Simple fabrication of multifunctional hyperbranched copolymer based on l-lysine and citric acid for co-delivery of anticancer drugs to breast cancer cells

In this paper we report development of three dimensional silicon microenvironments in order to test the morphological changes and adhesion properties of human breast cancer cells after treatment with different anticancer drugs such as Trichostatin A (TSA), suberoylanilide hydroxamic acid (SAHA) and Scriptaid. Our results indicate that the cancer cells reorganize their cytoskeleton structure after treatment with TSA and Scriptaid. However, SAHA does not change the behavior of the cells inside the three dimensional microstructures while TSA and Scriptaid evoked striking changes in the cells morphology. TSA and Scriptaid drugs cause the cells to stretch inside the isotropic microchambers to avoid contact with curved sidewalls in contrast to their originally rounded shape. The proposed microstructures can be used to evaluate mechanical properties and the pathological grade of various cancer cell lines after different conditions i.e. drug exposure.

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Effect of Distinct Anticancer Drugs on the Phosphorylation of p53 Protein at Serine 46 in Human MCF-7 Breast Cancer Cells

Annals of the New York Academy of Sciences ◽

10.1196/annals.1397.006 ◽

2007 ◽

Vol 1095 (1) ◽

pp. 45-52 ◽

Cited By ~ 4

Author(s):

J. WESIERSKA-GADEK ◽

M. GUEORGUIEVA ◽

I. HERBACEK ◽

C. RANFTLER

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Anticancer Drugs ◽

Breast Cancer Cells ◽

P53 Protein ◽

Mcf 7

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Suppression of αvβ6 downregulates P-glycoprotein and sensitizes multidrug-resistant breast cancer cells to anticancer drugs

Neoplasma ◽

10.4149/neo_2020_190604n486 ◽

2020 ◽

Vol 67 (02) ◽

pp. 379-388 ◽

Cited By ~ 1

Author(s):

Y.H. ZHANG ◽

Z.F. GAO ◽

G.H. DONG ◽

X. LI ◽

Y. WU ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Anticancer Drugs ◽

Breast Cancer Cells ◽

Multidrug Resistant ◽

P Glycoprotein

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A Review on Targeting Nanoparticles for Breast Cancer

Current Pharmaceutical Biotechnology ◽

10.2174/1389201020666190731130001 ◽

2019 ◽

Vol 20 (13) ◽

pp. 1087-1107 ◽

Cited By ~ 3

Author(s):

Hasanain Gomhor J. Alqaraghuli ◽

Soheila Kashanian ◽

Ronak Rafipour

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Cancer Cells ◽

Anticancer Drugs ◽

Targeted Drug Delivery ◽

Breast Cancer Cells ◽

Pharmaceutical Research ◽

Chemotherapeutic Agents ◽

Great Promise ◽

Targeted Drug

Chemotherapeutic agents have been used extensively in breast cancer remedy. However, most anticancer drugs cannot differentiate between cancer cells and normal cells, leading to toxic side effects. Also, the resulted drug resistance during chemotherapy reduces treatment efficacy. The development of targeted drug delivery offers great promise in breast cancer treatment both in clinical applications and in pharmaceutical research. Conjugation of nanocarriers with targeting ligands is an effective therapeutic strategy to treat cancer diseases. In this review, we focus on active targeting methods for breast cancer cells through the use of chemical ligands such as antibodies, peptides, aptamers, vitamins, hormones, and carbohydrates. Also, this review covers all information related to these targeting ligands, such as their subtypes, advantages, disadvantages, chemical modification methods with nanoparticles and recent published studies (from 2015 to present). We have discussed 28 different targeting methods utilized for targeted drug delivery to breast cancer cells with different nanocarriers delivering anticancer drugs to the tumors. These different targeting methods give researchers in the field of drug delivery all the information and techniques they need to develop modern drug delivery systems.

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