Broad Efficacy of Scavenging Free Radicals: Cordyceps sp.

Scavenging free radical potency of cordycepin is the major bioactive segment extricated from Cordyceps species. In some new years, Cordyceps has gotten growing thought inferable from its distinctive restorative/pharmacological tests. This assessment reviews continuous explores on the counter oxidant impacts and the associated analyses of Cordyceps species. The results from our review show that Cordyceps of the cordycepin applies protective effects against hostile to oxidant injury for certain, afflictions including constant obstructive pneumonic infection (COPD), hepatitis, asthma, cerebral paralysis, Parkinson’s illness (PD), coronary course sickness (CAD), Alzheimer illness, respiratory failure, malignancy infection, maturing, waterfalls, and mind brokenness. Cordyceps coordinates the NF-κB, RIP2/Caspase-1, Akt/GSK-3β/p70S6K, TGF-β/Smads, and Nrf2/HO-1 hailing pathways among others of cordycepin. A couple of assessments focusing in on Cordyceps auxiliaries were surveyed and found to down metabolic speed of Cordyceps and augmentation its bioavailability. In addition, cordycepin further developed opposition, prevented the duplication of viral RNA, and covered cytokine storms, therefore proposing its capacity to treat COVID-19 and other viral defilements. From the accumulated and assessed information, this article gives the speculative reason to the clinical usages of cordycepin and inspects the way for future assessments focusing in on expanding the restorative use of Cordyceps species. Cordycepin and its analogs show unfathomable potential as the accompanying new class of against oxidant specialists.

PHOTODYNAMIC THERAPY WITH METHYLENE BLUE IN CHILDREN WITH CEREBRAL PARALYSIS

Children with cerebral palsy suffer from dental diseases almost three times more often than healthy children. Risk factors that cause the development of dental diseases in children with CP include low rates of unstimulated salivation rate, acidity, increased saliva osmolarity and total protein concentration, which indicates a violation of hydration. The above factors contribute to the formation of acquired pellicles and biofilms due to increased bacterial agglutination. Ultimately, this contributes to the accelerated formation of plaque. There is a tendency to increase the concentration of hemoglobin and reduce the degree of oxygenation of oxyhemoglobin and, as a result, to increase the active forms of oxygen and nitrogen, which, in turn, have a toxic effect and lead to cell death. Photodynamic therapy (PDT) using photosensitizers (FS) improves blood filling and the degree of oxygenation in periodontal tissues, and also allows the elimination of bacterial biofilm. At the same time, opto-spectral diagnostics painlessly in the monitoring mode allows to identify and fix tissue areas with low hemoglobin oxygenation rates for precision photodynamic effects. PDT is a method used as a therapy for oral diseases of various origins, such as cancer, precancerous diseases, caries, periodontitis and gingivitis. Initially, methylene blue was the first dye used in medicine as an antiseptic, as well as the first tested and approved photosensitizer for antimicrobial photodynamic therapy. The use of photodynamic therapy with methylene blue as a photosensitizer can allow to deactivate inflammation and completely destroy bacteria in the biofilm, which will contribute to the functional normalization of gum tissue and restore oxygenation in the microcirculatory bed. The advantages of this method are antibacterial, anti-inflammatory and wound healing effects. The article presents the literature data on photodynamic therapy with the use of methylene blue in children, on the methodology and results of the use of this treatment technique in practice.

Criteria for assessing the level of physical fitness and physical state of football players with cerebral paralysis, taking into account their sports classes

Background and Study Aim. The article is devoted to finding ways to optimize the training of players with cerebral palsy (CP). It is determined that testing and elaboration of criteria for assessing the level of physical fitness of football players with cerebral palsy can be used as a mean of evaluation the sportsmanship of football players of this nosology in training and competitive activities. The purpose of the study is to determine the level of physical and functional preparedness of football players with cerebral paralysis and to develop criteria for their evaluation during the intensive training period, taking into account the functional classes of athletes. Material and Methods. 25 football players with cerebral palsy, candidates and members of the national team of Ukraine, three-time Paralympic champions, multiple world and European champions took part in the study voluntarily. Athletes of the selected group have 5-8 classes of the adapted classification of the International Association of Cerebral Palsy (CP-ISRA) for CP-Football. Biochemical parameters were studied before and after training work of different focus. The value of maximum oxygen consumption (MOC) was determined by means of bicycle ergometric testing. The physical state and level of physical fitness of football players were monitored during the study. The research was conducted on the basis of the research laboratory of Prydniprovsk State Academy of Physical Culture and Sport and on the basis of the Municipal Institution "Dnipropetrovsk Medical and Physical Dispensary" of the Dnipropetrovsk Regional Council. Results. It was found that athletes with cerebral paralysis are able to adequately tolerate heavy physical loads. Football players with disabilities had biochemical parameters of blood sampling and registration of recovery processes of the cardiovascular system after training activities of different focus within the permissible norm for both healthy athletes. Obtaining such data became the basis for the intensification of training process, which promoted the development of motor skills of football players. Conclusions. Obtained data were the basis for creation the criteria for assessing the level of physical fitness of football players depending on their sports classes. In future, this will allow coaches to determine the effectiveness of the training period, obtain information about the condition of players in training, in the recovery process. On this basis it will help to individualize the workload of players and adjust the training process. The analysis of a direction of preparation and decision-making about educational process correction for football players with disabilities can be realized according to the received data in various structural formations of an annual macrocycle.

The ethiology of idiocy is compared with that of children with cerebral palsy. - Dr. W. Koenig. (Allg. Zeitschr. Für psych. 1904. C. 61)

The author, based on the collected and statistically developed material, comes to the conclusion in the existence of three undoubted ethiological moments for the occurrence of cerebral paralysis and idiocy.

DEVELOPMENT OF COORDINATION ABILITIES LEARNING OF THE YOUNG SCHOOL AGE WITH CHILDREN CEREBRAL PARALYSIS ON ADAPTIVE PHYSICAL CULTURE

The main task that is solved in the process of physical education of children and adolescents is to ensure the optimal accessible development of physical qualities. The increasing requirements for the physical education of students actualize the search for new ways and methodological approaches that would ensure an increase in their physical activity. In the process of educational activity, it is necessary to achieve the development of physical qualities in students, which formed, maintained an optimal level of health, supported physical development, and physical fitness. The article presents the reasonable and organized structure of the process of physical education of primary school children with the cerebral palsy diagnosis on the adaptive physical education lessons, taking into account the proposed methods of coordinational abilities development with this category of pupils.

Grub in the mouth: an unusual case with review of literature

Oral myiasis is a rare disease, identified primarily in non-industrialised nations. It is caused fundamentally by the attack of larvae from Dipteran flies on the human tissues. Predisposing factors for oral myiasis are extraction wounds, destitute oral cleanliness, meagreness, mouth breathing amid rest, suppurative injuries, necrotic tissues, diabetes and perivascular infections primarily within the elderly, extreme halitosis, alcohol addiction, cerebral paralysis and components that favour prolonged mouth opening. Myiasis may have predilection to patients with mental challenges, cerebral palsy and hemiplegia due to unfortunate physical agility. The present case reports an oral myiasis in a 25-year-old woman who was mentally challenged. This condition was treated by topical application of turpentine oil with manual expulsion of hatchlings, taken after by surgical debridement and wide range antimicrobials.