Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia

2008 ◽  
Vol 101 (1-3) ◽  
pp. 58-66 ◽  
Author(s):  
Yumiko Ikeda ◽  
Noriaki Yahata ◽  
Itsuo Ito ◽  
Masatoshi Nagano ◽  
Tomoko Toyota ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Neurotrophic Factor ◽  
Chronic Schizophrenia ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Epidermal Growth ◽  
Low Serum

scholarly journals Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

2020 ◽  
Vol 21 (7) ◽  
pp. 2577 ◽  
Author(s):  
Cuizhu Wang ◽  
Yuze Yuan ◽  
He Pan ◽  
Alan Chen-Yu Hsu ◽  
Jinluan Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acetic Acid ◽  
Gastric Ulcer ◽  
Growth Factor ◽  
Gastric Mucosa ◽  
Epidermal Growth Factor ◽  
Serum Levels ◽  
Gastroprotective Effect ◽  
Epidermal Growth ◽  
Oxide Synthase

Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the Panax genus, possesses good anti-inflammatory activity. The study aimed to investigate the gastroprotective effect of ocotillol on acetic acid-induced GU rats. The serum levels of endothelin-1 (ET-1) and nitric oxide (NO), the gastric mucosa levels of epidermal growth factor, superoxide dismutase and NO were assessed. Hematoxylin and eosin staining of gastric mucosa for pathological changes and immunohistochemical staining of ET-1, epidermal growth factor receptors and inducible nitric oxide synthase were evaluated. A UPLC-QTOF-MS-based serum metabolomics approach was applied to explore the latent mechanism. A total of 21 potential metabolites involved in 7 metabolic pathways were identified. The study helps us to understand the pathogenesis of GU and to provide a potential natural anti-ulcer agent.

Serum levels of insulin-like growth factor-1 and brain-derived neurotrophic factor as potential recovery biomarkers in stroke

2019 ◽  
Vol 41 (4) ◽  
pp. 354-363 ◽  
Author(s):  
Michael King ◽  
Liam P. Kelly ◽  
Elizabeth M. Wallack ◽  
S. M. Mahmudul Hasan ◽  
Megan C. Kirkland ◽  
...  
Keyword(s):  
Growth Factor ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Insulin Like Growth Factor
Sign in / Sign up

Export Citation Format

Share Document