scholarly journals Corrigendum to “Fully supercritical CO2 preparation of a nanostructured MOF composite with application in cutaneous drug delivery” [J. Supercrit. Fluids 178 (2021) 105379]

2022 ◽  
Vol 179 ◽  
pp. 105416
Author(s):  
Márta Kubovics ◽  
Sara Rojas ◽  
Ana M. López-Periago ◽  
Julio Fraile ◽  
Patricia Horcajada ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2

scholarly journals Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1347
Author(s):  
Arbanah Muhammad ◽  
Dabin Lee ◽  
Yonghun Shin ◽  
Juhyun Park
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2 ◽  
Wound Dressing ◽  
Freeze Drying ◽  
Recent Progress ◽  
Present Review ◽  
Porous Structures ◽  
Air Filtration ◽  
Future Outlook ◽  
Synthetic Process

Porous polysaccharides have recently attracted attention due to their porosity, abundance, and excellent properties such as sustainability and biocompatibility, thereby resulting in their numerous applications. Recent years have seen a rise in the number of studies on the utilization of polysaccharides such as cellulose, chitosan, chitin, and starch as aerogels due to their unique performance for the fabrication of porous structures. The present review explores recent progress in porous polysaccharides, particularly cellulose and chitosan, including their synthesis, application, and future outlook. Since the synthetic process is an important aspect of aerogel formation, particularly during the drying step, the process is reviewed in some detail, and a comparison is drawn between the supercritical CO2 and freeze drying processes in order to understand the aerogel formation of porous polysaccharides. Finally, the current applications of polysaccharide aerogels in drug delivery, wastewater, wound dressing, and air filtration are explored, and the limitations and outlook of the porous aerogels are discussed with respect to their future commercialization.

Evaluation of drug delivery characteristics of microspheres of PMMA–PCL–cholesterol obtained by supercritical-CO2 impregnation and by dissolution–evaporation techniques

2004 ◽  
Vol 99 (2) ◽  
pp. 231-240 ◽  
Author(s):  
Carlos Elvira ◽  
Alejandra Fanovich ◽  
Mar Fernández ◽  
Julio Fraile ◽  
Julio San Román ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2

scholarly journals Supercritical CO2 Assisted Impregnation of Ibuprofen on Medium-Chain-Length Polyhydroxyalkanoates (mcl-PHA)

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4772
Author(s):  
Liane Meneses ◽  
Rita Craveiro ◽  
Ana Rita Jesus ◽  
Maria A. M. Reis ◽  
Filomena Freitas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2 ◽  
Drug Delivery Systems ◽  
Release Profile ◽  
Pseudomonas Chlororaphis ◽  
Type Ii ◽  
Topical Drug Delivery ◽  
Adhesive Properties ◽  
Medium Chain Length ◽  
Impregnation Time

In this work, we propose the utilization of scCO2 to impregnate ibuprofen into the mcl-PHA matrix produced by Pseudomonas chlororaphis subs. aurantiaca (DSM 19603). The biopolymer has adhesive properties, is biocompatible and has a melting temperature of 45 °C. Several conditions, namely, pressure (15 and 20 MPa) and impregnation time (30 min, 1 h and 3 h) were tested. The highest ibuprofen content (90.8 ± 6.5 mg of ibuprofen/gPHA) was obtained at 20 MPa and 40 °C, for 1 h, with an impregnation rate of 89 mg/(g·h). The processed mcl-PHA samples suffered a plasticization, as shown by the decrease of 6.5 °C in the Tg, at 20 MPa. The polymer’s crystallinity was also affected concomitantly with the matrices’ ibuprofen content. For all the impregnation conditions tested the release of ibuprofen from the biopolymer followed a type II release profile. This study has demonstrated that the mcl-PHA produced by P. chlororaphis has a great potential for the development of novel topical drug delivery systems.

Supercritical CO2 processing of polymers for the production of materials with applications in tissue engineering and drug delivery

2008 ◽  
Vol 43 (6) ◽  
pp. 1939-1947 ◽  
Author(s):  
Ana M. López-Periago ◽  
Arlette Vega ◽  
Pascale Subra ◽  
Anna Argemí ◽  
Javier Saurina ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Supercritical Co2

Supercritical CO2 generating chitosan devices with controlled morphology. Potential application for drug delivery and mesenchymal stem cell culture

2009 ◽  
Vol 48 (3) ◽  
pp. 269-277 ◽  
Author(s):  
Márcio Temtem ◽  
Lígia M.C. Silva ◽  
Pedro Z. Andrade ◽  
Francisco dos Santos ◽  
Cláudia Lobato da Silva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Culture ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Potential Application ◽  
Supercritical Co2 ◽  
Mesenchymal Stem Cell Culture ◽  
Stem Cell Culture ◽  
Controlled Morphology

Applications of supercritical CO2 in the fabrication of polymer systems for drug delivery and tissue engineering

2008 ◽  
Vol 60 (3) ◽  
pp. 373-387 ◽  
Author(s):  
Owen R. Davies ◽  
Andrew L. Lewis ◽  
Martin J. Whitaker ◽  
Hongyun Tai ◽  
Kevin M. Shakesheff ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Supercritical Co2 ◽  
Polymer Systems

Insulin-loaded poly-l-lactide porous microspheres prepared in supercritical CO2 for pulmonary drug delivery

2015 ◽  
Vol 101 ◽  
pp. 117-123 ◽  
Author(s):  
Ai-Zheng Chen ◽  
Na Tang ◽  
Shi-Bin Wang ◽  
Yong-Qiang Kang ◽  
Hu-Fan Song
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2 ◽  
Pulmonary Drug Delivery ◽  
Porous Microspheres

Fully supercritical CO2 preparation of a nanostructured MOF composite with application in cutaneous drug delivery

2021 ◽  
pp. 105379
Author(s):  
Márta Kubovics ◽  
Sara Rojas ◽  
Ana M. López ◽  
Julio Fraile ◽  
Patricia Horcajada ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2

Preparation of drug delivery biodegradable PLGA nanocomposites and foams by supercritical CO2 expanded ring opening polymerization and by rapid expansion from CHCIF2 supercritical solutions

2004 ◽  
Vol 845 ◽  
Author(s):  
Alexandru D. Asandei ◽  
Can Erkey ◽  
Diane J. Burgess ◽  
Carl Saquing ◽  
Gobinda Saha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Low Temperatures ◽  
Ring Opening ◽  
Supercritical Co2 ◽  
Glycolic Acid ◽  
Ring Opening Polymerization ◽  
Rapid Expansion ◽  
Poly Lactic Acid ◽  
Fluorinated Surfactants ◽  
Large Particles

ABSTRACTThe synthesis of poly(lactic-co-glycolic acid) (PLGA) by the ring opening copolymerization of D, L-lactide and glycolide was performed at 110 °C to 130 °C using Sn(Oct)2 as catalyst, 1, 10-decanediol as initiator in a supercritical sc-CO2 expanded medium at pressures of up to 3, 500 psi. Due to the limited monomer solubility in sc-CO2 at low temperatures (70 °C), only Mn = 2, 500 is typically obtained. However, molecular weight increases with both temperature and sc-CO2 pressure. Thus, Mn = 13, 000 (PDI = 1.28) was obtained at 110 °C - 130 °C even in the absence of fluorinated surfactants. Biodegradable drug delivery nanocomposites based on dexamethasone and poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) were prepared by the rapid expansion of the corresponding supercritical CHClF2 solutions (110 °C, 200-300 bar) in air (RESS) and in toluene (RESOLV). The RESS process leads to a broad particle size distribution (100-500 nm) while the RESOLV generates a narrower distribution centered around 100 nm and is accompanied by the formation of a few large particles, most likely due to aggregation.

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