Plain radiography or magnetic resonance imaging (MRI): Which is better in assessing outcome in clinical trials of disease-modifying osteoarthritis drugs? Summary of a debate held at the World Congress of Osteoarthritis 2014

2015 ◽  
Vol 45 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Felix Eckstein ◽  
Marie-Pierre Hellio Le Graverand
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Trials ◽  
Magnetic Resonance ◽  
Plain Radiography ◽  
Resonance Imaging ◽  
World Congress ◽  
The World ◽  
Disease Modifying ◽  
Magnetic Resonance Imaging Mri

scholarly journals Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis

2013 ◽  
Vol 20 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Nabeela Nathoo ◽  
V Wee Yong ◽  
Jeff F Dunn
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Clinical Trials ◽  
Magnetic Resonance ◽  
Animal Models ◽  
Mr Imaging ◽  
Preclinical Studies ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Potential Therapeutics

Major advances are taking place in the development of therapeutics for multiple sclerosis (MS), with a move past traditional immunomodulatory/immunosuppressive therapies toward medications aimed at promoting remyelination or neuroprotection. With an increase in diversity of MS therapies comes the need to assess the effectiveness of such therapies. Magnetic resonance imaging (MRI) is one of the main tools used to evaluate the effectiveness of MS therapeutics in clinical trials. As all new therapeutics for MS are tested in animal models first, it is logical that MRI be incorporated into preclinical studies assessing therapeutics. Here, we review key papers showing how MR imaging has been combined with a range of animal models to evaluate potential therapeutics for MS. We also advise on how to maximize the potential for incorporating MRI into preclinical studies evaluating possible therapeutics for MS, which should improve the likelihood of discovering new medications for the condition.

Magnetic Resonance Imaging of Axial and Peripheral Disease in Psoriatic Arthritis: A Report From the 2020 GRAPPA Annual Meeting

2021 ◽  
pp. jrheum.201676
Author(s):  
Walter P. Maksymowych ◽  
Mikkel Østergaard
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Trials ◽  
Psoriatic Arthritis ◽  
Magnetic Resonance ◽  
Imaging Modality ◽  
Scoring Systems ◽  
Resonance Imaging ◽  
Structural Abnormalities ◽  
The Status ◽  
Magnetic Resonance Imaging Mri

Psoriatic arthritis (PsA) presents with diverse features of musculoskeletal inflammation that affect both axial and peripheral joints as well as entheses, tenosynovium, and bursae. Magnetic resonance imaging (MRI) is the imaging modality that is uniquely capable of identifying pathology in all these structures. The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) Magnetic Resonance Imaging Working Group has increasingly explored diverse MRI methodologies for the purposes of quantifying inflammatory and structural abnormalities in clinical trials and research. The 2020 GRAPPA virtual workshop presented an opportunity to review progress in the field, summarize the status of MRI scoring systems developed for PsA, and review representative patient cases.

scholarly journals Analysis of Congenital Postaxial Polydactyly of the Foot Using Magnetic Resonance Imagings

2019 ◽  
Vol 4 (4) ◽  
pp. 2473011419S0014
Author(s):  
Jun Young Choi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Metatarsal Head ◽  
Plain Radiography ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Postaxial Polydactyly ◽  
Magnetic Resonance Imaging Mri

Category: Midfoot/Forefoot Introduction/Purpose: We aimed to evaluate the magnetic resonance imaging (MRI) findings of congenital postaxial polydactyly of the foot. Methods: Three-hundred and forty-seven feet of 288 patients who underwent congenital postaxial polydactyly or polysyndactyly correction were divided into five subtypes according to the radiographic shapes of deformity origins (widened metatarsal head, bifid, fused duplicated, incompletely duplicated, or completely duplicated). MRIs were assessed to determine whether they unrevealed areas were fused or separated. MRI was also used to assess cases with radiographic phalangeal aplasia. Results: Huge variations were noted in MRIs. Fusion or separation at the base or head between original and extra digits were observed, and MRI effectively depicted phalangeal aplastic. Conclusion: MRI evaluations of congenital postaxial polydactyly of the foot are useful for determining the anatomical statuses which were not visualized by plain radiography.

Selecting Magnetic Resonance Imaging (MRI) Outcome Measures for Juvenile Idiopathic Arthritis (JIA) Clinical Trials: First Report of the MRI in JIA Special Interest Group

2013 ◽  
Vol 41 (2) ◽  
pp. 354-358 ◽  
Author(s):  
Robert Hemke ◽  
Andrea S. Doria ◽  
Nikolay Tzaribachev ◽  
Mario Maas ◽  
Désirée M.F.M van der Heijde ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance Imaging ◽  
Clinical Trials ◽  
Juvenile Idiopathic Arthritis ◽  
Magnetic Resonance ◽  
Childhood And Adolescence ◽  
Resonance Imaging ◽  
Scoring Method ◽  
Magnetic Resonance Imaging Mri ◽  
Clinical Research Trials

Recent advances in magnetic resonance imaging (MRI) techniques have substantially improved the evaluation of joint pathologies in juvenile idiopathic arthritis (JIA). Because of the current availability of highly effective antirheumatic therapies and the unique and useful features of MRI, there is a growing need for an accurate and reproducible MRI assessment scoring system for JIA, such as the rheumatoid arthritis MRI Scoring (RAMRIS) for patients with rheumatoid arthritis (RA). To effectively evaluate the efficacy of treatment in clinical research trials, we need to develop and validate scoring methods to accurately measure joint outcomes, standardize imaging protocols for data acquisition and interpretation, and create imaging atlases to differentiate physiologic and pathologic joint findings in childhood and adolescence. Such a standardized, validated, JIA-MRI scoring method could be used as an outcome measure in clinical trials.

MRI FOR PRE-DEMENTIA TRIALS

2015 ◽  
pp. 1-3
Author(s):  
G.B. Frisoni ◽  
M. Boccardi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Trials ◽  
Magnetic Resonance ◽  
Early Stage ◽  
Good Reproducibility ◽  
Resonance Imaging ◽  
Clinical Progression ◽  
Structural Magnetic Resonance Imaging ◽  
High Measurement ◽  
Magnetic Resonance Imaging Mri

Structural magnetic resonance imaging (MRI) provides valid markers of whole brain and regional areas of atrophy in Alzheimer’s disease (AD), which are sensitive to change and correlate with clinical progression. Recent efforts to develop standardized and harmonized protocols for MRI indicate high measurement stability and good reproducibility, supporting the use of these measures in clinical trials. Newer MRI measures of microstructural and connectivity changes are also showing promise as early stage biomarkers of neurodegeneration and potentially as measures of treatment effects. Further work is needed to validate these markers for use in clinical trials.

Radiologically isolated syndrome – incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review

2012 ◽  
Vol 19 (3) ◽  
pp. 271-280 ◽  
Author(s):  
Tobias Granberg ◽  
Juha Martola ◽  
Maria Kristoffersen-Wiberg ◽  
Peter Aspelin ◽  
Sten Fredrikson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Cervical Cord ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Disease Modifying Therapy ◽  
Radiologically Isolated Syndrome ◽  
Disease Modifying ◽  
Magnetic Resonance Imaging Mri

With increasing availability of magnetic resonance imaging (MRI), there is also an increase in incidental abnormal findings. MRI findings suggestive of multiple sclerosis in persons without typical multiple sclerosis symptoms and with normal neurological findings are defined as radiologically isolated syndrome (RIS). Half of the persons with RIS have their initial MRI because of headache, and some have a subclinical cognitive impairment similar to that seen in multiple sclerosis. Radiological measurements also show a similarity between RIS and multiple sclerosis. Approximately two-thirds of persons with RIS show radiological progression and one-third develop neurological symptoms during mean follow-up times of up to five years. Cervical cord lesions are important predictors of clinical conversion. Management has to be individualised, but initiation of disease modifying therapy is controversial and not recommended outside of clinical trials since its effects have not been studied in RIS. Future studies should try to establish the prevalence and long-term prognosis of RIS, its impact on quality of life, and define the role of disease modifying therapy in RIS.

NEUROVISUAL CHARACTERISTICS OF STRUCTURAL ALTERATIONS OF BRAIN AT CHILDREN CEREBRAL PARALUSIS AND EPILEPSY

2020 ◽  
Vol 1 (1) ◽  
pp. 42-46
Author(s):  
Mavlyuda Artikova ◽  
◽  
Nozima Nabiyeva
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Epileptic Focus ◽  
Resonance Imaging ◽  
Structural Alterations ◽  
The World ◽  
Cerebral Paralysis ◽  
Symptomatic Epilepsy ◽  
Magnetic Resonance Imaging Mri ◽  
Low Sensitivity

Cerebral paralysis is the leading cause and serious matter of children's neurological invalidity throughout the world. Nowadays the forms of children's cerebral paralysis (CCP), complicated by symptomatic epilepsy (SE)which intencifies the disease are often being registered. Frequency of SE occurence come to 18-80 percent. Magnetic resonance imaging (MRI) is the first method of the investigation of patients with CCP with SE or without it. The target of the research is the improvement of SE diagnostics at CCP on the basis ofMRI investigation. Our results have relatively displayed low sensitivity of programmes of standart certificate at exposure of structural alterations of brain specific to epilepsy. Organic changes of brain at children do not constantlypoint out epileptic focus; mainly they are the indicators of brain ill-being

Methodologic Considerations in Planning Clinical Trials of Cost-Effectiveness of Magnetic Resonance Imaging With a Commentary on Guyatt and Drummond

1985 ◽  
Vol 1 (3) ◽  
pp. 567-581 ◽  
Author(s):  
Milton C. Weinstein
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Trials ◽  
Cost Effectiveness ◽  
Magnetic Resonance ◽  
Critical Discussion ◽  
Resonance Imaging ◽  
Clinical Magnetic Resonance Imaging ◽  
Or Methodology ◽  
Magnetic Resonance Imaging Mri ◽  
The Cost

The purpose of this paper is to outline some of the key methodologic issues in designing clinical trials to assess the cost-effectiveness of clinical magnetic resonance imaging (MRI). Because the possible objectives of such trials are so diverse, and the appropriate methodologies correspondingly numerous, no attempt is made to identify a single objective or methodology as appropriate. Rather, this paper should be read as an “options paper,” in which alternative formulations of objectives, outcome measures, study design, and protocol instrumentation are reviewed, with critical discussion of their theoretical strengths and weaknesses, as well as their practical implementability.

scholarly journals Effect of Metallic Ureteric Stents on Magnetic Resonance Imaging: Implications for Malignant Ureteral Obstruction

2021 ◽  
Vol 2 (4) ◽  
pp. 256-258
Author(s):  
Mahima Tellambura ◽  
Isaac Thangasamy ◽  
Kwang Chin ◽  
Declan Murphy
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Trials ◽  
Magnetic Resonance ◽  
Ureteric Obstruction ◽  
Resonance Imaging ◽  
Ureteric Stents ◽  
Diagnostic Certainty ◽  
Malignant Ureteral Obstruction ◽  
Magnetic Resonance Imaging Mri

Metallic ureteric stents are increasingly used for the management of malignant ureteric obstruction, a commonly encountered complication in urological and other malignancies. However, there has been limited evaluation of complications associated with these stents, including those that might arise from the use of magnetic resonance imaging (MRI). While most devices are deemed nominally “MRI-safe,” their implication on the quality of imaging produced has not been evaluated in clinical trials, and in our practice, significant artefact has been encountered with some ureteric stents—specifically, the Teleflex Rüsch DD tumour stent—compromising image quality and diagnostic certainty.

Sign in / Sign up

Export Citation Format

Share Document