
Vol 6 (11) ◽  
pp. 2064
Author(s):  
Pranay Bhandari ◽  
Kavita Sachdeva
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Correct Diagnosis ◽  
Age Distribution ◽  
Targeted Biopsy ◽  
Female Ratio ◽  
Malignant Lesions ◽  
Mucosal Lesions

<p class="abstract"><strong>Background:</strong> It is estimated that by the end of year 2020 over 10 million people worldwide would die of cancer every year and about 66% of these would be from developing world like India (WHO-UCC 2003). Our aim in present study was to evaluate the use of targeted biopsy of mucosal lesions of head and neck cancer using narrow band imaging technique, in order to yield more accurate specimen of lesion which will result in correct diagnosis of disease early and to study different demographics of patients.</p><p class="abstract"><strong>Methods:</strong> Patients lesions were examined under NBI endoscope, best site of biopsy were identified on the basis of increase vascularity, neo-angiogenesis and superficial capillary vessels. Biopsy were taken from this site and sent for histopathological examinations. Considering histopathological report as standard, results from NBI endoscopy were compared to the results of previous studies and conclusion was done. We also studied different demographics of these patients under site of lesion, age distribution, sex distribution, and locality, histopathology type.  </p><p class="abstract"><strong>Results:</strong> Maximum lesions were found in oral cavity (56.33%). Malignancy was also more common in oral cavity (63.46%), mostly belong to squamous cell carcinoma on histopathology. Mean age of presentation of head and neck mucosal lesion was found to be 48 year and of malignant lesions is 54 years.</p><p class="abstract"><strong>Conclusions:</strong> We conclude that up to an extent with progression of age malignant lesions increase. Male to female ratio of mucosal lesions is 1.7:1 and of malignancy is 2.25:1. Narrow band imaging endoscopy helps us to identify best site of biopsy, helping in early diagnosis of disease and ultimately reducing morbidity and mortality of patient.</p>

Major Changes in Head and Neck Staging for 2018

2018 ◽  
pp. 505-514 ◽  
Author(s):  
William Lydiatt ◽  
Brian O’Sullivan ◽  
Snehal Patel
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Nasopharyngeal Carcinoma ◽  
Oral Cavity ◽  
Head And Neck ◽  
Depth Of Invasion ◽  
Immunohistochemical Stain ◽  
Extranodal Extension ◽  
Oral Cavity Cancers

Oncologists should be aware of three major modifications and additions to staging head and neck cancer that became effective in 2018. Oral cavity cancers have the addition of depth of invasion; oropharyngeal cancers (OPCs) are now distinguished by the immunohistochemical stain, p16, into those that are associated with high-risk human papillomavirus and those that are not; and all sites except nasopharyngeal carcinoma and high-risk human papillomavirus OPC will now include the important parameter of extranodal extension. The rationale and emerging data supporting these changes are discussed in this article and the accompanying oral presentation at the 2018 ASCO Annual Meeting.

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