scholarly journals Supercritical CO2 Assisted Impregnation of Ibuprofen on Medium-Chain-Length Polyhydroxyalkanoates (mcl-PHA)

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4772
Author(s):  
Liane Meneses ◽  
Rita Craveiro ◽  
Ana Rita Jesus ◽  
Maria A. M. Reis ◽  
Filomena Freitas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2 ◽  
Drug Delivery Systems ◽  
Release Profile ◽  
Pseudomonas Chlororaphis ◽  
Type Ii ◽  
Topical Drug Delivery ◽  
Adhesive Properties ◽  
Medium Chain Length ◽  
Impregnation Time

In this work, we propose the utilization of scCO2 to impregnate ibuprofen into the mcl-PHA matrix produced by Pseudomonas chlororaphis subs. aurantiaca (DSM 19603). The biopolymer has adhesive properties, is biocompatible and has a melting temperature of 45 °C. Several conditions, namely, pressure (15 and 20 MPa) and impregnation time (30 min, 1 h and 3 h) were tested. The highest ibuprofen content (90.8 ± 6.5 mg of ibuprofen/gPHA) was obtained at 20 MPa and 40 °C, for 1 h, with an impregnation rate of 89 mg/(g·h). The processed mcl-PHA samples suffered a plasticization, as shown by the decrease of 6.5 °C in the Tg, at 20 MPa. The polymer’s crystallinity was also affected concomitantly with the matrices’ ibuprofen content. For all the impregnation conditions tested the release of ibuprofen from the biopolymer followed a type II release profile. This study has demonstrated that the mcl-PHA produced by P. chlororaphis has a great potential for the development of novel topical drug delivery systems.

A Non-Invasive, Low-Cost Study Design to Determine the Release Profile of Colon Drug Delivery Systems: A Feasibility Study

2012 ◽  
Vol 29 (8) ◽  
pp. 2070-2078 ◽  
Author(s):  
Marina J. M. Maurer ◽  
Reinout C. A. Schellekens ◽  
Klaus D. Wutzke ◽  
Gerard Dijkstra ◽  
Herman J. Woerdenbag ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Feasibility Study ◽  
Study Design ◽  
Drug Delivery Systems ◽  
Low Cost ◽  
Delivery Systems ◽  
Release Profile ◽  
Cost Study ◽  
Non Invasive ◽  
Colon Drug Delivery

scholarly journals Nanotechnology-Based Topical Drug Delivery Systems for Management of Dandruff and Seborrheic Dermatitis: An overview

2020 ◽  
Vol 29 (1) ◽  
pp. 12-32
Author(s):  
Lena M. Thomas ◽  
Abeer H. Khasraghi
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Seborrheic Dermatitis ◽  
Delivery Systems ◽  
Drug Formulation ◽  
Topical Drug Delivery ◽  
Skin Disorders ◽  
Common Skin

Dandruff and seborrheic dermatitis (SD) are common skin disorders affecting the scalp and extending to other body sites in the case of SD. They are associated with pruritus and scaling, causing an esthetical disturbance in the population affected.   Treatment of such conditions involves using a variety of drugs for long terms, thus optimizing drug formulation is essential to improve therapeutic efficacy and patient compliance. Conventional topical formulations like shampoos and creams have been widely used but their use is associated with disadvantages. To overcome such effects, novel topical nanotechnology-based formulations are currently under investigation. In the following article, we highlight recently published formulation approaches used to improve topical dandruff/SD therapy

scholarly journals Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharmaceutical Ingredients (APIs)

2021 ◽  
Vol 22 (18) ◽  
pp. 9743
Author(s):  
Eliana B. Souto ◽  
Ana S. Macedo ◽  
João Dias-Ferreira ◽  
Amanda Cano ◽  
Aleksandra Zielińska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
First Generation ◽  
Delivery Systems ◽  
Topical Drug Delivery ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Administration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phospholipids, which are key components of cell membranes, making liposomes well tolerated and devoid of toxicity. As their lipid compositions are similar to those of the skin, liposomes are used as topical, dermal, and transdermal delivery systems. However, permeation of the first generation of liposomes through the skin posed some limitations; thus, a second generation of liposomes has emerged, overcoming permeability problems. Various mechanisms of permeation/penetration of elastic/ultra-deformable liposomes into the skin have been proposed; however, debate continues on their extent/mechanisms of permeation/penetration. In vivo bioavailability of an API administered in the form of ultra-deformable liposomes is similar to the bioavailability achieved when the same API is administered in the form of a solution by subcutaneous or epi-cutaneous injection, which demonstrates their applicability in transdermal drug delivery.

Emulgel: A Review

2021 ◽  
pp. 263-268
Author(s):  
Sahil Hasan ◽  
Saloni Bhandari ◽  
Anshu Sharma ◽  
Poonam Garg
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Control Release ◽  
Delivery Systems ◽  
Antifungal Drugs ◽  
Therapeutic Drug ◽  
Topical Drug Delivery ◽  
Drug Molecules ◽  
Control Release System ◽  
Conventional Systems

Emulgel systems are currently attention to the pharmaceutical sectors because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules and higher stability compared to the other dosage form like cream, lotion, gel, etc. Emulsions are either available in an oil in water or water in oil type. These are prepared by the incorporation of the emulsion into the gel with constant stirring at a moderate speed. Incorporation of emulsion into a gel makes it a dual control release system, thereby, increasing its stability. It has better drug release if we compare to other topical drug delivery system. It is non greasy because of the presence of gel phase which enhances patient compliance. Gels has a major limitation for the delivery of hydrophobic drugs, so to overcome this limitation an emulsion based approach is being used so that even a hydrophobic therapeutic drug can enjoy the unique properties of gels. In recent years, these have also been a great interest in the use of novel polymers. These emulgels are having major advantages on vesicular drug delivery systems as well as on conventional systems in various aspects. Various permeation enhancers can enhance the effect; due to this emulgels can be used as better topical drug delivery systems over current drug delivery systems. The emulsion can be use for analgesics and antifungal drugs.

Rheological, Mechanical and Adhesive Properties of Surfactant-Containing Systems Designed as a Potential Platform for Topical Drug Delivery

2012 ◽  
Vol 8 (2) ◽  
pp. 280-289 ◽  
Author(s):  
Flávia Chiva Carvalho ◽  
Hilris Rocha e Silva ◽  
Gabriela Marielli da Luz ◽  
Mariana da Silva Barbi ◽  
Daniele Silveira Landgraf ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Topical Drug Delivery ◽  
Adhesive Properties
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