A new bioactive Schiff base ligands derived from propylazo-N-pyrimidin-2-yl-benzenesulfonamides Mn(II) and Cu(II) complexes: Synthesis, thermal and spectroscopic characterization biological studies and 3D modeling structures

2012 ◽  
Vol 97 ◽  
pp. 1172-1180 ◽  
Author(s):  
Abdelrazak M. Tawfik ◽  
Mosad A. El-ghamry ◽  
Samy M. Abu-El-Wafa ◽  
Naglaa M. Ahmed
Keyword(s):  
Schiff Base ◽  
3D Modeling ◽  
Spectroscopic Characterization ◽  
Schiff Base Ligands ◽  
Biological Studies

scholarly journals Synthesis, Spectroscopic Characterization and Biological Studies of Mn(II), Cu(II), Ni(II), Co(II) and Zn(II) Complexes with New Schiff Base of 2-((Pyrazine-2-ylimino)methyl)phenol

2021 ◽  
Vol 11 (19) ◽  
pp. 9067
Author(s):  
Hanan B. Howsaui ◽  
Abeer A. Sharfalddin ◽  
Magda H. Abdellattif ◽  
Amal S. Basaleh ◽  
Mostafa A. Hussien
Keyword(s):  
Schiff Base ◽  
Spectroscopic Characterization ◽  
Docking Studies ◽  
Spectroscopic Technique ◽  
Molar Ratio ◽  
Practical Result ◽  
Biological Studies ◽  
Elemental Analyses ◽  
Experimental Values ◽  
New Compounds

In the search for novel anticancer complex, transition metal complexes of Schiff base derived from 2-aminopyrazine and salicylaldehyde were successfully synthesized and characterized based on elemental analyses, spectroscopic and thermal analysis. The IR spectra showed the ligand is a tridentate chelator with O, N and N atoms. donor sites in the Zn(II), Co(II), Ni(II), and Mn(II) complexes. Contrary, it behaved a bidentate chelator in the Cu complex by O and N. Molar ratio data revealed that the ligand to metal ratio was 1:2 for Co(II) Cu(II) and Zn(II) while it was 1:1 for Mn(II) and Ni(II) complexes. The obtained complexes have the formulae [M(L)2] (where M = Co(II) and Zn(II), [M(L)Cl(2H2O)]·H2O (where M = Ni(II) and Mn(II) were octahedral geometry). The computational studies were performed by DFT calculations to compare the optimized geometries with the experimental values. The interaction of these complexes with calf thymus DNA (CT-DNA) was investigated by UV-Vis spectroscopic technique. Molecular docking studies were against three protein cancer to investigate the binding ability of the new compounds. The anticancer activity was studied with different cell lines and the IC50 of the Cu(II) complex for (HOP-62) showed a practical result. The LD50 values of Zn(II) and Co(II) complexes showed that they are non-toxic at doses up to 370 mg/kg.

Synthesis, Characterization and Biological Studies of Nickel ( Ii) and Zinc ( Ii) Complexes with Mono - and Di - Bromo Substituted Schiff Base Ligands

2020 ◽  
Author(s):  
Bussaba Pinchaipat ◽  
Teerawat Khudkham ◽  
Sutthida Wongsuwan ◽  
Ratanon Chotima ◽  
Kittipong Chainok ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligands ◽  
Biological Studies

scholarly journals SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL STUDIES OF 2-{[(2-HYDROXY-5-METHOXYPHENYL) METHYLIDENE] AMINO} NICOTINIC ACID AND ITS MANGANESE (II) COMPLEXES

2021 ◽  
Vol 46 (2) ◽  
Author(s):  
I. G. Osigbemhe ◽  
M. E. Khan ◽  
A. P. Oviawe ◽  
M.L Ugheoke
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complex ◽  
Nicotinic Acid ◽  
Elemental Analysis ◽  
Antimicrobial Agents ◽  
Spectroscopic Characterization ◽  
National Standards ◽  
Zone Of Inhibition ◽  
Biological Studies

Manganese(II) complexes of 2-{[(2-hydroxy-5-nitrophenyl) methylidene]amino} nicotinic acid derived from o-phenylenediamine and 5- nitrosalicaldehyde were synthesized and characterized by elemental analysis, using IR, 1HNMR, 13CNMR, and GCMS. They were screened against known disease causative microbes to establish their potentials as antimicrobial agents compared with national standards drugs. Results showed that, a Schiff base exhibited antimicrobial action against all the bacteria and most of the fungi with exception of Candidas. albicans isolate, which exhibited zero diameter zone of inhibition. It was also found that the synthesized Schiff base exhibited two digits purity range, implying that it was relatively stable. The metal complex was found to be more susceptible in overall biological activity due to the structural stability, showing their potency in pharmacognocy.

SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL STUDIES OF 2-{[(2-hydroxy-5-methoxyphenyl)methylidene]amino} nicotinic acid AND ITS Iron (II) COMPLEXES

2021 ◽  
Vol 5 (2) ◽  
pp. 477-488
Author(s):  
G. Osigbemhe ◽  
M. E. Khan ◽  
A. Olusegun ◽  
H. D. Kabiru
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complex ◽  
Nicotinic Acid ◽  
Antimicrobial Agents ◽  
Spectroscopic Characterization ◽  
National Standards ◽  
Zone Of Inhibition ◽  
Biological Studies ◽  
Uv Visible

Iron (II) complexes of 2-{[(2-hydroxy-5-methoxyphenyl) methylidene]amino} nicotinic acid derived from o-phenylenediamine and 5- methoxysalicaldehyde were synthesized and characterized by elemental analysis, using  UV-Visible, IR, 1HNMR, 13CNMR,  They were screened against known disease causative microbes to establish their effectiveness and efficacies as antimicrobial agents compared with national standards drugs, ampiclox and ketoconazole. Results showed that, the Schiff base exhibits antimicrobial action against all the bacteria and most of the fungi with exception of Candidas. albicans which exhibited naught diameter zone of inhibition. It was also found that the synthesized Schiff base exhibited two digits purity range, implying that it is relatively stable.  The metal complex was found to be more susceptible in overall biological activity than the Schiff base synthesized and studied due to their structural stability in relationship to its activity. This has opened another drug window for the remedy to human diseases caused by these microbes

Synthesis and Characterization of Palladium(II) Schiff Base and their Catalytic Activities for Heck Reaction

2012 ◽  
Vol 554-556 ◽  
pp. 736-740 ◽  
Author(s):  
Amalina Mohd Tajuddin ◽  
Hadariah Bahron ◽  
Karimah Kassim ◽  
Wan Nazihah Wan Ibrahim ◽  
Hoong Kun Fun
Keyword(s):  
Schiff Base ◽  
Coupling Reaction ◽  
Spectroscopic Characterization ◽  
Heck Coupling ◽  
Schiff Base Ligands ◽  
H Nmr ◽  
Catalytic Potential ◽  
Physico Chemical ◽  
Ft Ir

The syntheses, physico-chemical and spectroscopic characterization of ovan-type Schiff-base ligands (L1, L2) and their novel mononuclear Pd(II) complexes (PdL1, PdL2) are reported herein. Elemental analysis, FT-IR,1H NMR as well as magnetic susceptibility measurements characterised the compounds. The catalytic potential of the Pd(II) complexes for Heck coupling reaction were investigated and monitored using GC. It was observed that both Pd(II) complexes displayed properties of good catalysts for the reaction, indicated by 100% conversion of the starting materials to the subtituted alkene product after 6 hours of reaction time at 100°C in inert conditions. The catalytic activity was compared with the reaction without Pd(II) complexes.

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