Psychosis risk screening in clinical high-risk adolescents: A longitudinal investigation using the Child Behavior Checklist

Introduction: Exposure to cumulative environmental risk factors across development has been linked to a host of adverse health/functional outcomes. This perspective incorporating information regarding exposure at differing developmental periods is lacking in research surrounding individuals at Clinical High Risk (CHR) for developing a psychotic disorder. Methods: CHR individuals (n = 35) and healthy volunteers (n = 28) completed structured clinical interviews as well as our group’s newly developed Individual and Structural Exposure to Stress in Psychosis-risk-states (ISESP) interview. Lifetime cumulative scores were calculated, and severity of stress was reported for multiple developmental periods/ages. Group differences were tested, and associations with current symptom domains were examined. Results: Significant group differences were not observed for lifetime cumulative events, though CHR trended toward endorsing more events and greater stress severity. For stress severity across development, there were trending group differences for the 11–13 age range, and significant group differences for the 14–18 age range; notably, comparisons for earlier time points did not approach statistical significance. Associations between negative symptoms and cumulative severity of exposure were observed. Discussion: Results suggest exploring exposure to cumulative environmental risk factors/stressors and stress severity across developmental periods is generally informative and possibly specifically so for predictive models and diathesis-stress psychosis risk conceptualizations.

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Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity

Biological Psychiatry ◽

10.1016/j.biopsych.2013.07.038 ◽

2014 ◽

Vol 75 (6) ◽

pp. 459-469 ◽

Cited By ~ 126

Author(s):

Veronica B. Perez ◽

Scott W. Woods ◽

Brian J. Roach ◽

Judith M. Ford ◽

Thomas H. McGlashan ◽

...

Keyword(s):

High Risk ◽

Auditory Processing ◽

Mismatch Negativity ◽

Clinical High Risk ◽

High Risk Patients ◽

Psychosis Risk ◽

Risk Patients ◽

Processing Deficits

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Childhood behaviour, psychotic symptoms and psychosis onset in young people at high risk of schizophrenia: early findings from the Edinburgh High Risk Study

Psychological Medicine ◽

10.1017/s0033291701004779 ◽

2002 ◽

Vol 32 (1) ◽

pp. 173-179 ◽

Cited By ~ 50

Author(s):

P. M. MILLER ◽

M. BYRNE ◽

A. HODGES ◽

S. M. LAWRIE ◽

E. C. JOHNSTONE

Keyword(s):

At Risk ◽

High Risk ◽

Young People ◽

Child Behavior ◽

Aggressive Behaviour ◽

Child Behavior Checklist ◽

Somatic Symptoms ◽

Study Groups ◽

Psychotic Symptoms ◽

Neurodevelopmental Abnormalities

Background. Several studies suggest that many patients with schizophrenia have pre-morbid neurodevelopmental abnormalities. This study examines how behavioural abnormalities are associated with mild psychotic symptoms and later schizophrenic illness.Methods. Maternal ratings on the Child Behavior Checklist (CBCL) of the early behaviour of 155 subjects were obtained at entry to the Edinburgh study of people at high risk of schizophrenia. These maternal ratings were compared in those with and without psychotic symptoms and used to predict the later onset of psychosis.Results. The CBCL syndrome scores for the children prior to age 13 did not distinguish any of the study groups at entry to the study. In the ratings made for the subjects when aged from 13 to 16, delinquent behaviour and ‘other problems’ were weakly associated with these symptoms. However, with the exception of somatic symptoms and thought problems, the age 13–16 scales were significant predictors of later schizophrenic illness. This was true also for some of the ratings prior to age 13.Conclusions. Various behaviours, in particular, withdrawn and delinquent–aggressive behaviour in adolescents at risk of schizophrenia may predict later onset of the illness. These behaviours, however, are far less predictive of isolated psychotic symptoms prior to psychosis onset.

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155. Tobacco Use and Psychosis Risk in Persons at Clinical High Risk

Schizophrenia Bulletin ◽

10.1093/schbul/sbx021.213 ◽

2017 ◽

Vol 43 (suppl_1) ◽

pp. S80-S80 ◽

Cited By ~ 1

Author(s):

Heather Burrell ◽

Michael Lawson ◽

Jean Addington ◽

Carrie Bearden ◽

Kristin Cadenhead ◽

...

Keyword(s):

High Risk ◽

Tobacco Use ◽

Clinical High Risk ◽

Psychosis Risk

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T37. PREPULSE INHIBITION IN UNAFFECTED SIBLINGS OF SCHIZOPHRENIA AND CLINICAL-HIGH RISK WITHOUT FAMILY HISTORY OF PSYCHOSIS

Schizophrenia Bulletin ◽

10.1093/schbul/sbaa029.597 ◽

2020 ◽

Vol 46 (Supplement_1) ◽

pp. S245-S246

Author(s):

Mao Zhen ◽

Qijing Bo ◽

Qing Tian ◽

Fang Dong ◽

Xianbin Li ◽

...

Keyword(s):

Family History ◽

High Risk ◽

Prepulse Inhibition ◽

Spatial Separation ◽

Structured Interview ◽

Clinical High Risk ◽

Priority Effect ◽

Stimulus Interval ◽

Psychosis Risk ◽

History Of

Abstract Background It is reported that prepulse inhibition (PPI) deficiency of startle reflex in schizophrenia is associated with positive symptoms and is hereditary. In this study, the perceived spatial separation (PSS) induced-prepulse inhibition paradigm based on the priority effect effectively was used to explore PPI levels of genetically high-risk (GHR) of schizophrenia and clinical high risk (CHR) without family history of psychosis Methods We examined startle magnitude and PPI in38 CHR (No family history of psychosis), 28 GHR (Siblings or children of schizophrenia), and 44 healthy controls (HC). Modified acoustic PPI paradigm included PSS-PPI and perceived spatial co-location PPI (PSC-PPI) with inter-stimulus interval (ISI) of 60 or 120ms. The Structured Interview for Psychosis risk Syndromes (SIPS) and MATRICS Consensus Cognitive Battery (MCCB) was used to measure psychotic symptom and neuropsychological state of individuals Results Using gender, age, and smoking as covariates, Covariance analysis for modified PPI level results revealed that there were significant differences in PSSPPI60 (F = 6.25, p = 0.03) and PSSPI120 (F = 6.57, p = 0.03) paradigm between the three groups. Compared with HC, PSSPPI paradigm detected PPI defects of CHR individuals at 60ms ISI (F = 14.25, p ＜0.001) and 120ms ISI (F = 14.01, p ＜0.001). PPI deficiency was not detected in GHR individuals. PPI level in both groups were unrelated to demographics, clinical characteristics, and cognition. Using GLM analysis, the interaction between grouping and experimental paradigm had no significant effect on PPI level at 60ms (F = 1.88, P = 0.16) and 120ms (Z = 1.66, P = 0.19). Discussion It seems that mere heritability of psychosis is not enough to produce PPI defects, which may be related to the progression of psychosis

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S105. VALIDATING THE PREDICTIVE ACCURACY OF THE NAPLS-2 PSYCHOSIS RISK CALCULATOR IN A CLINICAL HIGH-RISK SAMPLE FROM THE SHARP (SHANGHAI AT RISK FOR PSYCHOSIS) PROGRAM

Schizophrenia Bulletin ◽

10.1093/schbul/sby018.892 ◽

2018 ◽

Vol 44 (suppl_1) ◽

pp. S366-S366

Author(s):

TianHong Zhang ◽

HuiJun Li ◽

LiHua Xu ◽

YingYing Tang ◽

HuiRu Cui ◽

...

Keyword(s):

At Risk ◽

High Risk ◽

Predictive Accuracy ◽

Clinical High Risk ◽

Risk Calculator ◽

Psychosis Risk

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Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk

JAMA Psychiatry ◽

10.1001/jamapsychiatry.2015.2324 ◽

2016 ◽

Vol 73 (2) ◽

pp. 113 ◽

Cited By ~ 198

Author(s):

Paolo Fusar-Poli ◽

Marco Cappucciati ◽

Stefan Borgwardt ◽

Scott W. Woods ◽

Jean Addington ◽

...

Keyword(s):

High Risk ◽

Clinical High Risk ◽

Psychosis Risk

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Alterations in Emotional Diversity Correspond With Increased Severity of Attenuated Positive and Negative Symptoms in the Clinical High-Risk Syndrome

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.755027 ◽

2021 ◽

Vol 12 ◽

Author(s):

Zachary Anderson ◽

Tina Gupta ◽

William Revelle ◽

Claudia M. Haase ◽

Vijay A. Mittal

Keyword(s):

High Risk ◽

Negative Symptoms ◽

Medication Use ◽

Structured Interview ◽

Clinical High Risk ◽

Future Studies ◽

Clinical Interviews ◽

Clinical Correlates ◽

Psychosis Risk ◽

Positive And Negative Symptoms

Background: Alterations in emotional functioning are a key feature of psychosis and are present in individuals with a clinical high-risk (CHR) syndrome. However, little is known about alterations in emotional diversity (i.e., the variety and relative abundance of emotions that humans experience) and clinical correlates in this population.Methods: Individuals meeting criteria for a CHR syndrome (N = 47) and matched healthy controls (HC) (N = 58) completed the modified Differential Emotions Scale (used to derive scores of total, positive, and negative emotional diversity) and clinical interviews (i.e., Structured Interview for Psychosis-Risk Syndromes).Results: Findings showed that the CHR group experienced lower levels of positive emotional diversity compared to HCs. Among the CHR individuals, lower levels of positive and higher levels of negative emotional diversity were associated with more severe attenuated positive and negative symptoms. Analyses controlled for mean levels of emotion and current antipsychotic medication use.Discussion: Results demonstrate that altered emotional diversity (in particular lower levels of positive and higher levels of negative emotional diversity) is a clinically relevant marker in CHR individuals, above and beyond alterations in mean levels of emotional experiences. Future studies may probe sources, downstream consequences, and potential modifiability of decreased emotional diversity in individuals at CHR.

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