SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL STUDIES OF 2-{[(2-hydroxy-5-methoxyphenyl)methylidene]amino} nicotinic acid AND ITS Iron (II) COMPLEXES

2021 ◽  
Vol 5 (2) ◽  
pp. 477-488
Author(s):  
G. Osigbemhe ◽  
M. E. Khan ◽  
A. Olusegun ◽  
H. D. Kabiru
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complex ◽  
Nicotinic Acid ◽  
Antimicrobial Agents ◽  
Spectroscopic Characterization ◽  
National Standards ◽  
Zone Of Inhibition ◽  
Biological Studies ◽  
Uv Visible

Iron (II) complexes of 2-{[(2-hydroxy-5-methoxyphenyl) methylidene]amino} nicotinic acid derived from o-phenylenediamine and 5- methoxysalicaldehyde were synthesized and characterized by elemental analysis, using  UV-Visible, IR, 1HNMR, 13CNMR,  They were screened against known disease causative microbes to establish their effectiveness and efficacies as antimicrobial agents compared with national standards drugs, ampiclox and ketoconazole. Results showed that, the Schiff base exhibits antimicrobial action against all the bacteria and most of the fungi with exception of Candidas. albicans which exhibited naught diameter zone of inhibition. It was also found that the synthesized Schiff base exhibited two digits purity range, implying that it is relatively stable.  The metal complex was found to be more susceptible in overall biological activity than the Schiff base synthesized and studied due to their structural stability in relationship to its activity. This has opened another drug window for the remedy to human diseases caused by these microbes

scholarly journals SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL STUDIES OF 2-{[(2-HYDROXY-5-METHOXYPHENYL) METHYLIDENE] AMINO} NICOTINIC ACID AND ITS MANGANESE (II) COMPLEXES

2021 ◽  
Vol 46 (2) ◽  
Author(s):  
I. G. Osigbemhe ◽  
M. E. Khan ◽  
A. P. Oviawe ◽  
M.L Ugheoke
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complex ◽  
Nicotinic Acid ◽  
Elemental Analysis ◽  
Antimicrobial Agents ◽  
Spectroscopic Characterization ◽  
National Standards ◽  
Zone Of Inhibition ◽  
Biological Studies

Manganese(II) complexes of 2-{[(2-hydroxy-5-nitrophenyl) methylidene]amino} nicotinic acid derived from o-phenylenediamine and 5- nitrosalicaldehyde were synthesized and characterized by elemental analysis, using IR, 1HNMR, 13CNMR, and GCMS. They were screened against known disease causative microbes to establish their potentials as antimicrobial agents compared with national standards drugs. Results showed that, a Schiff base exhibited antimicrobial action against all the bacteria and most of the fungi with exception of Candidas. albicans isolate, which exhibited zero diameter zone of inhibition. It was also found that the synthesized Schiff base exhibited two digits purity range, implying that it was relatively stable. The metal complex was found to be more susceptible in overall biological activity due to the structural stability, showing their potency in pharmacognocy.

scholarly journals Some Metal Ions Complexes Derived From Schiff Base Ligand with Anthranillic Acid: Preparation, Spectroscopic and Biological Studies

2020 ◽  
Vol 17 (1) ◽  
pp. 0099
Author(s):  
Lekaa khalid Karem
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Magnetic Moment ◽  
Primary Amine ◽  
Molar Conductivity ◽  
Spectroscopic Methods ◽  
Geometrical Shape ◽  
Biological Studies ◽  
Different Types ◽  
Uv Visible

This search includes the preparation of Schiff base ligand (SB) from condensation primary amine with vanillin. The new ligand was diagnosed by spectroscopic methods as Mass, NMR, CHN and FTIR. Ligand complexes were mixed from new (SB) and Anthranillic acid (A) with five metal (II) chlorides. The preparation and diagnosis were conducted by FTIR, CHN, UV-visible, molar conductivity, atomic absorption and magnetic moment. The octahedral geometrical shape of the complexes was proposed. The ligands and their new complexes were screened with two different types of bacteria.

scholarly journals Zr(IV), La(III), and Ce(IV) Chelates with 2-[(4-[(Z)-1-(2-Hydroxyphenyl)ethylidene]aminobutyl)-ethanimidoyl]phenol: Synthesis, Spectroscopic Characterization, and Antimicrobial Studies

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
M. M. El-ajaily ◽  
H. A. Abdullah ◽  
Ahmed Al-janga ◽  
E. E. Saad ◽  
A. A. Maihub
Keyword(s):  
Schiff Base ◽  
Spectral Data ◽  
Schiff Base Ligand ◽  
Active Sites ◽  
Antimicrobial Agents ◽  
Spectroscopic Characterization ◽  
Metal Chelates ◽  
Molar Ratio ◽  
Bacterial Strains ◽  
Activity Data

La(III), Zr(IV), and Ce(IV) chelates of 2-[(4-[(Z)-1-(2-hydroxyphenyl)ethylidene]aminobutyl)-ethanimidoyl]phenol were synthesized and characterized by using several physical techniques. The Schiff base was obtained by refluxing of o-hydroxyacetophenone with 1,4-butanediamine in 2 : 1 molar ratio. The CHN elemental analysis results showed the formation of the Schiff base and the chelates has been found to be in 1 : 1 [M : L] ratio. The molar conductance measurements revealed that all the chelates are nonelectrolytes. Structural elucidations of the ligand and its chelates were based on compatible analytical and spectroscopic evidences. The infrared spectral data revealed that the Schiff base coordinates to the metal ions through active sites which are –OH and –C=N groups. According to the electronic spectral data, an octahedral geometry was proposed for the chelates. The synthesized ligand and its metal chelates were screened for their antimicrobial activity against two Gram negative (Escherichia coli, Salmonella kentucky) and two Gram positive (Lactobacillus fermentum, Streptococcus faecalis) bacterial strains, unicellular fungi (Fusarium solani), and filamentous fungi (Aspergillus niger). The activity data showed that the metal chelates have antibacterial and antifungal activity more than the parent Schiff base ligand against one or more bacterial or fungi species. The results also indicated that the metal chelates are higher sensitive antimicrobial agents as compared to the Schiff base ligand.

scholarly journals Synthesis, Spectroscopic Characterization and Biological Studies of Mn(II), Cu(II), Ni(II), Co(II) and Zn(II) Complexes with New Schiff Base of 2-((Pyrazine-2-ylimino)methyl)phenol

2021 ◽  
Vol 11 (19) ◽  
pp. 9067
Author(s):  
Hanan B. Howsaui ◽  
Abeer A. Sharfalddin ◽  
Magda H. Abdellattif ◽  
Amal S. Basaleh ◽  
Mostafa A. Hussien
Keyword(s):  
Schiff Base ◽  
Spectroscopic Characterization ◽  
Docking Studies ◽  
Spectroscopic Technique ◽  
Molar Ratio ◽  
Practical Result ◽  
Biological Studies ◽  
Elemental Analyses ◽  
Experimental Values ◽  
New Compounds

In the search for novel anticancer complex, transition metal complexes of Schiff base derived from 2-aminopyrazine and salicylaldehyde were successfully synthesized and characterized based on elemental analyses, spectroscopic and thermal analysis. The IR spectra showed the ligand is a tridentate chelator with O, N and N atoms. donor sites in the Zn(II), Co(II), Ni(II), and Mn(II) complexes. Contrary, it behaved a bidentate chelator in the Cu complex by O and N. Molar ratio data revealed that the ligand to metal ratio was 1:2 for Co(II) Cu(II) and Zn(II) while it was 1:1 for Mn(II) and Ni(II) complexes. The obtained complexes have the formulae [M(L)2] (where M = Co(II) and Zn(II), [M(L)Cl(2H2O)]·H2O (where M = Ni(II) and Mn(II) were octahedral geometry). The computational studies were performed by DFT calculations to compare the optimized geometries with the experimental values. The interaction of these complexes with calf thymus DNA (CT-DNA) was investigated by UV-Vis spectroscopic technique. Molecular docking studies were against three protein cancer to investigate the binding ability of the new compounds. The anticancer activity was studied with different cell lines and the IC50 of the Cu(II) complex for (HOP-62) showed a practical result. The LD50 values of Zn(II) and Co(II) complexes showed that they are non-toxic at doses up to 370 mg/kg.

scholarly journals REVIEW: A RECENT REVIEW IN APPLICATIONS OF HETEROCYCLIC COMPOUNDS AS ANTIMICROBIAL AGENT

2018 ◽  
Vol 11 (12) ◽  
pp. 66
Author(s):  
Mohanambal D ◽  
Sridevi G ◽  
Arul Antony S ◽  
Angayarkani R
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Fine Structure ◽  
Multidrug Resistance ◽  
Antimicrobial Agent ◽  
Metal Complex ◽  
Heterocyclic Compounds ◽  
Antimicrobial Agents ◽  
Biological Action ◽  
Medicinal Drugs

A wide development in the field of multidrug resistance in antimicrobial activity which enhance the search for development of new medicinal drugs with high potential. Schiff base heterocyclic metal complex with imine moiety, act as important antimicrobial agents due to their versatile properties such as chelation, adaptability of fine structure for a specific biological action, and chemotheraptic drugs. Schiff base compounds derived from various heterocyclic platforms have been competently reviewed. 

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