scholarly journals Ananas comosus and Citrus sinensis peels ameliorate CCl4-induced liver injury in Wistar rats

2021 ◽  
pp. e01026
Author(s):  
Henrietta Chisom Unanma ◽  
Emeka Godwin Anaduaka ◽  
Nene Orizu Uchendu ◽  
Chidimma Pamela Ononiwu ◽  
Victor Nwadiogbu Ogugua
Keyword(s):  
Liver Injury ◽  
Citrus Sinensis ◽  
Wistar Rats ◽  
Ananas Comosus

scholarly journals Hepatoprotective Effect of Citrus Sinensis Peel Extract Against Isoniazid and Rifampicin-induced Liver Injury in Wistar Rats

2019 ◽  
Vol 24 (3) ◽  
pp. 197
Author(s):  
Edward Kosasih ◽  
Linda Chiuman ◽  
I Nyoman Ehrich Lister ◽  
Edy Fachrial
Keyword(s):  
Liver Injury ◽  
Citrus Sinensis ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Ethanolic Extract ◽  
Hepatoprotective Effect ◽  
Control Groups ◽  
Male Wistar Rats ◽  
The Rich ◽  
Peel Extract

Tuberculosis (TB) is one of the leading causes of death in developing countries. One of the problems in controlling TB disease is that most anti-tuberculosis drugs are hepatotoxic. Citrus sinensis peel extract is the rich source of secondary metabolites with high potential effectiveness as an antioxidant. In the present study, we evaluate the hepatoprotective effect of Citrus sinensis peel ethanolic extract (CSPEE) on isoniazid and rifampicin-induced liver injury in Wistar rats. Twenty five adult male Wistar rats were divided into 5 groups of 5 each : control,  (INH+RIF) (50 mg/kg bw once a day for 14 days), (INH+RIF) + various dose of CSPEE (300, 450, 600 mg/kg bw).  CSPEE was given orally once a day for 14 days followed by administration of INH + RIF suspension. The measurement of serum ALT and AST were carried out on the 15th day. Histopathologic examination of the liver was also performed. The Serum ALT and AST of the rats that induced with INH + RIF were increased significantly (P<0.001) compare to those of control groups, and the histopathologic slides showed steatosis, vacuolation and necrosis of hepatic cells. The serum ALT and AST in groups treated with CSPEE were not significantly different (p>0.05) with those of control groups. The serum ALT and AST and histopathological examination of the liver of the group that administered 600 mg/kg CSPEE were closest to normal rats. Citrus sinensis peel extract exhibits hepatoprotective effect on liver injury induced with INH + RIF in Wistar rats.

scholarly journals Heart structure, serum cholesterol, and adiposity of rats treated with a hypercaloric diet: effectiveness of Citrus sinensis (L.) Osbeck and swimming

2020 ◽  
Vol 21 ◽  
Author(s):  
Beatriz Almeida Rodrigues ◽  
Gabrielle Queiroz Vacari ◽  
Fabiana Cirino dos Santos ◽  
Felipe Perissini ◽  
Matheus Nobile ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Herbal Medicine ◽  
Citrus Sinensis ◽  
Wistar Rats ◽  
Muscle Fibers ◽  
Abdominal Fat ◽  
Tukey Test ◽  
Cardiac Muscle Fibers ◽  
The Right ◽  
Hypercaloric Diet

Abstract This study evaluated the effects of the herbal medicine red orange (Citrus sinensis (L.) Osbeck) and swimming for 84 days on the animal, heart, and abdominal fat weight and the histomorphometric aspects of heart and total cholesterol of Wistar rats. The rats were divided into seven experimental groups of 12 animals each, consisting of a normocaloric diet (Dn), hypercaloric diet (Dh), normocaloric diet and herbal medicine (DnH), hypercaloric diet and herbal medicine (DhH), normocaloric diet and swimming (DnS), hypercaloric diet and swimming (DhS), and hypercaloric diet, swimming, and herbal medicine (DhSH). The data were analyzed statistically by the Tukey test and considered significant when p<0.05. Groups treated with the normocaloric diet had lower abdominal fat weight. The normocaloric diet and herbal medicine (DnH) provided the smallest thickness of the right ventricle. The hypercaloric diet (Dh) reduced the number of cardiomyocytes and the perimeter of cardiac muscle fibers. Swimming and the red orange extract acted synergistically by reducing the deleterious effects of the hypercaloric diet and increasing the thickness of the cardiac chambers and the number of cardiomyocytes. Only the supplementation with the red orange extract did not reduce abdominal fat in rats treated with a hypercaloric diet. Therefore, red orange alone did not promote beneficial changes in the studied data, but its association with swimming increased the number of cardiomyocytes and thickness of muscle fibers, which could contribute to preventing cardiovascular diseases and maintaining health, as well as the regular swimming and a normocaloric diet, which provided less adiposity.

scholarly journals Hepatoprotector effects of press needle acupuncture of GB34 and BL18 against isoniazid and rifampicin induced liver injury in Wistar rats

2018 ◽  
Vol 1073 ◽  
pp. 062029
Author(s):  
A M Jufriansjah ◽  
C Simadibrata ◽  
A Srilestari ◽  
E H Purwaningsih ◽  
M Stephanie
Keyword(s):  
Liver Injury ◽  
Wistar Rats ◽  
Needle Acupuncture

scholarly journals Mitigative effects of Moringa oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Mitchel Otieno Okumu ◽  
Francis Okumu Ochola ◽  
James Mucunu Mbaria ◽  
Laetitia Wakonyu Kanja ◽  
Daniel Waweru Gakuya ◽  
...  
Keyword(s):  
Liver Injury ◽  
Wistar Rats ◽  
Moringa Oleifera

scholarly journals Bioactive properties: enhancement of hepatoprotective, antioxidant and DNA damage protective effects of golden grey mullet protein hydrolysates against paracetamol toxicity

RSC Advances ◽  
2018 ◽  
Vol 8 (41) ◽  
pp. 23230-23240
Author(s):  
Intidhar Bkhairia ◽  
Sabah Dhibi ◽  
Rim Nasri ◽  
Abdelfettah Elfeki ◽  
Najla Hfaiyedh ◽  
...  
Keyword(s):  
Dna Damage ◽  
Liver Injury ◽  
Wistar Rats ◽  
Protein Hydrolysates ◽  
Protective Effects ◽  
Grey Mullet ◽  
Liza Aurata ◽  
Bioactive Properties ◽  
Paracetamol Toxicity ◽  
Dna Damage Protective

This study was undertaken to examine the hepatoprotective, antioxidant, and DNA damage protective effects of protein hydrolysates fromLiza aurata, against paracetamol overdose induced liver injury in Wistar rats.

scholarly journals EFFECT OF SINGLE INTAKE OF EXOGENOUS HEPATOCYTES GROWTH INDUCER ON THE INDICES OF NON-SPECIFIC RESISTANCE UNDER CONDITIONS OF POSTRESECTION LIVER INJURY

2016 ◽  
Vol 1 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Прокопьев ◽  
Maksim Prokopev ◽  
Коваль ◽  
Elena Koval ◽  
Курганский ◽  
...  
Keyword(s):  
Immune Response ◽  
Liver Resection ◽  
Liver Injury ◽  
Inflammatory Response ◽  
Postoperative Period ◽  
Wistar Rats ◽  
Specific Resistance ◽  
White Male ◽  
Early Postoperative Period ◽  
Male Wistar Rats

HGF is one of the factors taking part in regeneration and recovery of liver after injury. The article is dedicated to the study of influence of single HGF intake on the indices of non-specific immune response in rats after 70% liver resection in the early postoperative period. Research was conducted on 42 six-months white male Wistar rats of 250–300 g. It was revealed that level of segmentonuclear neutrophils and lymphocytes in the group with HGF intake stand at normal level on the 2nd day and normalizes to the 11th day that testifies to the decrease of inflammatory response. Increased level of leukocytes and monocytes is registered in the group with HGF intake. Also integrity of non-specific resistance in the early postoperative period on the 2nd day is registered. Suppression of phagocytosis indices with preservation of functional activity of phagocytes was registered to the 11th day.

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