scholarly journals O044: Prevalence of macrolide resistance gene (ermF) in a Greek population in periodontal health and disease

2018 ◽  
Vol 45 ◽  
pp. 21-21
Keyword(s):  
Resistance Gene ◽  
Macrolide Resistance ◽  
Greek Population ◽  
Periodontal Health ◽  
Health And Disease ◽  
Macrolide Resistance Gene

scholarly journals Disruption of an Enterococcus faecium Species-Specific Gene, a Homologue of Acquired Macrolide Resistance Genes of Staphylococci, Is Associated with an Increase in Macrolide Susceptibility

2001 ◽  
Vol 45 (1) ◽  
pp. 263-266 ◽  
Author(s):  
Kavindra V. Singh ◽  
Kumthorn Malathum ◽  
Barbara E. Murray
Keyword(s):  
Resistance Gene ◽  
Resistance Genes ◽  
Enterococcus Faecium ◽  
Complete Sequence ◽  
Macrolide Resistance ◽  
Specific Gene ◽  
Intrinsic Resistance ◽  
Macrolide Resistance Gene ◽  
Species Specific

ABSTRACT The complete sequence (1,479 nucleotides) of msrC, part of which was recently reported by others using a different strain, was determined. This gene was found in 233 of 233 isolates ofEnterococcus faecium but in none of 265 other enterococci. Disruption of msrC was associated with a two- to eightfold decrease in MICs of erythromycin azithromycin, tylosin, and quinupristin, suggesting that it may explain in part the apparent greater intrinsic resistance to macrolides of isolates of E. faecium relative to many streptococci. This endogenous, species-specific gene of E. faecium is 53% identical tomsr(A), suggesting that it may be a remote progenitor of the acquired macrolide resistance gene found in some isolates of staphylococci.

scholarly journals Prevalence and Molecular Genetics of Macrolide Resistance among Streptococcus pneumoniae Isolates Collected in Finland in 2002

2005 ◽  
Vol 49 (10) ◽  
pp. 4180-4184 ◽  
Author(s):  
M. Rantala ◽  
S. Huikko ◽  
P. Huovinen ◽  
J. Jalava
Keyword(s):  
Streptococcus Pneumoniae ◽  
Resistance Gene ◽  
Molecular Genetics ◽  
Macrolide Resistance ◽  
Major Group ◽  
Minor Population ◽  
Macrolide Resistance Gene ◽  
A Minor

ABSTRACT The prevalence and mechanisms of macrolide resistance among 1,007 clinical pneumococcal isolates collected in Finland were investigated. Of these, 217 (21.5%) were resistant to erythromycin and 11% to clindamycin. Among the erythromycin-resistant isolates, mef(E) was present in 95 isolates (44%), mef(A) was present in 12 isolates (6%), and erm(B) was present in 90 isolates (41%). A double mechanism, mef(E) and erm(B), was detected in five isolates (2%). Ribosomal mutation was detected in 14 (6%) macrolide-resistant isolates in which no other determinant was found. Based on the telithromycin MICs, two groups of isolates were formed: 83.3% of the isolates belonged to a major group for which the telithromycin MIC range was ≤0.008 to 0.063 μg/ml, and 16.7% belonged to a minor group for which the telithromycin MIC range was 0.125 to 8 μg/ml. All except three isolates in the minor population carried a macrolide resistance gene.

scholarly journals Seasonal variation of macrolide resistance gene abundances in the South Fork Iowa River Watershed

2018 ◽  
Vol 610-611 ◽  
pp. 1173-1179 ◽  
Author(s):  
Elizabeth Luby Rieke ◽  
Thomas B. Moorman ◽  
Elizabeth L. Douglass ◽  
Michelle L. Soupir
Keyword(s):  
Seasonal Variation ◽  
Resistance Gene ◽  
Macrolide Resistance ◽  
South Fork ◽  
The South ◽  
River Watershed ◽  
Macrolide Resistance Gene

scholarly journals Cigarette smoke exposure induces expression of the pneumococcal erm(B) macrolide resistance gene

2019 ◽  
Vol 17 (November) ◽  
Author(s):  
Kgashane Matapa ◽  
Therese Dix-Peek ◽  
Riana Cockeran ◽  
Ronald Anderson ◽  
Helen Steel ◽  
...  
Keyword(s):  
Resistance Gene ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Macrolide Resistance ◽  
Cigarette Smoke Exposure ◽  
Macrolide Resistance Gene

scholarly journals Gingival crevicular fluid level of soluble triggering recep-tor expressed on myeloid cells-1(strem-1) in periodontal health and disease: a case-control study

2017 ◽  
Vol 5 (2) ◽  
pp. 83
Author(s):  
Surabhi Gigras ◽  
Sudhir R Patil ◽  
Veena HR ◽  
Sneha Dani
Keyword(s):  
Chronic Periodontitis ◽  
Myeloid Cells ◽  
Cell Surface Receptor ◽  
Periodontal Health ◽  
Group Iii ◽  
Root Planing ◽  
Group I ◽  
Health And Disease ◽  
Group Ii ◽  
Crevicular Fluid

Background: The Triggering Receptor Expressed On Myeloid Cells-1(TREM-1) is a cell-surface receptor of the immunoglobulin superfamily and found to be involved in the amplification of the inflammatory response to various microbial infections, including periodontal diseases.Objectives: The present study was designed to examine gingivalcrevicular fluid(GCF) levels of soluble TREM-1 (sTREM-1) levels in periodontal health and disease as well as evaluate the effect of scaling and/or root planing on the same.Methods: Based on gingival index, probing pocket depth, clinical attachment level, and radiologic parameters (bone loss), 45 subjects were initially divided into three groups- Group, I (Periodontally healthy), Group II (Gingivitis) and Group III (Chronic Periodontitis).From each of the subjects, GCF sample was collected at baseline and scaling and/or root planing was instituted in group II and group III patients. GCF samples were subsequently collected at eight-week interval. Levels of sTREM-1 in collected GCF samples were estimated using enzyme-linked immunosorbent assay.Results: The lowest GCF levels of sTREM-1 were found in periodontal health (69.50±1.8pg/ml) followed by gingivitis (257.17±79pg/ml) and chronic periodontitis (3658.14±55pg/ml) in increasing order, suggesting that levels of sTREM-1 in crevicular fluid increased with the severity of periodontal disease. sTREM-1 levels decreased significantly from baseline to the end of 8 weeks following non-surgical periodontal therapy.Conclusion: Increased GCF levels of sTREM-1 from periodontal health to disease strengthen its association with periodontal status.

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