This paper presents a novel architecture for a bio-detection system to reuse magnetoresistive sensors and improve its repeatability. The architecture is composed of two fixed magnetoresistive sensors, a movable biochip, a microfluidic device and two current straps. On the action of a magnetic field gradient generated by current strap, functional magnetic particles pass along the channel. Some particles are bound by a special reaction to the biochip surface, and magnetoresistive sensors on the two ends measure the number of particles of original state and subsequencial state. The signal difference of two magnetoresistive sensors reflect the number of the depletion magnetic particles captured by the biochip.
Integrated droplet microfluidic device for magnetic particles handling: Application to DNA size selection in NGS libraries preparation
