scholarly journals Flavonoids from Rhamnus alaternus L. (Rhamnaceae): Kaempferol 3-O-β-isorhamninoside and rhamnocitrin 3-O-β-isorhamninoside protect against DNA damage in human lymphoblastoid cell and enhance antioxidant activity

2012 ◽  
Vol 80 ◽  
pp. 57-62 ◽  
Author(s):  
Wissem Bhouri ◽  
Jihed Boubaker ◽  
Soumaya Kilani ◽  
Kamel Ghedira ◽  
Leila Chekir-Ghedira
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Human Lymphoblastoid Cell ◽  
Rhamnus Alaternus

scholarly journals Protective Activity of C-Geranylflavonoid Analogs from Paulownia tomentosa against DNA Damage in 137Cs Irradiated AHH-1Cells

2014 ◽  
Vol 9 (9) ◽  
pp. 1934578X1400900
Author(s):  
Hyung-In Moon ◽  
Min Ho Jeong ◽  
Wol Soon Jo
Keyword(s):  
Dna Damage ◽  
Protective Effects ◽  
Strand Breaks ◽  
Human Lymphoblastoid Cell ◽  
Wide Range ◽  
Radiation Induced ◽  
Anti Oxidant ◽  
Dna Strand ◽  
Cellular Dna

Radiotherapy is an important form of treatment for a wide range of cancers, but it can damage DNA and cause adverse effects. We investigated if the diplacone analogs of P. tomentosa were radio-protective in a human lymphoblastoid cell line (AHH-1). Four geranylated flavonoids, diplacone, 3′- O-methyl-5′-hydroxydiplacone, 3′- O-methyl-5′- O-methyldiplacone and 3′- O-methyldiplacol, were tested for their antioxidant and radio-protective effects. Diplacone analogs effectively scavenged free radicals and inhibited radiation-induced DNA strand breaks in vitro. They significantly decreased levels of reactive oxygen species and cellular DNA damage in 2 Gy-irradiated AHH-1 cells. Glutathione levels and superoxide dismutase activity in irradiated AHH-1 cells increased significantly after treatment with these analogs. The enhanced biological anti-oxidant activity and radioprotective activity of diplacone analogs maintained the survival of irradiated AHH-1 cells in a clonogenic assay. These data suggest that diplacone analogs may protect healthy tissue surrounding tumor cells during radiotherapy to ensure better control of radiotherapy and allow higher doses of radiotherapy to be employed.

Antioxidant activity in sugarcane juice and its protective role against radiation induced DNA damage

2008 ◽  
Vol 106 (3) ◽  
pp. 1154-1160 ◽  
Author(s):  
U.S. Kadam ◽  
S.B. Ghosh ◽  
Strayo De ◽  
P. Suprasanna ◽  
T.P.A. Devasagayam ◽  
...  
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Protective Role ◽  
Sugarcane Juice ◽  
Radiation Induced

Antioxidant Activity of Indigo and its Preventive Effect against Ethanol-Induced DNA Damage in Rat Gastric Mucosa

Planta Medica ◽  
2007 ◽  
Vol 73 (12) ◽  
pp. 1241-1246 ◽  
Author(s):  
Elisangela Farias-Silva ◽  
Maíra Cola ◽  
Tamara Calvo ◽  
Victor Barbastefano ◽  
Anderson Ferreira ◽  
...  
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Gastric Mucosa ◽  
Preventive Effect ◽  
Rat Gastric Mucosa

Main nutrients, phenolics, antioxidant activity, DNA damage protective effect and microstructure of Sphallerocarpus gracilis root at different harvest time

2011 ◽  
Vol 127 (2) ◽  
pp. 615-622 ◽  
Author(s):  
Chun-yan Gao ◽  
Yue-hong Lu ◽  
Cheng-rui Tian ◽  
Jian-guo Xu ◽  
Xiao-peng Guo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Protective Effect ◽  
Harvest Time ◽  
Dna Damage Protective

Leaf and root extracts of Moricandia arvensis protect against DNA damage in human lymphoblast cell K562 and enhance antioxidant activity

2010 ◽  
Vol 30 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Ines Skandrani ◽  
Jihed Boubaker ◽  
Ines Bouhlel ◽  
Ilef Limem ◽  
Kamel Ghedira ◽  
...  
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Root Extracts ◽  
Human Lymphoblast ◽  
Moricandia Arvensis

Aqueous Extract of Crataegus azarolus Protects Against DNA Damage in Human Lymphoblast Cell K562 and Enhances Antioxidant Activity

2013 ◽  
Vol 172 (4) ◽  
pp. 2266-2275 ◽  
Author(s):  
Nadia Mustapha ◽  
Inès Bouhlel ◽  
Fadwa Chaabane ◽  
Imèn Mokdad Bzéouich ◽  
Kamel Ghedira ◽  
...  
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Human Lymphoblast

Enhanced total phenolic and isoflavone aglycone content, antioxidant activity and DNA damage protection of soybeans processed by solid state fermentation with Rhizopus oligosporus RT-3

RSC Advances ◽  
2016 ◽  
Vol 6 (35) ◽  
pp. 29741-29756 ◽  
Author(s):  
Yu Xiao ◽  
Juan Fan ◽  
Yulian Chen ◽  
Xin Rui ◽  
Qiuqin Zhang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Solid State ◽  
Solid State Fermentation ◽  
Total Phenolic ◽  
Rhizopus Oligosporus ◽  
Short Time ◽  
Dna Damage Protection ◽  
Damage Protection

In this study,Rhizopus oligosporusRT-3, which was first isolated in our group, was used for solid state fermentation of soybeans (R. oligosporus-fermented soybeans, RFS) in a short time (22 h).

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