scholarly journals The lyophilized aqueous leaf extract of Moringa oleifera blunts streptozocin-induced diabetes in rats through upregulation of GLUT 4 signaling pathway and anti-oxidant effect

2020 ◽  
Vol 10 ◽  
pp. e00619
Author(s):  
Adeolu Alex Adedapo ◽  
Iyanuoluwa Omolola Ogunmiluyi ◽  
Olufunke Olubunmi Falayi ◽  
Blessing Seun Ogunpolu ◽  
Ademola Adetokunbo Oyagbemi ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Glut 4 ◽  
Anti Oxidant ◽  
Aqueous Leaf Extract ◽  
Oxidant Effect

Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals

2015 ◽  
Vol 26 (5) ◽  
Author(s):  
Adeolu Alex Adedapo ◽  
Olufunke Olubunmi Falayi ◽  
Ademola Adetokunbo Oyagbemi
Keyword(s):  
Leaf Extract ◽  
Moringa Oleifera ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Laboratory Animals ◽  
Phytochemical Analysis ◽  
Writhing Test ◽  
Analgesic Effects ◽  
Anti Oxidant ◽  
Anti Inflammatory

AbstractThe commercially processedThe phytochemical analysis showed that the extract contained flavonoids, terpenoids, glycosides, tannins and saponins. In the acetic acid-induced writhing test, the extract significantly reduced the number of writhes at 100 and 200 mg/kg but not so much at 50 mg/kg. In the formalin-induced paw lick test, the effect was similar to that of the acetic writhing test. The analgesic effects were comparable to that of indomethacin used at 10 mg/kg. In the anti-inflammatory test, the extract reduced the formation of oedema especially at a dose of 200 mg/kg. In the anti-oxidant test, the extract was found to possess a free radical-scavenging property and is concentration related.The use of this extract for medicinal and nutritional purposes may have thus been justified; however, caution must be exercised in its use to prevent the toxic effect.

scholarly journals Antihelminthic Activity in Aqueous Leaf Extract of Moringa oleifera Lam.

2018 ◽  
Vol 10 (03) ◽  
Author(s):  
Anitha R ◽  
Sahaya Kalaivani
Keyword(s):  
Aqueous Extract ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Condensed Tannin ◽  
Death Time ◽  
Aqueous Leaf Extract ◽  
Round Worm ◽  
Synthetic Drug ◽  
Moringa Oleifera Lam

The objective of the study is to evaluate the antihelminthic property of Moringa oleifera aqueous leaf extract by studying the paralysis and mortality time of Tubiflex tubiflex (blood worm). The aqueous extract at 200mg/ml exhibited paralysis time of 1 minute and death time of 2 minutes which was on par with synthetic drug Albendazole at 20mg/ml. Crude condensed tannin paralysed T.tubiflex at 60 seconds with mortality time of 9 minutes at 1mg/ml. T.tubiflex was selected for the study since they share a similar anatomical and physiological aspects with the intestinal round worm. The study indicated that T.tubiflex was inhibited effectively by condensed tannin in Moringa oleifera aqueous leaf extract and perhaps might be more effective on the round worms as well, since it is consumed as vegetable for its nutritive and medicinal values in tropical and subtropical regions.

Involvement of YAP/TAZ Signaling Pathway in Anti-obesity Activity of Moringa oleifera Leaf Extract

2021 ◽  
Vol 17 ◽  
Author(s):  
Titing Nurhayati ◽  
Anton ◽  
Iwan Setiawan ◽  
Vita Murniati Tarawan ◽  
Ronny Lesmana
Keyword(s):  
Herbal Medicine ◽  
Signaling Pathway ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Molecular Mechanisms ◽  
Therapeutic Agent ◽  
Efficacy And Safety ◽  
Main Principle ◽  
Experimental Researches ◽  
Reducing Energy

Introduction: Obesity has taken world concern since it has become a pandemic chronic disease. The main principle of obesity treatment is regulating energy balance by reducing energy intake and increasing energy expenditure. These target mechanisms become the point attention in herbal medicine studies. Several molecular mechanism of actions conducted by Moringa oleifera leaf extract (MLE) have been studied in many experimental researches. Objective: In this mini review, we encompass the mechanisms of MLE in demonstrating the anti-obesity activity, including the potential involvement of YAP/TAZ activity. Methods: Several major electronic databases including PubMed, Google Scholar, and Scopus were engaged in conceiving articles. The period was between August 2011 and August 2020. Results: From 18 established literatures, we demonstrated the anti-obesity activity of MLE in detail. Several citations accompanied the results of these researched-based studies to explain and illustrate the molecular mechanisms, including YAP/TAZ signaling pathway. Conclusion: MLE through its phytochemistry contents shows significant benefits on herbal medicine, especially the anti-obesity activity. MLE potentially contributes to modify the lipid metabolism in YAP/TAZ pathway. However, the study demonstrating this involvement has still not yet published. In the future, more exploration may provide hope for its efficacy and safety as the therapeutic agent of obesity.

Haematological and anti-oxidant changes associated with chloroquine resistance reversal by leaf extract of Moringa oleifera Lam

2016 ◽  
Vol 37 (2) ◽  
pp. 188
Author(s):  
S.S. Ogundapo ◽  
L.U.S. Ezeanyika ◽  
P.N. Uzoegwu ◽  
O.T. Soniran ◽  
C.A. Okpani ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Moringa Oleifera ◽  
Chloroquine Resistance ◽  
Resistance Reversal ◽  
Anti Oxidant

scholarly journals The Immuno-modulatory and Thrombocytopaenic Effects of the Varying Concentrations of the Aqueous Leaf Extract of Moringa Oleifera in Male Albino Wistar Rats

2019 ◽  
pp. 1-8
Author(s):  
Ojeka Sunday Ogbu ◽  
Zabbey Victor Zigabelbari
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Folk Medicine ◽  
Control Group ◽  
Distribution Width ◽  
Treatment Groups ◽  
Immature Platelet Fraction ◽  
Group A ◽  
Aqueous Leaf Extract

Introduction: Moringa oleifera and related species are commonly used in folk medicine for various human diseases. Aim: The study was undertaken to establish the thrombocytopenic effect of the aqueous leaf extract of moringa oleifera and to find the utilization of platelet parameters in determining the cause of the thrombocytopenia. Methodology: Fresh leaves of moringa were dried and extracted with water. Thirty (30) male albino Wistar rats, weighing between 150-250 g, which were kept under uniform laboratory conditions, were randomly divided into five (5) groups (A-E), based on their weights. The control group (group A) was orally given 0.5 ml of distilled water while the treatment groups (groups B to E) were orally given 250 mg/kg, 450 mg/kg,650 mg/kg and 850 mg/kg body weight respectively of the extract, once a day, for 56days and then sacrificed. At the end of the administration, blood samples were collected from each rat and examined for platelet indices. The effects of treatment with aqueous leaf extract of moringa oleifera on the platelet parameters were compared with the control group. Result: The rats treated with the extract, showed a decrease in platelet count and platelet crit while there was a significant increase in the platelet distribution width, mean platelet volume and immature platelet fraction, concerning the control. Conclusion: The aqueous leaf extract of moringa oleifera is therefore shown to modulate the immune system and cause thrombocytopaenia, through platelet destruction.

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