scholarly journals Seasonal variation of macrolide resistance gene abundances in the South Fork Iowa River Watershed

2018 ◽  
Vol 610-611 ◽  
pp. 1173-1179 ◽  
Author(s):  
Elizabeth Luby Rieke ◽  
Thomas B. Moorman ◽  
Elizabeth L. Douglass ◽  
Michelle L. Soupir
2001 ◽  
Vol 45 (1) ◽  
pp. 263-266 ◽  
Author(s):  
Kavindra V. Singh ◽  
Kumthorn Malathum ◽  
Barbara E. Murray

ABSTRACT The complete sequence (1,479 nucleotides) of msrC, part of which was recently reported by others using a different strain, was determined. This gene was found in 233 of 233 isolates ofEnterococcus faecium but in none of 265 other enterococci. Disruption of msrC was associated with a two- to eightfold decrease in MICs of erythromycin azithromycin, tylosin, and quinupristin, suggesting that it may explain in part the apparent greater intrinsic resistance to macrolides of isolates of E. faecium relative to many streptococci. This endogenous, species-specific gene of E. faecium is 53% identical tomsr(A), suggesting that it may be a remote progenitor of the acquired macrolide resistance gene found in some isolates of staphylococci.


2005 ◽  
Vol 49 (10) ◽  
pp. 4180-4184 ◽  
Author(s):  
M. Rantala ◽  
S. Huikko ◽  
P. Huovinen ◽  
J. Jalava

ABSTRACT The prevalence and mechanisms of macrolide resistance among 1,007 clinical pneumococcal isolates collected in Finland were investigated. Of these, 217 (21.5%) were resistant to erythromycin and 11% to clindamycin. Among the erythromycin-resistant isolates, mef(E) was present in 95 isolates (44%), mef(A) was present in 12 isolates (6%), and erm(B) was present in 90 isolates (41%). A double mechanism, mef(E) and erm(B), was detected in five isolates (2%). Ribosomal mutation was detected in 14 (6%) macrolide-resistant isolates in which no other determinant was found. Based on the telithromycin MICs, two groups of isolates were formed: 83.3% of the isolates belonged to a major group for which the telithromycin MIC range was ≤0.008 to 0.063 μg/ml, and 16.7% belonged to a minor group for which the telithromycin MIC range was 0.125 to 8 μg/ml. All except three isolates in the minor population carried a macrolide resistance gene.


2009 ◽  
Vol 138 (3) ◽  
pp. 506-521 ◽  
Author(s):  
Sarah G. McCarthy ◽  
Jeffrey J. Duda ◽  
John M. Emlen ◽  
Garth R. Hodgson ◽  
David A. Beauchamp

2020 ◽  
Vol 75 (3) ◽  
pp. 245-253
Author(s):  
T.B. Moorman ◽  
D.E. James ◽  
J. Van Horn ◽  
S.A. Porter ◽  
M.D. Tomer

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