scholarly journals RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis

2022 ◽  
Author(s):  
Chanyi Lu ◽  
Xiaoli Lin ◽  
Jumpei Yamashita ◽  
Ranhui Xi ◽  
Minliang Zhou ◽  
...  
Keyword(s):  
Tissue Homeostasis ◽  
Epithelial Tissue

scholarly journals p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells

2007 ◽  
Vol 177 (5) ◽  
pp. 795-807 ◽  
Author(s):  
Stefan Wöll ◽  
Reinhard Windoffer ◽  
Rudolf E. Leube
Keyword(s):  
P38 Mapk ◽  
Intermediate Filament ◽  
Cultured Cells ◽  
Physiological Stress ◽  
Tissue Homeostasis ◽  
Epithelial Tissue ◽  
Down Regulation ◽  
Granule Formation ◽  
Keratin Filament ◽  
Filament Network

Plasticity of the resilient keratin intermediate filament cytoskeleton is an important prerequisite for epithelial tissue homeostasis. Here, the contribution of stress-activated p38 MAPK to keratin network organization was examined in cultured cells. It was observed that phosphorylated p38 colocalized with keratin granules that were rapidly formed in response to orthovanadate. The same p38p recruitment was noted during mitosis, in various stress situations and in cells producing mutant keratins. In all these situations keratin 8 became phosphorylated on S73, a well-known p38 target site. To demonstrate that p38-dependent keratin phosphorylation determines keratin organization, p38 activity was pharmacologically and genetically modulated: up-regulation induced keratin granule formation, whereas down-regulation prevented keratin filament network disassembly. Furthermore, transient p38 inhibition also inhibited keratin filament precursor formation and mutant keratin granule dissolution. Collectively, the rapid and reversible effects of p38 activity on keratin phosphorylation and organization in diverse physiological, stress, and pathological situations identify p38-dependent signalling as a major intermediate filament–regulating pathway.

scholarly journals Chlamydia trachomatis Disturbs Epithelial Tissue Homeostasis in Fallopian Tubes via Paracrine Wnt Signaling

2012 ◽  
Vol 180 (1) ◽  
pp. 186-198 ◽  
Author(s):  
Mirjana Kessler ◽  
Julia Zielecki ◽  
Oliver Thieck ◽  
Hans-Joachim Mollenkopf ◽  
Christina Fotopoulou ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Wnt Signaling ◽  
Tissue Homeostasis ◽  
Epithelial Tissue ◽  
Fallopian Tubes

scholarly journals Tuning of Protein Kinase Circuitry by p38α Is Vital for Epithelial Tissue Homeostasis

2013 ◽  
Vol 288 (33) ◽  
pp. 23788-23797 ◽  
Author(s):  
Celia Caballero-Franco ◽  
Min-Kyung Choo ◽  
Yasuyo Sano ◽  
Patcharee Ritprajak ◽  
Hiroaki Sakurai ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tissue Homeostasis ◽  
Epithelial Tissue

scholarly journals Flexibility sustains epithelial tissue homeostasis

2019 ◽  
Vol 60 ◽  
pp. 84-91 ◽  
Author(s):  
Karen Tai ◽  
Katie Cockburn ◽  
Valentina Greco
Keyword(s):  
Tissue Homeostasis ◽  
Epithelial Tissue

Mechanics of Epithelial Tissue Homeostasis and Morphogenesis

Science ◽  
2013 ◽  
Vol 340 (6137) ◽  
pp. 1185-1189 ◽  
Author(s):  
Charlène Guillot ◽  
Thomas Lecuit
Keyword(s):  
Epithelial Cells ◽  
Tissue Homeostasis ◽  
Pivotal Role ◽  
Epithelial Tissue ◽  
Fluid Behavior ◽  
Functional Tissue ◽  
Vital Functions ◽  
Mechanical Basis ◽  
Tight Association

Epithelia are robust tissues that support the structure of embryos and organs and serve as effective barriers against pathogens. Epithelia also chemically separate different physiological environments. These vital functions require tight association between cells through the assembly of junctions that mechanically stabilize the tissue. Remarkably, epithelia are also dynamic and can display a fluid behavior. Cells continuously die or divide, thereby allowing functional tissue homeostasis. Epithelial cells can change shape or intercalate as tissues deform during morphogenesis. We review the mechanical basis of tissue robustness and fluidity, with an emphasis on the pivotal role of junction dynamics. Tissue fluidity emerges from local active stresses acting at cell interfaces and allows the maintenance of epithelial organization during morphogenesis and tissue renewal.

scholarly journals Mechanical Regulation of Epithelial Tissue Homeostasis

2021 ◽  
Vol 11 (3) ◽  
Author(s):  
Sara Kaliman ◽  
Maxime Hubert ◽  
Carina Wollnik ◽  
Lovro Nuić ◽  
Damir Vurnek ◽  
...  
Keyword(s):  
Tissue Homeostasis ◽  
Epithelial Tissue ◽  
Mechanical Regulation
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